replication factor C (activator 1) 1

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Synonym

Differentiation-specific element-binding protein, RFC140, ISRE-binding protein, 140kDa, Replication factor C large subunit, RF-C 140 kDa subunit, Activator 1 large subunit, Ibf-1, A1-P145, Activator 1 140 kDa subunit, A1 140 kDa subunit, Recc1, Replication factor C subunit 1, MGC96526, Alp145, replication factor C 1, Rfc1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:86.80 cerebellum:18.40 brain stem:95.30 corpus callosum/glia:- pineal gland:- peripheral nerve:19.10 spine:- retina:- eye:250.70 artery/aorta:- vein:- lymphnode:- peripheral blood:57.50 spleen:- thymus:39.50 bone marrow:- adipose:- bone:100.20 skin:23.80
GeneChip cerebrum:6.82 cerebellum:6.53 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:7.82 spine:6.56 retina:7.32 eye:7.35 artery/aorta:- vein:7.91 lymphnode:8.58 peripheral blood:- spleen:7.81 thymus:- bone marrow:8.98 adipose:7.35 bone:8.44 skin:7.67
CAGE cerebrum:3.47 cerebellum:- brain stem:3.42 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.52 retina:- eye:- artery/aorta:3.92 vein:- lymphnode:4.66 peripheral blood:- spleen:4.11 thymus:4.04 bone marrow:- adipose:- bone:3.75 skin:3.96
RNA-seq cerebrum:1.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:13.80 prostate:61.80 ovary:46 testis:118.20 heart:18.60 muscle:35.50 esophagus:- stomach:- intestine:- colon:35.20     liver/hepato:-        lung:60.30    bladder:- kidney:- pituitary:25.80 thyroid/parathyroid:- adrenal gland:- pancreas:46.90 breast:78.40 salivary:54
GeneChip uterus:6.78 placenta:6.93 prostate:6.61 ovary:7.83 testis:8.31 heart:7.41 muscle:7.54 esophagus:- stomach:5.94 intestine:7.03 colon:- liver/hepato:6.64 lung:7.36 bladder:7.48 kidney:6.77 pituitary:7.69 thyroid/parathyroid:- adrenal gland:8.07 pancreas:7.19 breast:7.38 salivary:7.53
CAGE uterus:3.67 placenta:3.36 prostate:3.53 ovary:3.93 testis:5.02 heart:- muscle:- esophagus:- stomach:2.95 intestine:3.29 colon:3.25     liver/hepato:3.02    lung:3.76 bladder:3.78 kidney:- pituitary:3.67 thyroid/parathyroid:- adrenal gland:3.60 pancreas:3.27 breast:3.77 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.91 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.38        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_011258
Gene ID 19687
Unigene ID Mm.148877
Probe set ID 1451920_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000029191

Orthologous Gene

Human[2]  NM_001204747, NM_002913
Rat[2]  NM_053547, NM_002913

Chromosomal Region

-

Gene Family (Interpro ID)

IPR003593  ATPase, AAA+ type, core

Link to Pubmed  (Pubmed ID)

1691767
7579892
7579896
7659092
7665082
7719032
8114700
8265586
8589683
9050988
9826522
10349636
10479478
10922068
11034547
11042159
11076861
11217851
11463338
11555636
12466851
12477932
12520002
14610273
14991595
15226823
15618518
16141072
16141073
17967808
18287559
18799693
20059953
21425081
22083510
23649778

Gene Ontology  (GO ID)

Biological Process

GO:0006260  DNA replication
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006355  regulation of transcription, DNA-dependent
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005737  cytoplasm
GO:0005663  DNA replication factor C complex
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0043234  protein complex

Molecular Function

GO:0005524  ATP binding
GO:0003677  DNA binding
GO:0003689  DNA clamp loader activity
GO:0003690  double-stranded DNA binding
GO:0017111  nucleoside-triphosphatase activity
GO:0000166  nucleotide binding
GO:0019904  protein domain specific binding
GO:0043565  sequence-specific DNA binding