mutL homolog 1 (E. coli)

Synonym

colon cancer, nonpolyposis type 2, AI325952, AI561766, mutL homolog 1 (E. coli), MutL protein homolog 1, DNA mismatch repair protein Mlh1, Mlh1, 1110035C23Rik, AI317206

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:39.90

cerebellum:18.40

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:57.30

spine:47.30

retina:32.10

eye:22.80

artery/aorta:-

vein:-

lymphnode:32.40

peripheral blood:115

spleen:65.80

thymus:69.20

bone marrow:25.60

adipose:-

bone:37.60

skin:79.20

GeneChip

cerebrum:6.59

cerebellum:6.61

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:6.78

spine:6.46

retina:7.66

eye:7.50

artery/aorta:-

vein:7.06

lymphnode:7.63

peripheral blood:-

spleen:7.58

thymus:-

bone marrow:7.76

adipose:7.29

bone:7.50

skin:7.17

CAGE

cerebrum:2.58

cerebellum:-

brain stem:2.39

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:2.55

retina:-

eye:-

artery/aorta:2.53

vein:-

lymphnode:3.44

peripheral blood:-

spleen:2.86

thymus:2.76

bone marrow:-

adipose:-

bone:2.19

skin:2.74

RNA-seq

cerebrum:1.45

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:69

prostate:61.80

ovary:34.50

testis:29.60

heart:111.60

muscle:35.50

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:18.10

lung:70.30

bladder:-

kidney:64.50

pituitary:103.30

thyroid/parathyroid:-

adrenal gland:424.40

pancreas:37.50

breast:62

salivary:-

GeneChip

uterus:7.35

placenta:7.04

prostate:7.64

ovary:7.15

testis:6.67

heart:7.11

muscle:7.14

esophagus:-

stomach:7.04

intestine:7.39

colon:-

liver/hepato:7.51

lung:6.70

bladder:7.23

kidney:7

pituitary:7.33

thyroid/parathyroid:-

adrenal gland:7.10

pancreas:6.55

breast:7.29

salivary:7.79

CAGE

uterus:2.76

placenta:2.53

prostate:2.79

ovary:2.95

testis:1.60

heart:-

muscle:-

esophagus:-

stomach:2.66

intestine:2.86

colon:2.79

liver/hepato:3.04

lung:2.55

bladder:2.66

kidney:-

pituitary:2.93

thyroid/parathyroid:-

adrenal gland:2.59

pancreas:2.97

breast:3.02

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:2.07

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:2.60

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_026810
Gene ID	17350
Unigene ID	Mm.196006
Probe set ID	1417360_at [Mouse430_2]
Ensembl ID	ENSMUSG00000032498

Orthologous Gene

Human[4]	NM_000249, NM_001167617, NM_001167618, NM_001167619
Rat [0]

Chromosomal Region

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0007049	cell cycle
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis
GO:0006281	DNA repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0045190	isotype switching
GO:0007140	male meiosis
GO:0007060	male meiosis chromosome segregation
GO:0007126	meiosis
GO:0045132	meiotic chromosome segregation
GO:0043060	meiotic metaphase I plate congression
GO:0006298	mismatch repair
GO:0045950	negative regulation of mitotic recombination
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0048477	oogenesis
GO:0007131	reciprocal meiotic recombination
GO:0000712	resolution of meiotic recombination intermediates
GO:0006974	response to DNA damage stimulus
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0016447	somatic recombination of immunoglobulin gene segments
GO:0002204	somatic recombination of immunoglobulin genes during immune response
GO:0007283	spermatogenesis
GO:0051257	spindle midzone assembly involved in meiosis
GO:0007129	synapsis

Cellular Component

GO:0005712	chiasma
GO:0005694	chromosome
GO:0000793	condensed chromosome
GO:0000794	condensed nuclear chromosome
GO:0001673	male germ cell nucleus
GO:0032389	MutLalpha complex
GO:0032390	MutLbeta complex
GO:0005634	nucleus
GO:0000795	synaptonemal complex

Molecular Function

GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0032137	guanine/thymine mispair binding
GO:0030983	mismatched DNA binding
GO:0032407	MutSalpha complex binding
GO:0003697	single-stranded DNA binding
GO:0043566	structure-specific DNA binding

mutL homolog 1 (E. coli)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function