Rap guanine nucleotide exchange factor (GEF) 3

Synonym

RAP guanine-nucleotide-exchange factor (GEF) 3, MGC21410, Epac 1, EPAC, Rap guanine nucleotide exchange factor 3, Rap guanine nucleotide exchange factor (GEF) 3, RAPGEF3, EPAC1, bcm910, CGEF1, Exchange factor directly activated by cAMP 1, cAMP-GEFI, CAMP-GEFI

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:79.40

cerebellum:75.60

brain stem:-

corpus callosum/glia:58.30

pineal gland:-

peripheral nerve:122.70

spine:-

retina:-

eye:11.80

artery/aorta:89.90

vein:466.50

lymphnode:-

peripheral blood:18.20

spleen:75.60

thymus:25.80

bone marrow:-

adipose:40.30

bone:25.60

skin:14.40

GeneChip

cerebrum:6.37

cerebellum:5.34

brain stem:6.17

corpus callosum/glia:7.18

pineal gland:-

peripheral nerve:5.62

spine:6.18

retina:-

eye:-

artery/aorta:6.84

vein:5.94

lymphnode:5.77

peripheral blood:-

spleen:6.41

thymus:5.23

bone marrow:5.22

adipose:6.82

bone:-

skin:6.30

CAGE

cerebrum:3.41

cerebellum:-

brain stem:3.65

corpus callosum/glia:4.22

pineal gland:3.53

peripheral nerve:-

spine:3.38

retina:-

eye:-

artery/aorta:2.95

vein:2.69

lymphnode:1.89

peripheral blood:-

spleen:2.21

thymus:0.57

bone marrow:-

adipose:3.85

bone:-

skin:-

RNA-seq

cerebrum:1.27

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.19

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:82

placenta:61.90

prostate:22.50

ovary:37.30

testis:17.30

heart:38.30

muscle:-

esophagus:-

stomach:-

intestine:32.40

colon:-

liver/hepato:-

lung:34.20

bladder:-

kidney:31.20

pituitary:-

thyroid/parathyroid:327.50

adrenal gland:-

pancreas:8.90

breast:27.90

salivary:-

GeneChip

uterus:5.93

placenta:5.60

prostate:5.72

ovary:6.36

testis:5.13

heart:6.20

muscle:5.81

esophagus:6.16

stomach:5.77

intestine:5.51

colon:5.58

liver/hepato:5.42

lung:6.26

bladder:-

kidney:7.01

pituitary:5.43

thyroid/parathyroid:7.47

adrenal gland:5.64

pancreas:5.62

breast:6.22

salivary:6.27

CAGE

uterus:3.16

placenta:2.50

prostate:2.64

ovary:2.62

testis:1.61

heart:2.60

muscle:2.03

esophagus:2.51

stomach:-

intestine:1.53

colon:1.89

liver/hepato:1.07

lung:2.66

bladder:2.02

kidney:3.61

pituitary:1.81

thyroid/parathyroid:3.07

adrenal gland:-

pancreas:1.21

breast:3.81

salivary:3.13

RNA-seq

uterus:-

placenta:-

prostate:1.36

ovary:1.52

testis:0.98

heart:0.86

muscle:0.37

esophagus:-

stomach:-

intestine:-

colon:0.72

liver/hepato:0.00

lung:1.14

bladder:-

kidney:2.84

pituitary:-

thyroid/parathyroid:1.84

adrenal gland:1.49

pancreas:-

breast:2.01

salivary:-

IDs

Refseq ID	NM_006105
Gene ID	10411
Unigene ID	Hs.8578
Probe set ID	210051_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000079337
GTEx ID	ENSG00000079337

Orthologous Gene

Mouse[3]	NM_001177810, NM_001177811, NM_144850
Rat [0]

Chromosomal Region

12q13.11 [48,128,455 - 48,164,823]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000595	Cyclic nucleotide-binding
IPR018490	Cyclic nucleotide-binding-like
IPR000591	DEP domain
IPR014710	RmlC-like jelly roll fold
IPR011991	Winged helix repressor DNA-binding

Gene Ontology (GO ID)

Biological Process

GO:0001525	angiogenesis
GO:0007596	blood coagulation
GO:0019933	cAMP-mediated signaling
GO:0008283	cell proliferation
GO:0006112	energy reserve metabolic process
GO:0030168	platelet activation
GO:0045766	positive regulation of angiogenesis
GO:0030822	positive regulation of cAMP catabolic process
GO:0050796	regulation of insulin secretion
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction

Cellular Component

GO:0005952	cAMP-dependent protein kinase complex
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0005886	plasma membrane

Molecular Function

GO:0030552	cAMP binding
GO:0008603	cAMP-dependent protein kinase regulator activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Rap guanine nucleotide exchange factor (GEF) 3

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function