HtrA serine peptidase 3

 jump to detail

Synonym

PRSP, High-temperature requirement factor A3, Prsp, HtrA serine peptidase 3, Tasp, Probable serine protease HTRA3 precursor, Pregnancy-related serine protease, HTRA3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:7.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:148.30 peripheral nerve:30.70 spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:36.40 spleen:- thymus:12.90 bone marrow:59 adipose:40.30 bone:51.20 skin:-
GeneChip nodata
CAGE cerebrum:0.34 cerebellum:- brain stem:0.55 corpus callosum/glia:0.47 pineal gland:1.59 peripheral nerve:- spine:0.42 retina:- eye:- artery/aorta:3.55 vein:3.41 lymphnode:1.67 peripheral blood:- spleen:1.09 thymus:0.74 bone marrow:- adipose:3.49 bone:- skin:-
RNA-seq cerebrum:0.23 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.12 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.37 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:40.10 prostate:22.50 ovary:223.60 testis:4.30 heart:153.30 muscle:40.20 esophagus:- stomach:21.20 intestine:- colon:17     liver/hepato:-        lung:14.70    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:139.40 salivary:-
GeneChip nodata
CAGE uterus:3.11 placenta:2.52 prostate:3.06 ovary:3.52 testis:2.24 heart:4.17 muscle:2.13 esophagus:2.99 stomach:- intestine:2.25 colon:2.92     liver/hepato:0.84    lung:3.24 bladder:3.64 kidney:1.01 pituitary:1.36 thyroid/parathyroid:2.49 adrenal gland:- pancreas:1.42 breast:3.90 salivary:1.95
RNA-seq uterus:- placenta:- prostate:4.11 ovary:4.11 testis:2.37 heart:3.36 muscle:2.30 esophagus:- stomach:- intestine:- colon:3.79     liver/hepato:0.59        lung:4.31    bladder:- kidney:1.44 pituitary:- thyroid/parathyroid:2.64 adrenal gland:1.46 pancreas:- breast:4.04 salivary:-

Gene Information

IDs

Refseq ID NM_053044
Gene ID 94031
Unigene ID Hs.479119
Probe set ID -
Ensembl ID ENSG00000170801
GTEx ID ENSG00000170801

Orthologous Gene

Mouse[2]  NM_001042615, NM_030127
Rat[2]  NM_001042615, NM_030127

Chromosomal Region

4p16.1  [8,271,492  -  8,308,838]

Gene Family (Interpro ID)

IPR001940  Peptidase S1C, HrtA/DegP2/Q/S
IPR002350  Proteinase inhibitor I1, Kazal

Link to Pubmed  (Pubmed ID)

12477932
12513693
14500695
15489334
16251496
16650464
17962403
18241672
18387192
19359045
19424634
19951697
20068077
20154083
20379614
20469960
21035848
21047919
21321049
21555518
22923201
23049902
23812730

Gene Ontology  (GO ID)

Biological Process

GO:0030514  negative regulation of BMP signaling pathway
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0006508  proteolysis
GO:0001558  regulation of cell growth

Cellular Component

GO:0005576  extracellular region

Molecular Function

GO:0004175  endopeptidase activity
GO:0005520  insulin-like growth factor binding
GO:0005515  protein binding
GO:0004252  serine-type endopeptidase activity
GO:0008236  serine-type peptidase activity