excision repair cross-complementing rodent repair deficiency, complementation group 1

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Synonym

DNA excision repair protein ERCC-1, Ercc-1, Ercc1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:52.10 cerebellum:165.80 brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:47.30 retina:- eye:22.80 artery/aorta:- vein:- lymphnode:- peripheral blood:14.40 spleen:- thymus:79 bone marrow:- adipose:- bone:112.70 skin:55.40
GeneChip cerebrum:7.71 cerebellum:7.59 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.99 spine:7.73 retina:6.38 eye:6.65 artery/aorta:- vein:8.07 lymphnode:7.69 peripheral blood:- spleen:7.46 thymus:- bone marrow:7.16 adipose:8.07 bone:6.98 skin:7.27
CAGE cerebrum:3.50 cerebellum:- brain stem:3.47 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.40 retina:- eye:- artery/aorta:3.32 vein:- lymphnode:3.21 peripheral blood:- spleen:3.17 thymus:3.52 bone marrow:- adipose:- bone:3.18 skin:3.42
RNA-seq cerebrum:6.34 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:69 prostate:- ovary:11.50 testis:22.20 heart:111.60 muscle:177.50 esophagus:- stomach:32.70 intestine:- colon:-     liver/hepato:9.10        lung:120.50    bladder:- kidney:24.20 pituitary:64.60 thyroid/parathyroid:224.90 adrenal gland:- pancreas:9.40 breast:32.60 salivary:-
GeneChip uterus:7.90 placenta:9.02 prostate:7.44 ovary:7.80 testis:8.79 heart:8.06 muscle:8.30 esophagus:- stomach:7.52 intestine:7.16 colon:- liver/hepato:6.97 lung:7.76 bladder:7.94 kidney:7.05 pituitary:7.45 thyroid/parathyroid:- adrenal gland:7.60 pancreas:7.03 breast:7.88 salivary:7.20
CAGE uterus:3.34 placenta:3.21 prostate:3.33 ovary:3.48 testis:5.06 heart:- muscle:- esophagus:- stomach:2.90 intestine:2.64 colon:2.92     liver/hepato:2.70    lung:3.52 bladder:3.52 kidney:- pituitary:3.35 thyroid/parathyroid:- adrenal gland:3.32 pancreas:3.32 breast:2.65 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:4.91 esophagus:- stomach:- intestine:- colon:-     liver/hepato:4.18        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_007948
Gene ID 13870
Unigene ID Mm.280913
Probe set ID 1417328_at  [Mouse430_2]
Ensembl ID ENSMUSG00000003549

Orthologous Gene

Human[5]  NM_001166049, NM_001983, NM_202001
Rat[1]  NM_001106228, NM_001983, NM_202001

Chromosomal Region

7A3  [19,930,127  -  19,941,873]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1730160
1981054
2558854
3290851
3919454
8275084
8287470
8889548
9197240
10214917
10349636
10454634
10834928
10922068
11042159
11076861
11217851
11239426
11707424
11713303
12466203
12466851
12477932
12520002
12713813
14610273
14651920
14690602
15199134
15280420
15688021
15692571
15979950
16141072
16141073
16472827
16682947
17126084
17173483
17183314
17912366
18221731
18541667
18799693
19124610
19805513
20362516
20407824
20507129
20595612
20602234
20798040
21677750
21722328
21880916
22234173
22245387
22257940
22323595
22581771
22701168
22705887
22706308
22953029
23097336
23637614
23648546
23947592
24011075

Gene Ontology  (GO ID)

Biological Process

GO:0048468  cell development
GO:0008283  cell proliferation
GO:0051276  chromosome organization
GO:0006310  DNA recombination
GO:0006281  DNA repair
GO:0006302  double-strand break repair
GO:0007281  germ cell development
GO:0045190  isotype switching
GO:0008584  male gonad development
GO:0006312  mitotic recombination
GO:0035264  multicellular organism growth
GO:0010259  multicellular organismal aging
GO:0032205  negative regulation of telomere maintenance
GO:0006289  nucleotide-excision repair
GO:0006295  nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296  nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0048477  oogenesis
GO:0035166  post-embryonic hemopoiesis
GO:0000720  pyrimidine dimer repair by nucleotide-excision repair
GO:0001302  replicative cell aging
GO:0006974  response to DNA damage stimulus
GO:0006979  response to oxidative stress
GO:0010165  response to X-ray
GO:0007283  spermatogenesis
GO:0006949  syncytium formation
GO:0009650  UV protection

Cellular Component

GO:0005737  cytoplasm
GO:0000784  nuclear chromosome, telomeric region
GO:0000109  nucleotide-excision repair complex
GO:0005634  nucleus
GO:0005669  transcription factor TFIID complex

Molecular Function

GO:0003684  damaged DNA binding
GO:0003677  DNA binding
GO:0004519  endonuclease activity
GO:0016787  hydrolase activity
GO:0004518  nuclease activity
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0019904  protein domain specific binding
GO:0003697  single-stranded DNA binding
GO:0000014  single-stranded DNA specific endodeoxyribonuclease activity
GO:0043566  structure-specific DNA binding
GO:0017025  TATA-binding protein binding