Rho guanine nucleotide exchange factor (GEF) 3

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Synonym

C76747, Rho guanine nucleotide exchange factor 3, Rho guanine nucleotide exchange factor (GEF) 3, Arhgef3, 9830169H03Rik, 1200004I24Rik

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:31.30 cerebellum:110.50 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:152.90 spine:- retina:- eye:7.60 artery/aorta:- vein:- lymphnode:64.80 peripheral blood:43.10 spleen:105.30 thymus:69.20 bone marrow:25.60 adipose:- bone:50.10 skin:15.80
GeneChip cerebrum:7.31 cerebellum:7.24 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:6.66 spine:6.74 retina:5.81 eye:5.88 artery/aorta:- vein:6.90 lymphnode:8.90 peripheral blood:- spleen:8.05 thymus:- bone marrow:7.21 adipose:6.49 bone:7.23 skin:6.91
CAGE cerebrum:4.52 cerebellum:- brain stem:3.42 corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:3.07 retina:- eye:- artery/aorta:3.97 vein:- lymphnode:5.51 peripheral blood:- spleen:4.15 thymus:4.07 bone marrow:- adipose:- bone:3.83 skin:3.80
RNA-seq cerebrum:5.39 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:43.60 placenta:55.20 prostate:30.90 ovary:- testis:96.10 heart:74.40 muscle:35.50 esophagus:- stomach:98.20 intestine:- colon:-     liver/hepato:36.20        lung:60.30    bladder:- kidney:48.40 pituitary:- thyroid/parathyroid:112.50 adrenal gland:848.90 pancreas:18.80 breast:58.80 salivary:54
GeneChip uterus:6.92 placenta:7.99 prostate:7.32 ovary:7.30 testis:5.21 heart:6.90 muscle:6.53 esophagus:- stomach:7.07 intestine:6.71 colon:- liver/hepato:7.14 lung:9 bladder:7.13 kidney:7.03 pituitary:6.79 thyroid/parathyroid:- adrenal gland:7.22 pancreas:5.73 breast:6.90 salivary:6.82
CAGE uterus:3.82 placenta:4.01 prostate:4.24 ovary:4.03 testis:2.51 heart:- muscle:- esophagus:- stomach:3.51 intestine:2.58 colon:3.46     liver/hepato:3.84    lung:5.30 bladder:3.87 kidney:- pituitary:3.49 thyroid/parathyroid:- adrenal gland:4.05 pancreas:3.27 breast:3.85 salivary:-
RNA-seq uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:2.12 esophagus:- stomach:- intestine:- colon:-     liver/hepato:2.95        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-

Gene Information

IDs

Refseq ID NM_027871
Gene ID 71704
Unigene ID Mm.248606
Probe set ID 1424250_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000021895

Orthologous Gene

Human[3]  NM_001128615, NM_001128616, NM_019555
Rat[1]  NM_001106061, NM_001128616, NM_019555

Chromosomal Region

-

Gene Family (Interpro ID)

IPR001849  Pleckstrin homology

Link to Pubmed  (Pubmed ID)

8889548
10349636
10725249
10922068
11042159
11076861
11217851
11839749
12221096
12466851
12477932
12520002
12799088
14610273
15489334
16141072
16141073
16602821
16632597
18799693
21267068
21677750
23192023
24043828

Gene Ontology  (GO ID)

Biological Process

GO:0035023  regulation of Rho protein signal transduction

Cellular Component

GO:0005737  cytoplasm
GO:0005622  intracellular

Molecular Function

GO:0005085  guanyl-nucleotide exchange factor activity
GO:0005543  phospholipid binding
GO:0005089  Rho guanyl-nucleotide exchange factor activity