tribbles homolog 3 (Drosophila)

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Synonym

TRIB3, SKIP3, NIPK, Tribbles homolog 3, SINK, TRB3, chromosome 20 open reading frame 97, Neuronal cell death-inducible putative kinase, dJ1103G7.3, tribbles homolog 3 (Drosophila), C20orf97, p65-interacting inhibitor of NF-kappaB, TRB-3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:7.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:47 artery/aorta:- vein:66.60 lymphnode:- peripheral blood:72.90 spleen:18.90 thymus:12.90 bone marrow:- adipose:- bone:- skin:43.20
GeneChip cerebrum:5.49 cerebellum:5.90 brain stem:5.41 corpus callosum/glia:5.36 pineal gland:- peripheral nerve:5.85 spine:5.59 retina:- eye:- artery/aorta:5.75 vein:5.67 lymphnode:6.09 peripheral blood:- spleen:6.58 thymus:6.26 bone marrow:6.07 adipose:6.10 bone:- skin:6.03
CAGE cerebrum:1.20 cerebellum:- brain stem:0.91 corpus callosum/glia:1.01 pineal gland:2.82 peripheral nerve:- spine:0.39 retina:- eye:- artery/aorta:1.52 vein:2.22 lymphnode:2.34 peripheral blood:- spleen:2.45 thymus:2.20 bone marrow:- adipose:2.14 bone:- skin:-
RNA-seq cerebrum:0.68 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.86 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.43 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:37.30 testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:42.40     liver/hepato:21.10        lung:14.70    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:17.80 breast:102.20 salivary:-
GeneChip uterus:5.54 placenta:5.74 prostate:6.18 ovary:5.60 testis:5.32 heart:5.55 muscle:5.38 esophagus:6.39 stomach:6.02 intestine:5.94 colon:6 liver/hepato:7.25 lung:5.98 bladder:- kidney:5.57 pituitary:6.32 thyroid/parathyroid:5.93 adrenal gland:6.04 pancreas:6.26 breast:6.42 salivary:6.36
CAGE uterus:1.47 placenta:2.22 prostate:1.88 ovary:1.95 testis:1.57 heart:1.55 muscle:0.81 esophagus:2.08 stomach:- intestine:1.05 colon:0.96     liver/hepato:3.76    lung:2.26 bladder:1.64 kidney:1.51 pituitary:2.73 thyroid/parathyroid:2.77 adrenal gland:- pancreas:2.94 breast:2.27 salivary:2.53
RNA-seq uterus:- placenta:- prostate:1.33 ovary:1.62 testis:0.98 heart:0.44 muscle:0.96 esophagus:- stomach:- intestine:- colon:1.33     liver/hepato:4.15        lung:2.07    bladder:- kidney:1.25 pituitary:- thyroid/parathyroid:1.83 adrenal gland:2.42 pancreas:- breast:0.97 salivary:-

Gene Information

IDs

Refseq ID NM_021158
Gene ID 57761
Unigene ID Hs.516826
Probe set ID 218145_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000101255
GTEx ID ENSG00000101255

Orthologous Gene

Mouse[2]  NM_175093
Rat [0]  

Chromosomal Region

20p13  [361,261  -  378,203]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain

Link to Pubmed  (Pubmed ID)

8125298
11780052
12477932
12736262
12743605
12791994
13679039
14702039
15299019
15489334
15775988
15781252
16123373
16129579
16147992
16169070
16715410
16794074
16887816
16966378
17112672
17369260
17576771
17576816
17707795
17872950
18029348
18187772
18276110
18408768
18436806
18660489
18984671
19139803
19180501
19291425
19389115
19389818
19505541
19904274
19913121
20064487
20139130
20393693
20461355
20592469
20606298
20628086
20693163
21130836
21203563
21220698
21435438
21492415
21572435
21704407
21832049
21864376
21896644
21935927
22274752
22577090
22912727
22977230
23185332
23319603
23349842
23455924
23550039
23632994
23695665

Gene Ontology  (GO ID)

Biological Process

GO:0070059  apoptosis in response to endoplasmic reticulum stress
GO:0044255  cellular lipid metabolic process
GO:0032869  cellular response to insulin stimulus
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0045599  negative regulation of fat cell differentiation
GO:0045717  negative regulation of fatty acid biosynthetic process
GO:0006469  negative regulation of protein kinase activity
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0048011  nerve growth factor receptor signaling pathway
GO:0048015  phosphoinositide-mediated signaling
GO:0032092  positive regulation of protein binding
GO:0051443  positive regulation of ubiquitin-protein ligase activity
GO:0006468  protein amino acid phosphorylation
GO:0010827  regulation of glucose transport
GO:0043405  regulation of MAP kinase activity
GO:0034976  response to endoplasmic reticulum stress
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005829  cytosol
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0016301  kinase activity
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004860  protein kinase inhibitor activity
GO:0003714  transcription corepressor activity
GO:0031625  ubiquitin protein ligase binding
GO:0055106  ubiquitin-protein ligase regulator activity