cholinergic receptor, nicotinic, alpha polypeptide 3

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Synonym

Acra3, Chrna3, alpha 3, Acra-3, A730007P14Rik, (a)3

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12.20 cerebellum:552.60 brain stem:127.10 corpus callosum/glia:- pineal gland:257.80 peripheral nerve:152.90 spine:47.30 retina:225 eye:60.80 artery/aorta:168.80 vein:- lymphnode:- peripheral blood:43.10 spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.43 cerebellum:4.37 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.48 spine:4.58 retina:4.52 eye:4.39 artery/aorta:- vein:4.27 lymphnode:4.10 peripheral blood:- spleen:4.12 thymus:- bone marrow:4.10 adipose:4.17 bone:4.14 skin:4.25
CAGE cerebrum:0.45 cerebellum:- brain stem:1.86 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:1.70 retina:- eye:- artery/aorta:1.11 vein:- lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:- bone:0 skin:0
RNA-seq cerebrum:1.00 cerebellum:1.00 brain stem:1.00 corpus callosum/glia:1.00 pineal gland:1.00 peripheral nerve:1.00 spine:1.00 retina:1.00 eye:1.00 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:10    bladder:66.20 kidney:- pituitary:12.90 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.11 placenta:4.52 prostate:4.28 ovary:4.01 testis:4.33 heart:4.46 muscle:4.22 esophagus:- stomach:4.60 intestine:4.83 colon:- liver/hepato:4.41 lung:4.07 bladder:4.32 kidney:4.24 pituitary:4.36 thyroid/parathyroid:- adrenal gland:6.95 pancreas:4.70 breast:4.21 salivary:4.02
CAGE uterus:0 placenta:0.11 prostate:2.51 ovary:0 testis:0 heart:- muscle:- esophagus:- stomach:1.07 intestine:1.36 colon:1.46     liver/hepato:0    lung:0.31 bladder:2.56 kidney:- pituitary:0.52 thyroid/parathyroid:- adrenal gland:3.62 pancreas:0 breast:0.12 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_145129
Gene ID 110834
Unigene ID Mm.63569
Probe set ID 1455931_at  [Mouse430_2]
Ensembl ID ENSMUSG00000032303

Orthologous Gene

Human[4]  NM_000743, NM_001166694
Rat[1]  NM_052805, NM_001166694

Chromosomal Region

-

Gene Family (Interpro ID)

IPR006201  Neurotransmitter-gated ion-channel

Link to Pubmed  (Pubmed ID)

1505988
2004777
2338144
8563774
8630490
8748389
8838678
9023306
10095079
10318955
10349636
10771006
11027228
11042159
11076861
11217851
11923417
12225896
12438103
12466851
12477932
15275829
15681842
16141072
16141073
16162937
16602821
17434683
17504758
18279314
18568021
18826434
19186169
19474315
19640321
19906978
20128845
20496163
20620869
21267068
22378897
22380605
22647603
23213462
23416040
24049141

Gene Ontology  (GO ID)

Biological Process

GO:0007171  activation of transmembrane receptor protein tyrosine kinase activity
GO:0035095  behavioral response to nicotine
GO:0006812  cation transport
GO:0034220  ion transmembrane transport
GO:0006811  ion transport
GO:0007626  locomotory behavior
GO:0007399  nervous system development
GO:0051291  protein heterooligomerization
GO:0014056  regulation of acetylcholine secretion
GO:0048814  regulation of dendrite morphogenesis
GO:0060079  regulation of excitatory postsynaptic membrane potential
GO:0042391  regulation of membrane potential
GO:0006937  regulation of muscle contraction
GO:0006940  regulation of smooth muscle contraction
GO:0042493  response to drug
GO:0007165  signal transduction
GO:0060084  synaptic transmission involved in micturition
GO:0007271  synaptic transmission, cholinergic
GO:0006810  transport

Cellular Component

GO:0030054  cell junction
GO:0043025  cell soma
GO:0030425  dendrite
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0005892  nicotinic acetylcholine-gated receptor-channel complex
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane
GO:0045202  synapse

Molecular Function

GO:0042166  acetylcholine binding
GO:0015464  acetylcholine receptor activity
GO:0008144  drug binding
GO:0005230  extracellular ligand-gated ion channel activity
GO:0005216  ion channel activity
GO:0004889  nicotinic acetylcholine-activated cation-selective channel activity
GO:0005515  protein binding