Werner syndrome homolog (human)

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Synonym

Wrn, AI846146, Werner syndrome ATP-dependent helicase homolog, Werner syndrome homolog (human)

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:12.20 cerebellum:- brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:57.30 spine:- retina:- eye:38 artery/aorta:- vein:- lymphnode:64.80 peripheral blood:28.80 spleen:39.50 thymus:79 bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.38 cerebellum:5.09 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:5.68 spine:5.43 retina:4.92 eye:5.31 artery/aorta:- vein:6.51 lymphnode:7.16 peripheral blood:- spleen:6.93 thymus:- bone marrow:8.61 adipose:6.07 bone:8.10 skin:5.92
CAGE cerebrum:2.22 cerebellum:- brain stem:2.31 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.42 retina:- eye:- artery/aorta:3.29 vein:- lymphnode:4.22 peripheral blood:- spleen:4.07 thymus:3.90 bone marrow:- adipose:- bone:4.21 skin:3.15
RNA-seq cerebrum:1.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:27.60 prostate:92.60 ovary:23 testis:36.90 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:9.10        lung:40.20    bladder:- kidney:- pituitary:51.70 thyroid/parathyroid:- adrenal gland:- pancreas:37.50 breast:19.60 salivary:-
GeneChip uterus:5.98 placenta:6.62 prostate:5.92 ovary:6.07 testis:7.82 heart:5.12 muscle:4.81 esophagus:- stomach:5.89 intestine:6.45 colon:- liver/hepato:5.83 lung:6.05 bladder:6.02 kidney:5.99 pituitary:5.98 thyroid/parathyroid:- adrenal gland:5.89 pancreas:6.21 breast:5.92 salivary:5.40
CAGE uterus:2.95 placenta:2.94 prostate:3.02 ovary:3.24 testis:2.51 heart:- muscle:- esophagus:- stomach:1.75 intestine:2.19 colon:3.10     liver/hepato:2.90    lung:3.44 bladder:3.08 kidney:- pituitary:3.00 thyroid/parathyroid:- adrenal gland:3.05 pancreas:2.90 breast:2.70 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.32 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.70        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_001122822
Gene ID 22427
Unigene ID Mm.228805
Probe set ID 1450163_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000031583

Orthologous Gene

Human[1]  NM_000553
Rat[1]  NM_000553

Chromosomal Region

8A4  [34,344,856  -  34,495,999]

Gene Family (Interpro ID)

IPR002562  3'-5' exonuclease
IPR014001  DEAD-like helicase, N-terminal
IPR004589  DNA helicase, ATP-dependent, RecQ type
IPR014021  Helicase, superfamily 1/2, ATP-binding domain
IPR012337  Polynucleotidyl transferase, ribonuclease H fold

Link to Pubmed  (Pubmed ID)

8602509
8889548
9143515
9618508
9681877
9789047
10349636
10757074
10757812
10782115
10806190
10871373
10922068
11042159
11076861
11087671
11217851
11280729
11301316
11420665
11756244
11863428
12242664
12466851
12477932
12707040
12803543
12944467
14595844
14610273
15235603
15367665
15642393
15743673
16141072
16141073
16195394
16264192
16330174
16769258
16785251
17229737
18295300
18588880
18799693
19896421
20708636
21123451
21267068
21464516
22301954
22753033

Gene Ontology  (GO ID)

Biological Process

GO:0006200  ATP catabolic process
GO:0006284  base-excision repair
GO:0007569  cell aging
GO:0044237  cellular metabolic process
GO:0071480  cellular response to gamma radiation
GO:0009267  cellular response to starvation
GO:0032508  DNA duplex unwinding
GO:0006259  DNA metabolic process
GO:0006310  DNA recombination
GO:0006281  DNA repair
GO:0006260  DNA replication
GO:0000731  DNA synthesis during DNA repair
GO:0006302  double-strand break repair
GO:0008152  metabolic process
GO:0010259  multicellular organismal aging
GO:0006139  nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0032066  nucleolus to nucleoplasm transport
GO:0051345  positive regulation of hydrolase activity
GO:0042981  regulation of apoptosis
GO:0040009  regulation of growth rate
GO:0031297  replication fork processing
GO:0001302  replicative cell aging
GO:0006974  response to DNA damage stimulus
GO:0006979  response to oxidative stress
GO:0010225  response to UV-C
GO:0000723  telomere maintenance

Cellular Component

GO:0005813  centrosome
GO:0005622  intracellular
GO:0032389  MutLalpha complex
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0043138  3'-5' DNA helicase activity
GO:0008408  3'-5' exonuclease activity
GO:0005524  ATP binding
GO:0043140  ATP-dependent 3'-5' DNA helicase activity
GO:0004003  ATP-dependent DNA helicase activity
GO:0008026  ATP-dependent helicase activity
GO:0016887  ATPase activity
GO:0000405  bubble DNA binding
GO:0003824  catalytic activity
GO:0003677  DNA binding
GO:0003678  DNA helicase activity
GO:0004527  exonuclease activity
GO:0009378  four-way junction helicase activity
GO:0051880  G-quadruplex DNA binding
GO:0004386  helicase activity
GO:0016787  hydrolase activity
GO:0000287  magnesium ion binding
GO:0030145  manganese ion binding
GO:0046872  metal ion binding
GO:0004518  nuclease activity
GO:0003676  nucleic acid binding
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0042803  protein homodimerization activity
GO:0000403  Y-form DNA binding