glutamyl-prolyl-tRNA synthetase

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Synonym

2410081F06Rik, Qprs, 3010002K18Rik, glutamyl-prolyl-tRNA synthetase, C79379, Eprs, Bifunctional aminoacyl-tRNA synthetase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:189.30 cerebellum:73.70 brain stem:127.10 corpus callosum/glia:- pineal gland:- peripheral nerve:76.40 spine:331 retina:128.60 eye:228 artery/aorta:168.80 vein:- lymphnode:32.40 peripheral blood:1107 spleen:65.80 thymus:138.30 bone marrow:12.80 adipose:- bone:288.10 skin:356.30
GeneChip cerebrum:8.19 cerebellum:8.50 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:9.22 spine:8.34 retina:8.48 eye:8.17 artery/aorta:- vein:9.16 lymphnode:8.72 peripheral blood:- spleen:8.36 thymus:- bone marrow:8.73 adipose:8.82 bone:8.90 skin:8.93
CAGE nodata
RNA-seq cerebrum:5.94 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:261.70 placenta:372.80 prostate:185.30 ovary:160.90 testis:192.10 heart:130.20 muscle:284.10 esophagus:- stomach:32.70 intestine:37 colon:17.60     liver/hepato:9.10        lung:291.20    bladder:- kidney:72.50 pituitary:271.30 thyroid/parathyroid:224.90 adrenal gland:- pancreas:309.60 breast:179.60 salivary:54
GeneChip uterus:8.77 placenta:8.71 prostate:9.04 ovary:8.89 testis:8.27 heart:8.45 muscle:10.22 esophagus:- stomach:8.27 intestine:8.64 colon:- liver/hepato:9.20 lung:8.37 bladder:8.63 kidney:8.40 pituitary:10.25 thyroid/parathyroid:- adrenal gland:10.87 pancreas:9.38 breast:9.17 salivary:10.38
CAGE nodata
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:10.88 esophagus:- stomach:- intestine:- colon:-     liver/hepato:13.12        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_029735
Gene ID 107508
Unigene ID Mm.154511
Probe set ID 1426713_s_at  [Mouse430_2]
Ensembl ID ENSMUSG00000026615

Orthologous Gene

Human[3]  NM_004446
Rat[1]  NM_001024238

Chromosomal Region

-

Gene Family (Interpro ID)

IPR002314  Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain
IPR006195  Aminoacyl-tRNA synthetase, class II, conserved domain
IPR004526  Glutamyl-tRNA synthetase, class Ic, archaeal/eukaryotic cytosolic
IPR000924  Glutamyl/glutaminyl-tRNA synthetase, class Ic
IPR017449  Prolyl-tRNA synthetase, class II
IPR016061  Prolyl-tRNA synthetase, class II, C-terminal
IPR002316  Prolyl-tRNA synthetase, class IIa, conserved region
IPR009068  S15/NS1, RNA-binding
IPR000738  WHEP-TRS

Link to Pubmed  (Pubmed ID)

1988429
8188258
10349636
10725249
10922068
11042159
11076861
11217851
11544199
12466851
12477932
12520002
12904583
14610273
14681479
15489334
15782199
16141072
16141073
16602821
17967808
18799693
21267068
21565611
21652651
22673621
23071094
23649778
24457600

Gene Ontology  (GO ID)

Biological Process

GO:0071346  cellular response to interferon-gamma
GO:0006424  glutamyl-tRNA aminoacylation
GO:0008152  metabolic process
GO:0017148  negative regulation of translation
GO:0006433  prolyl-tRNA aminoacylation
GO:0006417  regulation of translation
GO:0006412  translation
GO:0043039  tRNA aminoacylation
GO:0006418  tRNA aminoacylation for protein translation

Cellular Component

GO:0005737  cytoplasm
GO:0030529  ribonucleoprotein complex

Molecular Function

GO:0004812  aminoacyl-tRNA ligase activity
GO:0005524  ATP binding
GO:0003824  catalytic activity
GO:0004818  glutamate-tRNA ligase activity
GO:0016874  ligase activity
GO:0016876  ligase activity, forming aminoacyl-tRNA and related compounds
GO:0000166  nucleotide binding
GO:0004827  proline-tRNA ligase activity
GO:0003723  RNA binding