TYRO3 protein tyrosine kinase 3

 jump to detail

Synonym

Brt, Sky, Tyro3, Etk2/tyro3, Tyrosine-protein kinase RSE, TK19-2, Tyrosine-protein kinase DTK, TYRO3 protein tyrosine kinase 3, Rse, Tyrosine-protein kinase receptor TYRO3 precursor, Dtk, Tif, Etk-2, AI323366

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:8.52 cerebellum:8.78 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.19 spine:8 retina:5.66 eye:4.53 artery/aorta:- vein:5.06 lymphnode:3.59 peripheral blood:- spleen:3.84 thymus:- bone marrow:3.39 adipose:3.99 bone:3.45 skin:6.11
CAGE cerebrum:3.60 cerebellum:- brain stem:3.21 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.25 retina:- eye:- artery/aorta:0.14 vein:- lymphnode:0.23 peripheral blood:- spleen:0.41 thymus:0.82 bone marrow:- adipose:- bone:0 skin:2.05
RNA-seq cerebrum:21.23 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:5.68 placenta:5.30 prostate:7.90 ovary:6.26 testis:7.19 heart:3.86 muscle:3.79 esophagus:- stomach:6.52 intestine:4.76 colon:- liver/hepato:3.88 lung:5.22 bladder:7.07 kidney:3.90 pituitary:3.93 thyroid/parathyroid:- adrenal gland:4.50 pancreas:5.80 breast:5.15 salivary:5.50
CAGE uterus:1.81 placenta:2.20 prostate:1.46 ovary:2.13 testis:2.36 heart:- muscle:- esophagus:- stomach:2.36 intestine:1.22 colon:1.34     liver/hepato:0    lung:1.76 bladder:2.69 kidney:- pituitary:1.11 thyroid/parathyroid:- adrenal gland:0.64 pancreas:2.03 breast:2.97 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:0.79 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.46        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_019392
Gene ID 22174
Unigene ID -
Probe set ID 1425248_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000027298

Orthologous Gene

Human[2]  NM_006293
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

2025425
2466296
3291115
7511603
7542761
7723626
7784069
7857657
7867073
7893599
7896835
8058320
8108111
8108112
8262388
8346215
8661736
8808274
8889809
8954722
9070938
9362459
9670959
9846490
10227296
10349636
10922068
11042159
11076861
11114734
11217851
11452127
11529277
12466851
12477932
12904583
14610273
14695357
15650770
15733062
15782199
16141072
16141073
16365397
16602821
16723520
16751775
16901715
17442946
17488688
18083102
18159085
18188450
18393392
18787040
18799693
19602523
19625016
19729839
19805117
20348395
20363878
20483720
20546121
20692344
21084607
21192804
21267068
21467176
21539887
22043818
22701746
23071254
23259948
23632195
23799121
23840307
24244024

Gene Ontology  (GO ID)

Biological Process

GO:0043277  apoptotic cell clearance
GO:0007155  cell adhesion
GO:0021885  forebrain cell migration
GO:0001779  natural killer cell differentiation
GO:0050728  negative regulation of inflammatory response
GO:0045824  negative regulation of innate immune response
GO:0051250  negative regulation of lymphocyte activation
GO:0043524  negative regulation of neuron apoptosis
GO:0034122  negative regulation of toll-like receptor signaling pathway
GO:0070050  neuron homeostasis
GO:0042698  ovulation cycle
GO:0016310  phosphorylation
GO:0030168  platelet activation
GO:0070527  platelet aggregation
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0043491  protein kinase B signaling cascade
GO:0032940  secretion by cell
GO:0007283  spermatogenesis
GO:0034446  substrate adhesion-dependent cell spreading
GO:0060068  vagina development

Cellular Component

GO:0005789  endoplasmic reticulum membrane
GO:0016021  integral to membrane
GO:0016020  membrane
GO:0005635  nuclear envelope
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0043548  phosphoinositide 3-kinase binding
GO:0046982  protein heterodimerization activity
GO:0004672  protein kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0004714  transmembrane receptor protein tyrosine kinase activity