mitogen-activated protein kinase kinase 5

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Synonym

MAP kinase kinase 5, Mek5, Prkmk5, Map2k5, MEK5, MAPK/ERK kinase 5, Mapkk5, Mkk5, MAPKK 5, AI324775, mitogen activated protein kinase kinase 5, AI428457

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:27.80 cerebellum:110.50 brain stem:31.80 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:94.60 retina:64.30 eye:38 artery/aorta:84.40 vein:- lymphnode:43.20 peripheral blood:28.80 spleen:52.70 thymus:98.80 bone marrow:76.90 adipose:212.70 bone:50.10 skin:15.80
GeneChip cerebrum:8.20 cerebellum:8.10 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:8.36 spine:8.39 retina:8.05 eye:7.50 artery/aorta:- vein:7.29 lymphnode:8.03 peripheral blood:- spleen:8.20 thymus:- bone marrow:7.49 adipose:8.42 bone:7.54 skin:7.38
CAGE cerebrum:3.97 cerebellum:- brain stem:3.74 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.77 retina:- eye:- artery/aorta:3.95 vein:- lymphnode:4.06 peripheral blood:- spleen:3.37 thymus:4.41 bone marrow:- adipose:- bone:3.44 skin:4.00
RNA-seq cerebrum:6.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:13.80 prostate:- ovary:11.50 testis:22.20 heart:37.20 muscle:- esophagus:- stomach:65.50 intestine:- colon:17.60     liver/hepato:18.10        lung:50.20    bladder:- kidney:8.10 pituitary:12.90 thyroid/parathyroid:- adrenal gland:- pancreas:- breast:62 salivary:108
GeneChip uterus:8.21 placenta:8.42 prostate:8.04 ovary:8.30 testis:8.97 heart:8.04 muscle:8.80 esophagus:- stomach:7.60 intestine:7.54 colon:- liver/hepato:8.39 lung:7.94 bladder:7.55 kidney:8.36 pituitary:8.12 thyroid/parathyroid:- adrenal gland:7.85 pancreas:6.64 breast:7.85 salivary:7.02
CAGE uterus:3.52 placenta:3.68 prostate:3.15 ovary:3.75 testis:4.24 heart:- muscle:- esophagus:- stomach:3.09 intestine:3.35 colon:3.23     liver/hepato:3.74    lung:3.79 bladder:3.54 kidney:- pituitary:3.68 thyroid/parathyroid:- adrenal gland:3.43 pancreas:3.36 breast:3.45 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:3.59 esophagus:- stomach:- intestine:- colon:-     liver/hepato:3.88        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_011840
Gene ID 23938
Unigene ID Mm.325746
Probe set ID 1417854_at  [Mouse430_2]
Ensembl ID ENSMUSG00000058444

Orthologous Gene

Human[6]  NM_001206804, NM_002757, NM_145160
Rat [0]  

Chromosomal Region

-

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

10349636
10473620
11042159
11073940
11076861
11217851
11387209
12466851
12477932
12520002
12813044
12912994
14610273
14675480
15102471
15305288
15489334
15509711
15601854
15782199
16141072
16141073
16260599
16415348
16478989
16702235
16710360
16919269
17272811
17452462
18287559
18467627
18548009
19605361
19654213
21267068
21677750
22442076
23022299

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0070375  BMK cascade
GO:0071363  cellular response to growth factor stimulus
GO:0007507  heart development
GO:0000165  MAPKKK cascade
GO:0043154  negative regulation of caspase activity
GO:0090051  negative regulation of cell migration involved in sprouting angiogenesis
GO:0034115  negative regulation of heterotypic cell-cell adhesion
GO:0045415  negative regulation of interleukin-8 biosynthetic process
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0060761  negative regulation of response to cytokine stimulus
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0016310  phosphorylation
GO:0030307  positive regulation of cell growth
GO:0050679  positive regulation of epithelial cell proliferation
GO:0051247  positive regulation of protein metabolic process
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006468  protein amino acid phosphorylation

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005634  nucleus
GO:0005819  spindle

Molecular Function

GO:0005524  ATP binding
GO:0016301  kinase activity
GO:0046872  metal ion binding
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups