6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

 jump to detail

Synonym

PFK-2/FBPase-2 gene B, PFK-2/FBPase-2, 4930568D07Rik, 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme, Pfkfb2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:26 cerebellum:92.10 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:45.60 artery/aorta:- vein:- lymphnode:32.40 peripheral blood:28.80 spleen:13.20 thymus:39.50 bone marrow:- adipose:- bone:- skin:23.80
GeneChip cerebrum:4.68 cerebellum:4.82 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.64 spine:4.72 retina:3.70 eye:3.61 artery/aorta:- vein:4.09 lymphnode:4.19 peripheral blood:- spleen:3.90 thymus:- bone marrow:4.64 adipose:4.44 bone:3.99 skin:4.35
CAGE cerebrum:3.60 cerebellum:- brain stem:3.45 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.57 retina:- eye:- artery/aorta:2.93 vein:- lymphnode:3.29 peripheral blood:- spleen:2.26 thymus:2.46 bone marrow:- adipose:- bone:2.37 skin:3.71
RNA-seq cerebrum:1.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:41.40 prostate:- ovary:- testis:44.30 heart:- muscle:- esophagus:- stomach:130.90 intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:8.10 pituitary:25.80 thyroid/parathyroid:- adrenal gland:- pancreas:37.50 breast:22.90 salivary:-
GeneChip uterus:4.19 placenta:4.37 prostate:4.43 ovary:4.17 testis:7.34 heart:6.68 muscle:4.40 esophagus:- stomach:4.60 intestine:4.55 colon:- liver/hepato:4.26 lung:5.89 bladder:4.66 kidney:4.16 pituitary:4.15 thyroid/parathyroid:- adrenal gland:4.07 pancreas:4.83 breast:4.22 salivary:3.89
CAGE uterus:3.09 placenta:3.00 prostate:4.39 ovary:3.05 testis:3.66 heart:- muscle:- esophagus:- stomach:3.54 intestine:3.75 colon:3.60     liver/hepato:3.13    lung:4.07 bladder:3.41 kidney:- pituitary:3.10 thyroid/parathyroid:- adrenal gland:3.62 pancreas:3.91 breast:3.62 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.19 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.25        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_008825
Gene ID 18640
Unigene ID Mm.249861
Probe set ID 1422090_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000026409

Orthologous Gene

Human[3]  NM_001018053, NM_006212
Rat[3]  NM_001033964, NM_001033965, NM_080477

Chromosomal Region

1E4  [132,585,620  -  132,625,830]

Gene Family (Interpro ID)

IPR016260  Bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphate 2-phosphatase
IPR003094  Fructose-2,6-bisphosphatase

Link to Pubmed  (Pubmed ID)

8814283
9202079
10349636
11042159
11076861
11217851
12466851
12477932
14623077
14681479
15489334
15561968
16141072
16141073
17991424
18039179
20687898
21074528
21565611
21677750
23595884

Gene Ontology  (GO ID)

Biological Process

GO:0006003  fructose 2,6-bisphosphate metabolic process
GO:0006000  fructose metabolic process
GO:0006007  glucose catabolic process
GO:0006096  glycolysis
GO:0006089  lactate metabolic process
GO:0008152  metabolic process
GO:0016310  phosphorylation
GO:0033133  positive regulation of glucokinase activity
GO:0032024  positive regulation of insulin secretion
GO:0006090  pyruvate metabolic process
GO:0009749  response to glucose stimulus

Cellular Component

GO:0005737  cytoplasm

Molecular Function

GO:0003873  6-phosphofructo-2-kinase activity
GO:0005524  ATP binding
GO:0003824  catalytic activity
GO:0004331  fructose-2,6-bisphosphate 2-phosphatase activity
GO:0016787  hydrolase activity
GO:0016301  kinase activity
GO:0019900  kinase binding
GO:0000166  nucleotide binding
GO:0019901  protein kinase binding
GO:0016740  transferase activity