Janus kinase 3

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Synonym

wil, Jak3, JAK-3, Janus kinase 3, Tyrosine-protein kinase JAK3, fae

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:8.70

cerebellum:18.40

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:152.90

spine:-

retina:32.10

eye:-

artery/aorta:-

vein:-

lymphnode:140.40

peripheral blood:776.40

spleen:316

thymus:168

bone marrow:38.50

adipose:212.70

bone:-

skin:7.90

GeneChip

cerebrum:5.75

cerebellum:5.88

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:5.60

spine:6.02

retina:5.68

eye:6

artery/aorta:-

vein:5.77

lymphnode:8.87

peripheral blood:-

spleen:8.33

thymus:-

bone marrow:6.93

adipose:6.89

bone:6.25

skin:5.71

CAGE

cerebrum:0.94

cerebellum:-

brain stem:1.46

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:1.38

retina:-

eye:-

artery/aorta:2.95

vein:-

lymphnode:4.12

peripheral blood:-

spleen:3.33

thymus:2.78

bone marrow:-

adipose:-

bone:2.59

skin:1.42

RNA-seq

cerebrum:1.42

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:69

prostate:-

ovary:23

testis:44.30

heart:74.40

muscle:-

esophagus:-

stomach:-

intestine:-

colon:17.60

liver/hepato:-

lung:60.30

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:848.90

pancreas:-

breast:42.40

salivary:108

GeneChip

uterus:7.13

placenta:6.46

prostate:5.68

ovary:6.11

testis:7.13

heart:6.76

muscle:6.57

esophagus:-

stomach:6.26

intestine:6.42

colon:-

liver/hepato:6.28

lung:7.45

bladder:6.32

kidney:6.19

pituitary:5.92

thyroid/parathyroid:-

adrenal gland:6

pancreas:6.61

breast:6.65

salivary:6.20

CAGE

uterus:3.09

placenta:2.94

prostate:0.74

ovary:2.09

testis:0.75

heart:-

muscle:-

esophagus:-

stomach:1.91

intestine:2.22

colon:2.24

liver/hepato:2.13

lung:3.47

bladder:2.40

kidney:-

pituitary:1.81

thyroid/parathyroid:-

adrenal gland:2.84

pancreas:1.30

breast:2.87

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.67

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:1.98

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_010589
Gene ID	16453
Unigene ID	Mm.249645
Probe set ID	1425750_a_at [Mouse430_2]
Ensembl ID	ENSMUSG00000031805

Orthologous Gene

Human[2]	NM_000215
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0030183	B cell differentiation
GO:0019221	cytokine-mediated signaling pathway
GO:0007204	elevation of cytosolic calcium ion concentration
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0045087	innate immune response
GO:0048535	lymph node development
GO:0002731	negative regulation of dendritic cell cytokine production
GO:0045221	negative regulation of FasL biosynthetic process
GO:0032693	negative regulation of interleukin-10 production
GO:0032695	negative regulation of interleukin-12 production
GO:0050868	negative regulation of T cell activation
GO:0045626	negative regulation of T-helper 1 cell differentiation
GO:0070244	negative regulation of thymocyte apoptosis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0016310	phosphorylation
GO:0042104	positive regulation of activated T cell proliferation
GO:0051928	positive regulation of calcium ion transport
GO:0050778	positive regulation of immune response
GO:0042102	positive regulation of T cell proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0007243	protein kinase cascade
GO:0070232	regulation of T cell apoptosis
GO:0070672	response to interleukin-15
GO:0070669	response to interleukin-2
GO:0070670	response to interleukin-4
GO:0071104	response to interleukin-9
GO:0043029	T cell homeostasis
GO:0042506	tyrosine phosphorylation of Stat5 protein

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005622	intracellular
GO:0016020	membrane

Molecular Function

GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0019903	protein phosphatase binding
GO:0004713	protein tyrosine kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

IPR019749	Band 4.1 domain
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR020685	Tyrosine-protein kinase
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020933	Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR016251	Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR020775	Tyrosine-protein kinase, non-receptor Jak3
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Janus kinase 3

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function