ligase IV, DNA, ATP-dependent

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Synonym

ligase IV, DNA, ATP-dependent, DNA ligase 4, ligase IV, Polydeoxyribonucleotide synthase [ATP] 4, 5830471N16Rik, Lig4, DNA ligase IV

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:33 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:38.20 spine:- retina:32.10 eye:15.20 artery/aorta:- vein:- lymphnode:10.80 peripheral blood:- spleen:13.20 thymus:49.40 bone marrow:12.80 adipose:- bone:- skin:7.90
GeneChip nodata
CAGE cerebrum:2.02 cerebellum:- brain stem:2.30 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:2.11 retina:- eye:- artery/aorta:2.16 vein:- lymphnode:1.86 peripheral blood:- spleen:1.87 thymus:3.95 bone marrow:- adipose:- bone:2.29 skin:1.84
RNA-seq cerebrum:0.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:13.80 prostate:- ovary:- testis:14.80 heart:- muscle:- esophagus:- stomach:32.70 intestine:- colon:17.60     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:19.60 salivary:-
GeneChip nodata
CAGE uterus:1.90 placenta:1.75 prostate:2.06 ovary:1.71 testis:4.40 heart:- muscle:- esophagus:- stomach:1.35 intestine:2.10 colon:1.89     liver/hepato:2.06    lung:2.25 bladder:2.17 kidney:- pituitary:2.29 thyroid/parathyroid:- adrenal gland:1.80 pancreas:2.03 breast:2.01 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:1.32 esophagus:- stomach:- intestine:- colon:-     liver/hepato:1.30        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_176953
Gene ID 319583
Unigene ID Mm.80584
Probe set ID -
Ensembl ID ENSMUSG00000049717

Orthologous Gene

Human[3]  NM_001098268, NM_002312, NM_206937
Rat [0]  

Chromosomal Region

8A1.1  [9,970,020  -  9,977,686]

Gene Family (Interpro ID)

IPR012310  ATP dependent DNA ligase, central

Link to Pubmed  (Pubmed ID)

9823897
9875844
9889105
10349636
10607596
10716994
10823907
10911993
10922068
11040211
11042159
11076861
11217851
11248063
11779495
11885597
11896201
12110179
12438222
12466851
12531011
12846809
14500378
14681479
15175260
15194694
15968270
16141072
16141073
16357942
16547499
16565260
16602821
16777961
17145779
17241822
17492771
17535972
17554302
17713479
18451109
18799693
18854157
18931659
19001141
19056826
19056883
19057578
19076778
19164512
19171781
19174520
19451691
19596237
19615340
19833883
20010689
20133615
20133803
20142431
20620605
21160476
21245316
21267068
21282644
21390131
21655080
21734301
21857671
22308491
22392994
22522401
22556254
22670056
23345425
23861962

Gene Ontology  (GO ID)

Biological Process

GO:0007049  cell cycle
GO:0051301  cell division
GO:0008283  cell proliferation
GO:0007417  central nervous system development
GO:0051276  chromosome organization
GO:0006266  DNA ligation
GO:0051102  DNA ligation during DNA recombination
GO:0051103  DNA ligation during DNA repair
GO:0006310  DNA recombination
GO:0006281  DNA repair
GO:0006260  DNA replication
GO:0006302  double-strand break repair
GO:0006303  double-strand break repair via nonhomologous end joining
GO:0033152  immunoglobulin V(D)J recombination
GO:0001701  in utero embryonic development
GO:0045190  isotype switching
GO:0006273  lagging strand elongation
GO:0043524  negative regulation of neuron apoptosis
GO:0051402  neuron apoptosis
GO:0006289  nucleotide-excision repair
GO:0006297  nucleotide-excision repair, DNA gap filling
GO:0048146  positive regulation of fibroblast proliferation
GO:0050769  positive regulation of neurogenesis
GO:0002328  pro-B cell differentiation
GO:0006974  response to DNA damage stimulus
GO:0010332  response to gamma radiation
GO:0010212  response to ionizing radiation
GO:0010165  response to X-ray
GO:0000012  single strand break repair
GO:0035019  somatic stem cell maintenance
GO:0033077  T cell differentiation in the thymus
GO:0033153  T cell receptor V(D)J recombination
GO:0033151  V(D)J recombination

Cellular Component

GO:0005694  chromosome
GO:0000793  condensed chromosome
GO:0005737  cytoplasm
GO:0032807  DNA ligase IV complex
GO:0005958  DNA-dependent protein kinase-DNA ligase 4 complex
GO:0005925  focal adhesion
GO:0070419  nonhomologous end joining complex
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0003677  DNA binding
GO:0003910  DNA ligase (ATP) activity
GO:0003909  DNA ligase activity
GO:0016874  ligase activity
GO:0046872  metal ion binding
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding