arrestin, beta 2

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Synonym

beta-arrestin-2, beta arr2, AI326910, Arrestin beta 2, arrestin, beta 2, AW122872, Beta-arrestin-2, Arrb2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:46.90 cerebellum:- brain stem:63.60 corpus callosum/glia:- pineal gland:- peripheral nerve:114.70 spine:47.30 retina:32.10 eye:15.20 artery/aorta:- vein:- lymphnode:356.40 peripheral blood:- spleen:79 thymus:29.60 bone marrow:102.60 adipose:- bone:187.90 skin:15.80
GeneChip cerebrum:8.29 cerebellum:8.44 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:8.63 spine:8.74 retina:6.28 eye:6.04 artery/aorta:- vein:7.42 lymphnode:10.48 peripheral blood:- spleen:10.44 thymus:- bone marrow:11.46 adipose:7.67 bone:10.64 skin:6.65
CAGE cerebrum:3.57 cerebellum:- brain stem:3.28 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.54 retina:- eye:- artery/aorta:3.16 vein:- lymphnode:4.86 peripheral blood:- spleen:4.13 thymus:4.04 bone marrow:- adipose:- bone:4.99 skin:3.33
RNA-seq cerebrum:7.49 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:13.80 prostate:61.80 ovary:- testis:7.40 heart:18.60 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:18.10        lung:30.10    bladder:132.40 kidney:16.10 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:55.50 salivary:108
GeneChip uterus:8.80 placenta:7.02 prostate:7.96 ovary:7.91 testis:7.17 heart:7.21 muscle:7.01 esophagus:- stomach:7.49 intestine:7.42 colon:- liver/hepato:8.12 lung:7.97 bladder:7.07 kidney:7 pituitary:7.32 thyroid/parathyroid:- adrenal gland:7.56 pancreas:8.39 breast:7.61 salivary:7.47
CAGE uterus:3.02 placenta:1.95 prostate:3.13 ovary:2.89 testis:1.89 heart:- muscle:- esophagus:- stomach:3.42 intestine:2.33 colon:2.95     liver/hepato:3.13    lung:3.61 bladder:2.79 kidney:- pituitary:2.53 thyroid/parathyroid:- adrenal gland:3.17 pancreas:3.53 breast:2.73 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.99 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.59        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_145429
Gene ID 216869
Unigene ID Mm.203747
Probe set ID 1451987_at  [Mouse430_2]
Ensembl ID ENSMUSG00000060216

Orthologous Gene

Human[2]  NM_004313, NM_199004
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1458825
7613043
7932878
8889548
9333241
10349636
10508404
10549660
10617462
11042159
11076861
11130073
11171997
11217851
11588219
12032308
12167659
12393857
12451149
12466851
12477932
12925697
12944399
12947104
12958365
14610273
14614085
14744875
15218143
15364949
15489334
15637145
15705780
15718284
15765183
15782199
15788776
16027114
16051150
16141072
16141073
16210646
16263766
16319069
16325578
16378096
16809338
16980301
17060617
17060906
17418896
17426148
17442737
17494695
17525124
17540773
17594911
17618287
17680774
18180038
18191226
18194271
18195357
18367649
18390755
18497258
18519945
18612077
18622177
18691971
18775329
18802075
19008961
19047375
19113915
19122674
19126537
19129399
19224602
19279269
19309759
19349687
19429870
19477151
19477204
19560570
19783052
19794961
19805483
19896992
19955404
20060823
20207744
20368153
20421423
20460106
20465566
20497256
20530803
20589830
20713067
20813258
20886089
20926677
21106537
21139074
21183229
21228603
21267068
21321125
21369867
21389118
21411739
21543334
21630325
21677750
21700709
21757712
21821916
21824517
21855149
21857681
21891823
22025682
22025698
22034973
22174878
22308427
22315403
22318609
22491351
22523395
22581458
22689562
22699970
22773819
22886417
22888001
22952227
23012429
23166351
23188793
23202293
23235155
23449980
23524589
23541635
23557604
23589623
23660189
23689346
23753627
23775075
23809162
23839051
23859136
23861891
23960234
24056371
24317793

Gene Ontology  (GO ID)

Biological Process

GO:0007628  adult walking behavior
GO:0060326  cell chemotaxis
GO:0002032  desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0050965  detection of temperature stimulus involved in sensory perception of pain
GO:0006309  DNA fragmentation involved in apoptosis
GO:0006897  endocytosis
GO:0042699  follicle-stimulating hormone signaling pathway
GO:0002031  G-protein coupled receptor internalization
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0034260  negative regulation of GTPase activity
GO:0032691  negative regulation of interleukin-1 beta production
GO:0032695  negative regulation of interleukin-12 production
GO:0032715  negative regulation of interleukin-6 production
GO:0045953  negative regulation of natural killer cell mediated cytotoxicity
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0031397  negative regulation of protein ubiquitination
GO:0009968  negative regulation of signal transduction
GO:0034392  negative regulation of smooth muscle cell apoptosis
GO:0034122  negative regulation of toll-like receptor signaling pathway
GO:0032720  negative regulation of tumor necrosis factor production
GO:0043065  positive regulation of apoptosis
GO:0051928  positive regulation of calcium ion transport
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0031398  positive regulation of protein ubiquitination
GO:0002092  positive regulation of receptor internalization
GO:0090200  positive regulation of release of cytochrome c from mitochondria
GO:0032226  positive regulation of synaptic transmission, dopaminergic
GO:0043161  proteasomal ubiquitin-dependent protein catabolic process
GO:0015031  protein transport
GO:0016567  protein ubiquitination
GO:0031623  receptor internalization
GO:0060765  regulation of androgen receptor signaling pathway
GO:0008277  regulation of G-protein coupled receptor protein signaling pathway
GO:0001932  regulation of protein amino acid phosphorylation
GO:0007165  signal transduction
GO:0006366  transcription from RNA polymerase II promoter
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0006810  transport

Cellular Component

GO:0016323  basolateral plasma membrane
GO:0005905  coated pit
GO:0005737  cytoplasm
GO:0031410  cytoplasmic vesicle
GO:0043197  dendritic spine
GO:0005622  intracellular
GO:0016020  membrane
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane

Molecular Function

GO:0031691  alpha-1A adrenergic receptor binding
GO:0031692  alpha-1B adrenergic receptor binding
GO:0031701  angiotensin receptor binding
GO:0031748  D1 dopamine receptor binding
GO:0031762  follicle stimulating hormone receptor binding
GO:0001664  G-protein-coupled receptor binding
GO:0051019  mitogen-activated protein kinase binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0032947  protein complex scaffold
GO:0019904  protein domain specific binding
GO:0043422  protein kinase B binding
GO:0005102  receptor binding
GO:0031702  type 1 angiotensin receptor binding
GO:0031826  type 2A serotonin receptor binding
GO:0031625  ubiquitin protein ligase binding