muscle, skeletal, receptor tyrosine kinase

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Synonym

muscle, skeletal, receptor tyrosine kinase, Muscle-specific kinase receptor, MGC117677, Musk, Mdk4, Nsk1, MDK4, Mlk, Nsk2, Nsk3, MuSK

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:6.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:12.50 skin:-
GeneChip cerebrum:5.50 cerebellum:5.35 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.54 spine:5.41 retina:5.54 eye:5.61 artery/aorta:- vein:5.46 lymphnode:5.23 peripheral blood:- spleen:5.58 thymus:- bone marrow:5.29 adipose:5.45 bone:5.34 skin:5.64
CAGE cerebrum:0.30 cerebellum:- brain stem:0.07 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0.17 retina:- eye:- artery/aorta:0.54 vein:- lymphnode:0 peripheral blood:- spleen:0 thymus:0.82 bone marrow:- adipose:- bone:1.84 skin:2.05
RNA-seq cerebrum:2.43 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:46 testis:- heart:- muscle:35.50 esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:12.90 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.35 placenta:5.69 prostate:5.57 ovary:5.18 testis:5.42 heart:5.51 muscle:6.34 esophagus:- stomach:5.36 intestine:5.36 colon:- liver/hepato:5.40 lung:5.13 bladder:5.15 kidney:5.29 pituitary:5.62 thyroid/parathyroid:- adrenal gland:5.29 pancreas:5.71 breast:5.54 salivary:5.70
CAGE uterus:0 placenta:1.77 prostate:0.84 ovary:0.62 testis:0.45 heart:- muscle:- esophagus:- stomach:1.75 intestine:0.23 colon:1.03     liver/hepato:0    lung:0 bladder:1.08 kidney:- pituitary:1.96 thyroid/parathyroid:- adrenal gland:0.47 pancreas:0 breast:0.22 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.32 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.06        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001037129
Gene ID 18198
Unigene ID Mm.16148
Probe set ID 1450511_at  [Mouse430_2]
Ensembl ID ENSMUSG00000057280

Orthologous Gene

Human[6]  NM_001166280, NM_001166281, NM_005592
Rat [0]  

Chromosomal Region

4B3  [58,298,834  -  58,390,290]

Gene Family (Interpro ID)

IPR020067  Frizzled-like domain
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7546737
7624144
8535092
8653786
8653787
8892231
9136771
9698449
10191100
10320756
10655525
10934257
11114734
11312299
11312300
11323662
11395002
11748247
11829488
11988168
12165471
12403715
12441053
12466851
12477932
12756238
12832540
12885777
14622576
14678832
15062984
15159418
15496425
15737732
15851520
15883645
15964791
16146674
16237673
16337809
16407563
16487930
16510846
16557298
16602821
16675143
16794080
17012237
17119023
17452444
17576800
17640526
17785180
18084289
18165682
18253062
18272689
18367600
18420419
18434415
18718936
18830404
18848351
18957220
19038220
19345204
20463225
20484637
20498043
20603078
20603331
21255125
21267068
21419809
21441923
21750038
22142810
22210232
22328506
22396407
22498925
22939980
23382219
23482493
23621612
23986861
24297891

Gene Ontology  (GO ID)

Biological Process

GO:0030154  cell differentiation
GO:0060291  long-term synaptic potentiation
GO:0007613  memory
GO:0007275  multicellular organismal development
GO:0010629  negative regulation of gene expression
GO:0007528  neuromuscular junction development
GO:0016310  phosphorylation
GO:0010628  positive regulation of gene expression
GO:0043525  positive regulation of neuron apoptosis
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0045887  positive regulation of synaptic growth at neuromuscular junction
GO:0032224  positive regulation of synaptic transmission, cholinergic
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0043113  receptor clustering
GO:0008582  regulation of synaptic growth at neuromuscular junction
GO:0006355  regulation of transcription, DNA-dependent
GO:0051602  response to electrical stimulus
GO:0007165  signal transduction
GO:0071340  skeletal muscle nicotinic acetylcholine receptor clustering

Cellular Component

GO:0030054  cell junction
GO:0042995  cell projection
GO:0009897  external side of plasma membrane
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0031594  neuromuscular junction
GO:0005886  plasma membrane
GO:0045211  postsynaptic membrane
GO:0045202  synapse

Molecular Function

GO:0005524  ATP binding
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding
GO:0004713  protein tyrosine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0004714  transmembrane receptor protein tyrosine kinase activity