myeloid/lymphoid or mixed-lineage leukemia 1

Synonym

All1, HRX, KIAA4050, myeloid/lymphoid or mixed-lineage leukemia 1, trithorax Drosophila, ALL-1, Zinc finger protein HRX, Cxxc7, Hrx, Mll, 6430520K01, HTRX1, Mll1, mKIAA4050

normal 40 tissues
developmental tissues and primary cells（FANTOM5 CAGE）

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:5.28

cerebellum:6.86

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:5.09

spine:5.29

retina:5.24

eye:6.08

artery/aorta:-

vein:4.91

lymphnode:5.15

peripheral blood:-

spleen:5.30

thymus:-

bone marrow:5.09

adipose:5.57

bone:5.08

skin:5.07

CAGE

cerebrum:4.31

cerebellum:-

brain stem:4.00

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:4.02

retina:-

eye:-

artery/aorta:3.61

vein:-

lymphnode:4.27

peripheral blood:-

spleen:3.88

thymus:4.27

bone marrow:-

adipose:-

bone:3.77

skin:4.02

RNA-seq

cerebrum:4.51

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:4.92

placenta:5.45

prostate:5.02

ovary:4.79

testis:5.57

heart:5.66

muscle:5.96

esophagus:-

stomach:5.32

intestine:6.16

colon:-

liver/hepato:12.56

lung:7.68

bladder:5.52

kidney:12.89

pituitary:5.45

thyroid/parathyroid:-

adrenal gland:6.95

pancreas:6

breast:5.32

salivary:4.87

CAGE

uterus:3.78

placenta:3.39

prostate:3.67

ovary:3.98

testis:1.71

heart:-

muscle:-

esophagus:-

stomach:2.73

intestine:3.22

colon:3.19

liver/hepato:2.70

lung:4.00

bladder:3.92

kidney:-

pituitary:4.62

thyroid/parathyroid:-

adrenal gland:3.82

pancreas:4.06

breast:3.55

salivary:-

RNA-seq

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:1.63

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:2.61

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

IDs

Refseq ID	NM_001081049
Gene ID	214162
Unigene ID	-
Probe set ID	1418696_at [Mouse430_2]
Ensembl ID	ENSMUSG00000002028

Orthologous Gene

Human[5]	NM_001197104, NM_005933
Rat[5]	NM_001197104, NM_005933

Chromosomal Region

Gene Family (Interpro ID)

IPR003889	FY-rich, C-terminal
IPR018516	FY-rich, C-terminal subgroup
IPR003888	FY-rich, N-terminal
IPR018518	FY-rich, N-terminal subgroup
IPR019787	Zinc finger, PHD-finger
IPR001965	Zinc finger, PHD-type

Gene Ontology (GO ID)

Biological Process

GO:0009952	anterior/posterior pattern formation
GO:0016568	chromatin modification
GO:0006306	DNA methylation
GO:0035162	embryonic hemopoiesis
GO:0051568	histone H3-K4 methylation
GO:0043984	histone H4-K16 acetylation
GO:0032259	methylation
GO:0008285	negative regulation of cell proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0032411	positive regulation of transporter activity
GO:0006461	protein complex assembly
GO:0051569	regulation of histone H3-K4 methylation
GO:0006355	regulation of transcription, DNA-dependent
GO:0006351	transcription, DNA-dependent

Cellular Component

GO:0035097	histone methyltransferase complex
GO:0071339	MLL1 complex
GO:0005634	nucleus

Molecular Function

GO:0003682	chromatin binding
GO:0003677	DNA binding
GO:0044212	DNA regulatory region binding
GO:0070577	histone acetyl-lysine binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0018024	histone-lysine N-methyltransferase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0008168	methyltransferase activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0016740	transferase activity
GO:0045322	unmethylated CpG binding
GO:0008270	zinc ion binding

myeloid/lymphoid or mixed-lineage leukemia 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function