ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

Synonym

RNase L, 2-5A-dependent ribonuclease, MGC104972, RNASEL, DKFZp781D08126, 2-5A-dependent RNase, MGC133329, PRCA1, RNS4, Ribonuclease L, Ribonuclease 4

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:3.60

cerebellum:12.60

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:-

retina:-

eye:-

artery/aorta:60

vein:-

lymphnode:30.30

peripheral blood:-

spleen:-

thymus:-

bone marrow:59

adipose:-

bone:25.60

skin:9.60

GeneChip

cerebrum:5.62

cerebellum:5.36

brain stem:5.70

corpus callosum/glia:5.39

pineal gland:-

peripheral nerve:5.76

spine:5.55

retina:-

eye:-

artery/aorta:5.71

vein:5.70

lymphnode:5.76

peripheral blood:-

spleen:5.90

thymus:5.96

bone marrow:6.07

adipose:5.70

bone:-

skin:5.46

CAGE

cerebrum:2.03

cerebellum:-

brain stem:2.45

corpus callosum/glia:2.13

pineal gland:2.99

peripheral nerve:-

spine:2.30

retina:-

eye:-

artery/aorta:2.28

vein:2.11

lymphnode:2.47

peripheral blood:-

spleen:2.53

thymus:2.62

bone marrow:-

adipose:2.45

bone:-

skin:-

RNA-seq

cerebrum:1.27

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.62

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:1.83

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:9.10

placenta:7.30

prostate:67.60

ovary:-

testis:4.30

heart:25.50

muscle:-

esophagus:-

stomach:21.20

intestine:64.80

colon:-

liver/hepato:10.60

lung:24.40

bladder:-

kidney:10.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:101.60

pancreas:-

breast:-

salivary:-

GeneChip

uterus:5.66

placenta:5.42

prostate:5.56

ovary:5.64

testis:5.18

heart:5.75

muscle:5.56

esophagus:5.53

stomach:5.74

intestine:5.60

colon:5.87

liver/hepato:5.58

lung:5.68

bladder:-

kidney:5.83

pituitary:5.72

thyroid/parathyroid:5.84

adrenal gland:5.97

pancreas:5.84

breast:5.55

salivary:5.56

CAGE

uterus:2.79

placenta:2.38

prostate:2.60

ovary:2.54

testis:1.82

heart:1.74

muscle:1.18

esophagus:2.52

stomach:-

intestine:2.68

colon:2.41

liver/hepato:1.63

lung:2.39

bladder:2.57

kidney:2.46

pituitary:2.82

thyroid/parathyroid:2.69

adrenal gland:-

pancreas:0.58

breast:2.19

salivary:1.89

RNA-seq

uterus:-

placenta:-

prostate:2.80

ovary:2.68

testis:1.78

heart:1.02

muscle:0.62

esophagus:-

stomach:-

intestine:-

colon:2.18

liver/hepato:0.95

lung:1.48

bladder:-

kidney:2.53

pituitary:-

thyroid/parathyroid:2.18

adrenal gland:1.91

pancreas:-

breast:2.03

salivary:-

IDs

Refseq ID	NM_021133
Gene ID	6041
Unigene ID	Hs.518545
Probe set ID	221287_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000135828
GTEx ID	ENSG00000135828

Orthologous Gene

Mouse[2]	NM_011882
Rat[1]	NM_182673

Chromosomal Region

1q25.3 [182,542,769 - 182,558,391]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR006567	PUG domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain

GO:0019221	cytokine-mediated signaling pathway
GO:0051607	defense response to virus
GO:0006397	mRNA processing
GO:0045071	negative regulation of viral genome replication
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0006468	protein amino acid phosphorylation
GO:0060337	type I interferon-mediated signaling pathway

GO:0005575	cellular_component
GO:0005829	cytosol
GO:0005739	mitochondrion

GO:0005524	ATP binding
GO:0004521	endoribonuclease activity
GO:0046872	metal ion binding
GO:0004672	protein kinase activity
GO:0003723	RNA binding

ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function