forkhead box E3

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Synonym

FKHL12, Forkhead-related transcription factor 8, forkhead box E3, FOXE3, Forkhead box protein E3, ASMD, FREAC8, FREAC-8, Forkhead-related protein FKHL12

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:23.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.76 cerebellum:4.77 brain stem:4.70 corpus callosum/glia:4.74 pineal gland:- peripheral nerve:4.82 spine:4.81 retina:- eye:- artery/aorta:4.91 vein:4.90 lymphnode:4.77 peripheral blood:- spleen:4.64 thymus:4.66 bone marrow:4.84 adipose:4.77 bone:- skin:4.83
CAGE cerebrum:0.01 cerebellum:- brain stem:0 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0.33 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.06 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:8.70 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.66 placenta:4.76 prostate:4.64 ovary:4.65 testis:4.73 heart:4.69 muscle:4.70 esophagus:4.77 stomach:4.69 intestine:4.78 colon:4.68 liver/hepato:4.81 lung:4.92 bladder:- kidney:4.72 pituitary:4.82 thyroid/parathyroid:4.78 adrenal gland:4.72 pancreas:4.81 breast:4.68 salivary:4.66
CAGE uterus:0.04 placenta:0 prostate:0 ovary:0 testis:0.16 heart:0 muscle:0 esophagus:0 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.02 ovary:0 testis:0.41 heart:0 muscle:0.09 esophagus:- stomach:- intestine:- colon:0.06     liver/hepato:0.01        lung:0    bladder:- kidney:0.16 pituitary:- thyroid/parathyroid:0 adrenal gland:0.04 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_012186
Gene ID 2301
Unigene ID Hs.112968
Probe set ID 220621_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000186790
GTEx ID ENSG00000186790

Orthologous Gene

Mouse[1]  NM_015758
Rat[1]  NM_015758

Chromosomal Region

1p33  [47,881,744  -  47,883,723]

Gene Family (Interpro ID)

IPR001766  Transcription factor, fork head
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

8825632
10652278
11159941
16710414
16826526
19708017
20140963
20361012
20630806
20664696
20806047
21150893
22204637
22527307
24019743

Gene Ontology  (GO ID)

Biological Process

GO:0048846  axon extension involved in axon guidance
GO:0016477  cell migration
GO:0048562  embryonic organ morphogenesis
GO:0048484  enteric nervous system development
GO:0031069  hair follicle morphogenesis
GO:0060022  hard palate development
GO:0048937  lateral line nerve glial cell development
GO:0002089  lens morphogenesis in camera-type eye
GO:0007275  multicellular organismal development
GO:0007389  pattern specification process
GO:0007422  peripheral nervous system development
GO:0050679  positive regulation of epithelial cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0051090  regulation of transcription factor activity
GO:0006355  regulation of transcription, DNA-dependent
GO:0060023  soft palate development
GO:0048485  sympathetic nervous system development
GO:0030878  thyroid gland development
GO:0006590  thyroid hormone generation
GO:0006366  transcription from RNA polymerase II promoter

Cellular Component

GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0008301  DNA bending activity
GO:0003690  double-stranded DNA binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding