phospholipase C, epsilon 1

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Synonym

FLJ23659, PLCE1, KIAA1516, phospholipase C, epsilon 1, PLCE

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:4.76 cerebellum:4.25 brain stem:4.89 corpus callosum/glia:4.87 pineal gland:- peripheral nerve:5.74 spine:5.08 retina:- eye:- artery/aorta:5.72 vein:5.33 lymphnode:4.14 peripheral blood:- spleen:5.36 thymus:3.99 bone marrow:4.18 adipose:4.75 bone:- skin:4.70
CAGE cerebrum:2.30 cerebellum:- brain stem:2.30 corpus callosum/glia:2.77 pineal gland:4.10 peripheral nerve:- spine:2.67 retina:- eye:- artery/aorta:3.15 vein:1.17 lymphnode:0.78 peripheral blood:- spleen:2.75 thymus:0.61 bone marrow:- adipose:1.86 bone:- skin:-
RNA-seq cerebrum:1.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.90 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.63 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:5.84 placenta:4.62 prostate:4.98 ovary:5.12 testis:4.74 heart:5.67 muscle:4.69 esophagus:4.55 stomach:5.34 intestine:5.39 colon:5.73 liver/hepato:4.14 lung:5.11 bladder:- kidney:4.84 pituitary:4.83 thyroid/parathyroid:5.10 adrenal gland:4.26 pancreas:6 breast:4.49 salivary:4.52
CAGE uterus:3.40 placenta:1.25 prostate:2.46 ovary:2.40 testis:1.49 heart:2.87 muscle:2.24 esophagus:2.12 stomach:- intestine:2.50 colon:3.52     liver/hepato:0.63    lung:2.61 bladder:2.52 kidney:2.03 pituitary:2.70 thyroid/parathyroid:3.39 adrenal gland:- pancreas:0.94 breast:2.27 salivary:1.82
RNA-seq uterus:- placenta:- prostate:1.75 ovary:1.57 testis:1.51 heart:1.67 muscle:1.07 esophagus:- stomach:- intestine:- colon:2.04     liver/hepato:0.10        lung:2.14    bladder:- kidney:2.16 pituitary:- thyroid/parathyroid:2.82 adrenal gland:0.72 pancreas:- breast:1.09 salivary:-

Gene Information

IDs

Refseq ID NM_001165979
Gene ID 51196
Unigene ID -
Probe set ID 205112_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000138193
GTEx ID ENSG00000138193

Orthologous Gene

Mouse[1]  NM_019588
Rat[1]  NM_053758

Chromosomal Region

10q23.33  [95,753,746  -  96,088,149]

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR018029  C2 membrane targeting protein

Link to Pubmed  (Pubmed ID)

1979339
7589147
9278385
9730685
10501179
10819331
10843712
11022047
11022048
11395506
11715024
11877431
12444546
12477932
12482669
12721365
12878163
14702039
15157671
15164054
15558028
16169070
16293787
16385451
16483931
16537651
16565089
17086182
17373700
17449496
17942568
17998205
18029348
18065803
18270750
18975016
19037252
19260473
19875381
20056178
20201926
20336759
20379614
20507940
20591883
20620593
20677014
20729852
20729853
21365190
21368711
21642993
21658281
21667163
21685187
21689432
21705050
21837401
21909110
21909115
21909432
21951843
22001756
22203178
22412849
22744421
22805490
22865593
23079034
23222411
23390063
23536857
23659763
23688607
23797815
23826241
23874915
23958207
23975622
23981775
24146276
24254309
24591640

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0007200  activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
GO:0007205  activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0019722  calcium-mediated signaling
GO:0008283  cell proliferation
GO:0007010  cytoskeleton organization
GO:0006651  diacylglycerol biosynthetic process
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0032835  glomerulus development
GO:0007507  heart development
GO:0043647  inositol phosphate metabolic process
GO:0048016  inositol phosphate-mediated signaling
GO:0016042  lipid catabolic process
GO:0006644  phospholipid metabolic process
GO:0007265  Ras protein signal transduction
GO:0001558  regulation of cell growth
GO:0008277  regulation of G-protein coupled receptor protein signaling pathway
GO:0045859  regulation of protein kinase activity
GO:0046578  regulation of Ras protein signal transduction
GO:0006940  regulation of smooth muscle contraction

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0000139  Golgi membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005509  calcium ion binding
GO:0019899  enzyme binding
GO:0005085  guanyl-nucleotide exchange factor activity
GO:0004435  phosphoinositide phospholipase C activity
GO:0004629  phospholipase C activity
GO:0005515  protein binding
GO:0017016  Ras GTPase binding
GO:0005057  receptor signaling protein activity