cyclin-dependent kinase 6

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Synonym

cyclin-dependent kinase 6, 5830411I20, Cell division protein kinase 6, Crk2, CRK2, Cdk6, Serine/threonine-protein kinase PLSTIRE, AI504062

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:33 cerebellum:73.70 brain stem:158.90 corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:- retina:32.10 eye:76 artery/aorta:- vein:- lymphnode:- peripheral blood:28.80 spleen:- thymus:39.50 bone marrow:- adipose:- bone:50.10 skin:15.80
GeneChip cerebrum:4.76 cerebellum:4.69 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.70 spine:4.93 retina:5.05 eye:5.33 artery/aorta:- vein:5.34 lymphnode:4.85 peripheral blood:- spleen:4.90 thymus:- bone marrow:6.59 adipose:5.23 bone:5.73 skin:5.28
CAGE cerebrum:0.43 cerebellum:- brain stem:0.42 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.32 retina:- eye:- artery/aorta:2.16 vein:- lymphnode:2.01 peripheral blood:- spleen:1.78 thymus:2.11 bone marrow:- adipose:- bone:2.83 skin:1.81
RNA-seq cerebrum:1.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:27.60 prostate:30.90 ovary:23 testis:14.80 heart:93 muscle:- esophagus:- stomach:- intestine:- colon:17.60     liver/hepato:9.10        lung:60.30    bladder:66.20 kidney:- pituitary:12.90 thyroid/parathyroid:- adrenal gland:- pancreas:65.70 breast:45.70 salivary:-
GeneChip uterus:5.19 placenta:5.47 prostate:5.09 ovary:5.14 testis:4.85 heart:5.32 muscle:4.81 esophagus:- stomach:5.07 intestine:5.14 colon:- liver/hepato:5.67 lung:5.08 bladder:4.84 kidney:5.46 pituitary:4.75 thyroid/parathyroid:- adrenal gland:4.80 pancreas:5.31 breast:5.15 salivary:4.84
CAGE uterus:2.10 placenta:1.58 prostate:1.02 ovary:2.09 testis:0.75 heart:- muscle:- esophagus:- stomach:0 intestine:1.60 colon:1.03     liver/hepato:1.02    lung:2.10 bladder:1.76 kidney:- pituitary:1.22 thyroid/parathyroid:- adrenal gland:1.77 pancreas:0.84 breast:1.99 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.18 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.76        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_009873
Gene ID 12571
Unigene ID Mm.316728
Probe set ID 1460291_at  [Mouse430_2]
Ensembl ID ENSMUSG00000040274

Orthologous Gene

Human[2]  NM_001145306, NM_001259
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1459009
1639063
7651726
8444355
8822197
8889548
9372237
9584157
9664690
10349636
10384057
10915795
10922068
11042159
11076861
11217851
11254678
11544199
11707776
11804782
12007403
12196289
12215429
12466851
12477932
12520002
12592386
12833137
12861051
13679319
14500367
14610273
14630948
14647273
14724578
15062102
15254224
15315760
15315761
15738651
15761153
15782199
15795936
16102793
16141072
16141073
16169709
16413468
16602821
16678773
16767702
16869759
17431401
17699765
17700700
18191580
19040567
19155308
19265663
19501046
19667758
19860623
19955566
20100483
20354191
20534551
20609353
20609517
21135503
21224071
21300982
21319271
21508411
21628465
21652635
21677750
22241836
22325351
22465667
22564414
22898775
22922362
23079656
23159226
23342106
23622063
23624920
23684768
23803733
23839966
23888052
23918663
23948297

Gene Ontology  (GO ID)

Biological Process

GO:0007049  cell cycle
GO:0043697  cell dedifferentiation
GO:0030154  cell differentiation
GO:0051301  cell division
GO:0042063  gliogenesis
GO:0030097  hemopoiesis
GO:0002244  hemopoietic progenitor cell differentiation
GO:0060218  hemopoietic stem cell differentiation
GO:0045786  negative regulation of cell cycle
GO:0050680  negative regulation of epithelial cell proliferation
GO:0045638  negative regulation of myeloid cell differentiation
GO:0045668  negative regulation of osteoblast differentiation
GO:0007219  Notch signaling pathway
GO:0003323  pancreatic B cell development
GO:0016310  phosphorylation
GO:0001954  positive regulation of cell-matrix adhesion
GO:0048146  positive regulation of fibroblast proliferation
GO:0010628  positive regulation of gene expression
GO:0006468  protein amino acid phosphorylation
GO:0045646  regulation of erythrocyte differentiation
GO:0010468  regulation of gene expression
GO:0033077  T cell differentiation in the thymus

Cellular Component

GO:0042995  cell projection
GO:0000307  cyclin-dependent protein kinase holoenzyme complex
GO:0005737  cytoplasm
GO:0005634  nucleus
GO:0001726  ruffle

Molecular Function

GO:0005524  ATP binding
GO:0030332  cyclin binding
GO:0004693  cyclin-dependent protein kinase activity
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups