guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1

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Synonym

Transducin alpha-1 chain, GNAT1, GBT1, GNATR

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:711.80 eye:623 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.38 cerebellum:4.51 brain stem:4.47 corpus callosum/glia:4.30 pineal gland:- peripheral nerve:4.06 spine:4.10 retina:- eye:- artery/aorta:4.07 vein:4.48 lymphnode:4.18 peripheral blood:- spleen:4.01 thymus:3.97 bone marrow:4.21 adipose:4.25 bone:- skin:4.17
CAGE cerebrum:0.01 cerebellum:- brain stem:0 corpus callosum/glia:0 pineal gland:2.76 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.22 placenta:3.68 prostate:3.90 ovary:4.33 testis:4.08 heart:4.58 muscle:4.62 esophagus:4.40 stomach:4.15 intestine:4.33 colon:4.37 liver/hepato:4.35 lung:4.27 bladder:- kidney:4.38 pituitary:4.26 thyroid/parathyroid:4.04 adrenal gland:4.34 pancreas:4.77 breast:4.17 salivary:4.51
CAGE uterus:0 placenta:0 prostate:0 ovary:0 testis:0.10 heart:0 muscle:0 esophagus:0 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:0 thyroid/parathyroid:0.06 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0 ovary:0 testis:0.30 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0.03        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_144499
Gene ID 2779
Unigene ID Hs.517978
Probe set ID 207514_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000114349
GTEx ID ENSG00000114349

Orthologous Gene

Mouse[1]  NM_008140
Rat[1]  NM_001108780

Chromosomal Region

3p21.31  [50,229,045  -  50,233,949]

Gene Family (Interpro ID)

IPR001408  G-protein alpha subunit, group I
IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit

Link to Pubmed  (Pubmed ID)

1302014
1614872
1898771
2534964
2748346
2902634
7822269
8208289
8307584
8521505
8673138
8889548
8917514
10583385
10878019
11032890
11118617
12107411
12119397
12477932
15489334
16641997
16892066
17222360
17584859
18240029
20360068
20801516
21139048
21890473
21906983
21963094
21987572
22190596
22505724
23000965
23292452

Gene Ontology  (GO ID)

Biological Process

GO:0008283  cell proliferation
GO:0071257  cellular response to electrical stimulus
GO:0001580  detection of chemical stimulus involved in sensory perception of bitter taste
GO:0050908  detection of light stimulus involved in visual perception
GO:0042462  eye photoreceptor cell development
GO:0007188  G-protein signaling, coupled to cAMP nucleotide second messenger
GO:0051344  negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0007603  phototransduction, visible light
GO:0051343  positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0022400  regulation of rhodopsin mediated signaling pathway
GO:0009642  response to light intensity
GO:0009416  response to light stimulus
GO:0060041  retina development in camera-type eye
GO:0016056  rhodopsin mediated signaling pathway
GO:0050917  sensory perception of umami taste
GO:0007165  signal transduction
GO:0007601  visual perception

Cellular Component

GO:0016324  apical plasma membrane
GO:0043025  cell soma
GO:0005829  cytosol
GO:0031234  extrinsic to internal side of plasma membrane
GO:0005834  heterotrimeric G-protein complex
GO:0016020  membrane
GO:0032391  photoreceptor connecting cilium
GO:0001917  photoreceptor inner segment
GO:0001750  photoreceptor outer segment
GO:0042622  photoreceptor outer segment membrane
GO:0005886  plasma membrane

Molecular Function

GO:0000035  acyl binding
GO:0031683  G-protein beta/gamma-subunit binding
GO:0001664  G-protein-coupled receptor binding
GO:0019003  GDP binding
GO:0005525  GTP binding
GO:0003924  GTPase activity
GO:0046872  metal ion binding
GO:0019901  protein kinase binding
GO:0004871  signal transducer activity