transforming growth factor, beta receptor III

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Synonym

TGF-beta receptor type III precursor, Betaglycan, AU015626, AW215636, transforming growth factor, beta receptor III, 1110036H20Rik, Tgfbr3, betaglycan, TGFR-3, TBRIII, Transforming growth factor beta receptor III

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:38.20 cerebellum:36.80 brain stem:63.60 corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:- retina:- eye:38 artery/aorta:84.40 vein:- lymphnode:108 peripheral blood:43.10 spleen:26.30 thymus:69.20 bone marrow:12.80 adipose:212.70 bone:50.10 skin:7.90
GeneChip cerebrum:5.52 cerebellum:6.14 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.95 spine:5.81 retina:5.35 eye:5.55 artery/aorta:- vein:6.96 lymphnode:7.27 peripheral blood:- spleen:6.34 thymus:- bone marrow:5.81 adipose:7.37 bone:5.71 skin:5.79
CAGE cerebrum:3.28 cerebellum:- brain stem:2.60 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.86 retina:- eye:- artery/aorta:4.74 vein:- lymphnode:4.37 peripheral blood:- spleen:3.18 thymus:3.62 bone marrow:- adipose:- bone:3.38 skin:4.59
RNA-seq cerebrum:1.27 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:218.10 placenta:82.80 prostate:- ovary:23 testis:51.70 heart:74.40 muscle:- esophagus:- stomach:163.60 intestine:73.90 colon:35.20     liver/hepato:9.10        lung:120.50    bladder:397.10 kidney:24.20 pituitary:25.80 thyroid/parathyroid:- adrenal gland:- pancreas:93.80 breast:55.50 salivary:-
GeneChip uterus:6.80 placenta:8.28 prostate:6.36 ovary:6.46 testis:6 heart:7.04 muscle:5.94 esophagus:- stomach:6.22 intestine:5.72 colon:- liver/hepato:5.44 lung:6.71 bladder:7.23 kidney:6.07 pituitary:6.71 thyroid/parathyroid:- adrenal gland:6.53 pancreas:6.01 breast:6.90 salivary:5.46
CAGE uterus:4.43 placenta:4.83 prostate:4.38 ovary:4.54 testis:2.85 heart:- muscle:- esophagus:- stomach:3.13 intestine:2.62 colon:2.71     liver/hepato:3.01    lung:4.37 bladder:4.28 kidney:- pituitary:4.35 thyroid/parathyroid:- adrenal gland:5.18 pancreas:3.49 breast:4.30 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.06 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.06        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_011578
Gene ID 21814
Unigene ID Mm.200775
Probe set ID 1425620_at  [Mouse430_2]
Ensembl ID ENSMUSG00000029287

Orthologous Gene

Human[1]  NM_001195683, NM_001195684, NM_003243
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001507  Endoglin/CD105 antigen
IPR017976  Endoglin/CD105 antigen subgroup

Link to Pubmed  (Pubmed ID)

7813789
8268187
8883836
9659379
9921650
10349636
10725249
10922068
10949049
11042159
11076861
11217851
11546783
12070302
12399463
12466851
12477932
12773577
14610273
14701881
14764882
14996829
15342483
15459394
15489334
15640362
16141072
16141073
16602821
16978288
17160136
17168649
17244351
17295310
17704211
17823118
18095342
18236212
18287559
18340042
19524135
19539053
19696014
19726563
20299672
20967564
21267068
21297076
21402931
21533152
21731673
21792916
21871877
22237159
22560297
22952931
22960625
23303681
23562608
23826237
23925295
24161934
24347165

Gene Ontology  (GO ID)

Biological Process

GO:0001824  blastocyst development
GO:0001568  blood vessel development
GO:0030509  BMP signaling pathway
GO:0060317  cardiac epithelial to mesenchymal transition
GO:0060038  cardiac muscle cell proliferation
GO:0016049  cell growth
GO:0060976  coronary vasculature development
GO:0060977  coronary vasculature morphogenesis
GO:0060318  definitive erythrocyte differentiation
GO:0060216  definitive hemopoiesis
GO:0009790  embryonic development
GO:0003347  epicardial cell to mesenchymal cell transition
GO:0001837  epithelial to mesenchymal transition
GO:0060347  heart trabecula formation
GO:0006955  immune response
GO:0001701  in utero embryonic development
GO:0001889  liver development
GO:0051271  negative regulation of cellular component movement
GO:0010633  negative regulation of epithelial cell migration
GO:0050680  negative regulation of epithelial cell proliferation
GO:0010719  negative regulation of epithelial to mesenchymal transition
GO:0030512  negative regulation of transforming growth factor beta receptor signaling pathway
GO:0060021  palate development
GO:0060389  pathway-restricted SMAD protein phosphorylation
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0006468  protein amino acid phosphorylation
GO:0006461  protein complex assembly
GO:0007243  protein kinase cascade
GO:0050880  regulation of blood vessel size
GO:0043393  regulation of protein binding
GO:0032354  response to follicle-stimulating hormone stimulus
GO:0034699  response to luteinizing hormone stimulus
GO:0034695  response to prostaglandin E stimulus
GO:0007181  transforming growth factor beta receptor complex assembly
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0060979  vasculogenesis involved in coronary vascular morphogenesis
GO:0055010  ventricular cardiac muscle tissue morphogenesis

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005783  endoplasmic reticulum
GO:0009897  external side of plasma membrane
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0034673  inhibin-betaglycan-ActRII complex
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0005886  plasma membrane
GO:0005578  proteinaceous extracellular matrix

Molecular Function

GO:0048185  activin binding
GO:0015026  coreceptor activity
GO:0017134  fibroblast growth factor binding
GO:0005539  glycosaminoglycan binding
GO:0008201  heparin binding
GO:0030165  PDZ domain binding
GO:0005515  protein binding
GO:0046332  SMAD binding
GO:0050431  transforming growth factor beta binding
GO:0005024  transforming growth factor beta receptor activity
GO:0070123  transforming growth factor beta receptor activity, type III
GO:0005160  transforming growth factor beta receptor binding
GO:0005114  type II transforming growth factor beta receptor binding