neurotrophin 3

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Synonym

NTF3, Neurotrophin-3 precursor, NGF2, HDNF, Nerve growth factor 2, MGC129711, neurotrophin 3, Neurotrophic factor, NGF-2, NT-3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:11.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:4.80
GeneChip cerebrum:4.91 cerebellum:5.60 brain stem:4.98 corpus callosum/glia:4.85 pineal gland:- peripheral nerve:5.07 spine:4.71 retina:- eye:- artery/aorta:6.06 vein:6.38 lymphnode:5.04 peripheral blood:- spleen:5.34 thymus:4.99 bone marrow:4.93 adipose:5.17 bone:- skin:5.46
CAGE cerebrum:0.53 cerebellum:- brain stem:0.36 corpus callosum/glia:0.29 pineal gland:4.63 peripheral nerve:- spine:0.32 retina:- eye:- artery/aorta:3.80 vein:1.57 lymphnode:0.85 peripheral blood:- spleen:2.15 thymus:0.23 bone marrow:- adipose:1.29 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.41 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.24 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:10.90 prostate:- ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:4.90    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.29 placenta:4.81 prostate:5.25 ovary:5.37 testis:4.85 heart:5.20 muscle:5.46 esophagus:5.23 stomach:5.09 intestine:5.34 colon:5.09 liver/hepato:5.28 lung:4.86 bladder:- kidney:4.93 pituitary:4.91 thyroid/parathyroid:4.75 adrenal gland:5.02 pancreas:5.51 breast:5.35 salivary:5.10
CAGE uterus:2.41 placenta:1.14 prostate:2.22 ovary:2.46 testis:1.44 heart:1.64 muscle:1.26 esophagus:1.48 stomach:- intestine:1.92 colon:1.53     liver/hepato:1.99    lung:1.37 bladder:2.35 kidney:1.53 pituitary:0.32 thyroid/parathyroid:0.57 adrenal gland:- pancreas:0 breast:1.80 salivary:1.67
RNA-seq uterus:- placenta:- prostate:0.99 ovary:0.33 testis:0.23 heart:0.29 muscle:0.57 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.28        lung:0.00    bladder:- kidney:0.38 pituitary:- thyroid/parathyroid:0.18 adrenal gland:0.50 pancreas:- breast:0.57 salivary:-

Gene Information

IDs

Refseq ID NM_002527
Gene ID 4908
Unigene ID Hs.99171
Probe set ID 206706_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000185652
GTEx ID ENSG00000185652

Orthologous Gene

Mouse[3]  NM_001164034, NM_001164035, NM_008742
Rat [0]  

Chromosomal Region

12p13.31  [5,541,278  -  5,630,702]

Gene Family (Interpro ID)

IPR020408  Nerve growth factor-like
IPR015578  Neurotrophin-3

Link to Pubmed  (Pubmed ID)

1542658
1645620
1889806
1889807
2025430
2236018
2344409
2365067
7514502
7703225
7733919
7991545
8621424
8819011
8841198
8925252
9488719
9756741
9973222
11580868
11877300
11920853
12107412
12397373
12477932
12598727
12710933
12900521
15146197
15365216
15474906
15489334
15544837
15589528
15770067
15843147
16441896
16786155
17112518
17192954
17207965
17234344
17698064
18069415
18179783
18203754
18305571
18313696
18336001
18428117
18438927
18438945
18596692
19086053
19357934
19369542
19453261
19598235
19680743
20060128
20160348
20219210
20360537
20379614
20576502
20597688
21085492
21261755
21392742
21698095
21720807
21787840
21996274
22036954
22158057
22192858
22454143
22459634
23001042
23027130
23038618
23075484
23149719
23185507
23426664
23522042
23869086

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0032148  activation of protein kinase B activity
GO:0032856  activation of Ras GTPase activity
GO:0007411  axon guidance
GO:0007420  brain development
GO:0007267  cell-cell signaling
GO:0048484  enteric nervous system development
GO:0008544  epidermis development
GO:0007403  glial cell fate determination
GO:0050930  induction of positive chemotaxis
GO:0042490  mechanoreceptor differentiation
GO:0042552  myelination
GO:0043524  negative regulation of neuron apoptosis
GO:0050732  negative regulation of peptidyl-tyrosine phosphorylation
GO:0021675  nerve development
GO:0007399  nervous system development
GO:0007274  neuromuscular synaptic transmission
GO:0007422  peripheral nervous system development
GO:0050918  positive chemotaxis
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0045687  positive regulation of glial cell differentiation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0002092  positive regulation of receptor internalization
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0050804  regulation of synaptic transmission
GO:0007165  signal transduction
GO:0051145  smooth muscle cell differentiation
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0005576  extracellular region

Molecular Function

GO:0042056  chemoattractant activity
GO:0008083  growth factor activity
GO:0048406  nerve growth factor binding
GO:0005165  neurotrophin receptor binding
GO:0005102  receptor binding