purine-nucleoside phosphorylase 1

Synonym

purine-nucleoside phosphorylase, Pnp, Inosine phosphorylase, AL024301, PNP, Purine nucleoside phosphorylase, Np-1, Np-2, AU015798, Np

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:34.70

cerebellum:18.40

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:19.10

spine:-

retina:96.40

eye:60.80

artery/aorta:-

vein:-

lymphnode:32.40

peripheral blood:71.90

spleen:131.70

thymus:29.60

bone marrow:307.70

adipose:-

bone:75.10

skin:15.80

GeneChip

cerebrum:7.21

cerebellum:6.63

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:7.22

spine:7.32

retina:6.73

eye:8.12

artery/aorta:-

vein:10.05

lymphnode:9.67

peripheral blood:-

spleen:9.24

thymus:-

bone marrow:11.73

adipose:9.67

bone:11.32

skin:8.91

CAGE

cerebrum:2.50

cerebellum:-

brain stem:3.19

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:3.19

retina:-

eye:-

artery/aorta:4.62

vein:-

lymphnode:4.05

peripheral blood:-

spleen:5.39

thymus:3.37

bone marrow:-

adipose:-

bone:4.89

skin:3.60

RNA-seq

cerebrum:4.25

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:43.60

placenta:110.50

prostate:154.40

ovary:68.90

testis:73.90

heart:18.60

muscle:-

esophagus:-

stomach:98.20

intestine:73.90

colon:158.60

liver/hepato:54.30

lung:60.30

bladder:-

kidney:56.40

pituitary:12.90

thyroid/parathyroid:-

adrenal gland:-

pancreas:46.90

breast:49

salivary:54

GeneChip

uterus:9.68

placenta:9.80

prostate:7.82

ovary:8.87

testis:7.55

heart:7.90

muscle:7.68

esophagus:-

stomach:9.23

intestine:10.70

colon:-

liver/hepato:10.38

lung:9.65

bladder:8.29

kidney:9.95

pituitary:8.62

thyroid/parathyroid:-

adrenal gland:8.33

pancreas:6.40

breast:8.44

salivary:6.48

CAGE

uterus:4.71

placenta:4.43

prostate:3.31

ovary:3.64

testis:2.25

heart:-

muscle:-

esophagus:-

stomach:3.89

intestine:5.59

colon:5.49

liver/hepato:4.67

lung:4.31

bladder:3.48

kidney:-

pituitary:3.96

thyroid/parathyroid:-

adrenal gland:3.60

pancreas:2.83

breast:3.68

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:4.29

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:19.77

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_013632
Gene ID	18950
Unigene ID	Mm.17932
Probe set ID	1453299_a_at [Mouse430_2]
Ensembl ID	ENSMUSG00000021871

Orthologous Gene

Human[2]	NM_000270
Rat[1]	NM_001106031

Chromosomal Region

Gene Family (Interpro ID)

IPR011268	Inosine guanosine/xanthosine phosphorylase
IPR000845	Nucleoside phosphorylase
IPR011270	Purine nucleoside phosphorylase I, inosine/guanosine-specific
IPR001369	Purine phosphorylase, family 2

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

GO:0008637	apoptotic mitochondrial changes
GO:0006161	deoxyguanosine catabolic process
GO:0006149	deoxyinosine catabolic process
GO:0046070	dGTP metabolic process
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis
GO:0006183	GTP biosynthetic process
GO:0046115	guanosine catabolic process
GO:0006148	inosine catabolic process
GO:0070233	negative regulation of T cell apoptosis
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0009116	nucleoside metabolic process
GO:0046638	positive regulation of alpha-beta T cell differentiation
GO:0045579	positive regulation of B cell differentiation
GO:0045739	positive regulation of DNA repair
GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0042102	positive regulation of T cell proliferation
GO:0042278	purine nucleoside metabolic process
GO:0010332	response to gamma radiation
GO:0034418	urate biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005829	cytosol
GO:0005576	extracellular region
GO:0005622	intracellular
GO:0005634	nucleus

Molecular Function

GO:0003824	catalytic activity
GO:0008144	drug binding
GO:0001882	nucleoside binding
GO:0042301	phosphate binding
GO:0002060	purine binding
GO:0004731	purine-nucleoside phosphorylase activity
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0016763	transferase activity, transferring pentosyl groups

purine-nucleoside phosphorylase 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function