perforin 1 (pore forming protein)

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Synonym

Prf-1, Perforin-1 precursor, perforin 1 (pore forming protein), perforin, Cytolysin, Lymphocyte pore-forming protein, Prf1, Pfp

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:39.50 thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:4.52 cerebellum:4.66 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:4.61 spine:4.73 retina:4.66 eye:4.83 artery/aorta:- vein:4.63 lymphnode:6.69 peripheral blood:- spleen:7.47 thymus:- bone marrow:5.15 adipose:4.88 bone:4.83 skin:5.06
CAGE cerebrum:0 cerebellum:- brain stem:0.07 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0.46 vein:- lymphnode:2.33 peripheral blood:- spleen:1.76 thymus:1.26 bone marrow:- adipose:- bone:0.63 skin:0.97
RNA-seq cerebrum:0.20 cerebellum:0.20 brain stem:0.20 corpus callosum/glia:0.20 pineal gland:0.20 peripheral nerve:0.20 spine:0.20 retina:0.20 eye:0.20 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:87.20 placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.04 placenta:5.81 prostate:4.89 ovary:4.44 testis:4.49 heart:5.09 muscle:4.79 esophagus:- stomach:4.67 intestine:4.88 colon:- liver/hepato:5.52 lung:5.33 bladder:4.75 kidney:4.80 pituitary:4.72 thyroid/parathyroid:- adrenal gland:4.61 pancreas:5.49 breast:4.91 salivary:4.98
CAGE uterus:0.97 placenta:3.63 prostate:0 ovary:0.25 testis:0 heart:- muscle:- esophagus:- stomach:0 intestine:0.42 colon:0.57     liver/hepato:0    lung:2.25 bladder:0.33 kidney:- pituitary:0 thyroid/parathyroid:- adrenal gland:0.64 pancreas:0.84 breast:0.71 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_011073
Gene ID 18646
Unigene ID Mm.240313
Probe set ID 1451862_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000037202

Orthologous Gene

Human[2]  NM_001083116, NM_005041
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR020864  Membrane attack complex component/perforin (MACPF) domain

Link to Pubmed  (Pubmed ID)

1401900
1505959
1577064
1981053
2095003
2303785
2783486
2783549
3190678
3261391
7494105
7518614
7520535
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Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0007623  circadian rhythm
GO:0019835  cytolysis
GO:0002357  defense response to tumor cell
GO:0051607  defense response to virus
GO:0002418  immune response to tumor cell
GO:0051260  protein homooligomerization
GO:0055085  transmembrane transport

Cellular Component

GO:0044194  cytolytic granule
GO:0016023  cytoplasmic membrane-bounded vesicle
GO:0031410  cytoplasmic vesicle
GO:0005768  endosome
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005509  calcium ion binding
GO:0046872  metal ion binding
GO:0022829  wide pore channel activity