mutS homolog 6 (E. coli)

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Synonym

AW550279, DNA mismatch repair protein MSH6, Gtmbp, GTMBP, GTBP, mutS homolog 6 (E. coli), MutS-alpha 160 kDa subunit, AU044881, Msh6, p160, G/T mismatch-binding protein

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:78.10 cerebellum:55.30 brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:- retina:32.10 eye:243.10 artery/aorta:- vein:- lymphnode:64.80 peripheral blood:14.40 spleen:118.50 thymus:128.40 bone marrow:- adipose:- bone:100.20 skin:55.40
GeneChip cerebrum:6.54 cerebellum:7.10 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.62 spine:6.83 retina:7.03 eye:7 artery/aorta:- vein:7.66 lymphnode:8.44 peripheral blood:- spleen:8.32 thymus:- bone marrow:9.36 adipose:6.84 bone:9.02 skin:7.59
CAGE cerebrum:2.67 cerebellum:- brain stem:2.44 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.76 retina:- eye:- artery/aorta:2.40 vein:- lymphnode:2.84 peripheral blood:- spleen:3.50 thymus:4.23 bone marrow:- adipose:- bone:3.35 skin:2.63
RNA-seq cerebrum:4.66 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:69 prostate:- ovary:160.90 testis:110.80 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:9.10        lung:40.20    bladder:- kidney:56.40 pituitary:167.90 thyroid/parathyroid:- adrenal gland:- pancreas:122 breast:55.50 salivary:-
GeneChip uterus:8.42 placenta:6.82 prostate:7.71 ovary:8.51 testis:8.19 heart:6.02 muscle:5.44 esophagus:- stomach:7.07 intestine:7.73 colon:- liver/hepato:6.86 lung:6.98 bladder:7.33 kidney:7.20 pituitary:7.18 thyroid/parathyroid:- adrenal gland:6.56 pancreas:5.63 breast:7.04 salivary:6.43
CAGE uterus:3.14 placenta:2.54 prostate:2.64 ovary:3.14 testis:3.48 heart:- muscle:- esophagus:- stomach:2.44 intestine:2.38 colon:2.64     liver/hepato:2.32    lung:2.70 bladder:2.65 kidney:- pituitary:2.95 thyroid/parathyroid:- adrenal gland:2.39 pancreas:2.56 breast:2.62 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.69 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.06        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_010830
Gene ID 17688
Unigene ID Mm.18210
Probe set ID 1416915_at  [Mouse430_2]
Ensembl ID ENSMUSG00000005370

Orthologous Gene

Human[2]  NM_000179
Rat[2]  NM_000179

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000432  DNA mismatch repair protein MutS, C-terminal

Link to Pubmed  (Pubmed ID)

7604266
8812455
8870641
9354786
9390556
9823302
10349636
10545954
10662804
10706084
10725249
10809667
10922068
11042159
11076861
11217851
11223406
11691815
11809728
12370835
12466851
12477932
12520002
12612914
12904583
14610273
14632208
15166087
15208683
15238604
15238605
15324697
15805259
16141072
16141073
16260499
16552576
16618598
16713580
16728433
17015724
17142234
17615258
18413732
18538799
18799693
19029948
19124772
20362541
20362542
20412781
20567595
20691478
20934970
21267068
21533166
21589869
21731673
21804017
22083510
22289650
22922362
23071719
23603115
23892456
24457600

Gene Ontology  (GO ID)

Biological Process

GO:0006200  ATP catabolic process
GO:0008340  determination of adult lifespan
GO:0008630  DNA damage response, signal transduction resulting in induction of apoptosis
GO:0006281  DNA repair
GO:0045190  isotype switching
GO:0043570  maintenance of DNA repeat elements
GO:0000710  meiotic mismatch repair
GO:0006298  mismatch repair
GO:0045910  negative regulation of DNA recombination
GO:0051096  positive regulation of helicase activity
GO:0007131  reciprocal meiotic recombination
GO:0006974  response to DNA damage stimulus
GO:0009411  response to UV
GO:0016446  somatic hypermutation of immunoglobulin genes
GO:0016447  somatic recombination of immunoglobulin gene segments

Cellular Component

GO:0032301  MutSalpha complex
GO:0000790  nuclear chromatin

Molecular Function

GO:0043531  ADP binding
GO:0005524  ATP binding
GO:0016887  ATPase activity
GO:0003682  chromatin binding
GO:0003684  damaged DNA binding
GO:0003677  DNA binding
GO:0008094  DNA-dependent ATPase activity
GO:0003690  double-stranded DNA binding
GO:0000400  four-way junction DNA binding
GO:0032137  guanine/thymine mispair binding
GO:0000287  magnesium ion binding
GO:0030983  mismatched DNA binding
GO:0032405  MutLalpha complex binding
GO:0000166  nucleotide binding
GO:0032357  oxidized purine DNA binding
GO:0032138  single base insertion or deletion binding
GO:0032142  single guanine insertion binding
GO:0032143  single thymine insertion binding