histone deacetylase 5

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Synonym

KIAA0600, Histone deacetylase 5, NY-CO-9, HD5, HDAC5, Antigen NY-CO-9, histone deacetylase 5

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:48.60

cerebellum:25.20

brain stem:-

corpus callosum/glia:29.20

pineal gland:-

peripheral nerve:92

spine:112.30

retina:-

eye:111.70

artery/aorta:-

vein:-

lymphnode:80.90

peripheral blood:18.20

spleen:18.90

thymus:51.50

bone marrow:78.70

adipose:121

bone:38.40

skin:4.80

GeneChip

cerebrum:7.02

cerebellum:6.85

brain stem:7.24

corpus callosum/glia:6.85

pineal gland:-

peripheral nerve:6.47

spine:6.55

retina:-

eye:-

artery/aorta:7.27

vein:7.03

lymphnode:6.63

peripheral blood:-

spleen:6.78

thymus:6.33

bone marrow:6.18

adipose:6.85

bone:-

skin:7.19

CAGE

cerebrum:4.14

cerebellum:-

brain stem:4.19

corpus callosum/glia:4.32

pineal gland:4.55

peripheral nerve:-

spine:3.67

retina:-

eye:-

artery/aorta:4.01

vein:3.82

lymphnode:3.15

peripheral blood:-

spleen:3.37

thymus:3.28

bone marrow:-

adipose:3.60

bone:-

skin:-

RNA-seq

cerebrum:1.32

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.02

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.81

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:45.60

placenta:54.60

prostate:33.80

ovary:111.80

testis:38.90

heart:63.90

muscle:20.10

esophagus:-

stomach:-

intestine:-

colon:42.40

liver/hepato:10.60

lung:29.30

bladder:-

kidney:31.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:133.40

breast:27.90

salivary:-

GeneChip

uterus:6.52

placenta:7.57

prostate:6.45

ovary:6.79

testis:6.60

heart:6.90

muscle:7.19

esophagus:7.24

stomach:6.18

intestine:6.38

colon:6.30

liver/hepato:6.16

lung:6.95

bladder:-

kidney:6.61

pituitary:7.30

thyroid/parathyroid:6.90

adrenal gland:6.75

pancreas:6.61

breast:6.91

salivary:6.57

CAGE

uterus:3.99

placenta:4.21

prostate:4.01

ovary:3.89

testis:3.57

heart:3.74

muscle:3.60

esophagus:3.86

stomach:-

intestine:3.24

colon:3.58

liver/hepato:2.91

lung:3.59

bladder:4.04

kidney:2.98

pituitary:3.76

thyroid/parathyroid:3.98

adrenal gland:-

pancreas:3.13

breast:4.29

salivary:3.24

RNA-seq

uterus:-

placenta:-

prostate:1.04

ovary:2.22

testis:1.51

heart:1.70

muscle:3.74

esophagus:-

stomach:-

intestine:-

colon:2.88

liver/hepato:1.33

lung:2.73

bladder:-

kidney:1.34

pituitary:-

thyroid/parathyroid:2.07

adrenal gland:0.01

pancreas:-

breast:1.68

salivary:-

IDs

Refseq ID	NM_005474
Gene ID	10014
Unigene ID	Hs.438782
Probe set ID	202455_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000108840
GTEx ID	ENSG00000108840

Orthologous Gene

Mouse[2]	NM_001077696, NM_010412
Rat [0]

Chromosomal Region

17q21.31 [42,154,121 - 42,201,014]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR017320	Histone deacetylase class II, eukaryotic
IPR000286	Histone deacetylase superfamily

Gene Ontology (GO ID)

Biological Process

GO:0042113	B cell activation
GO:0030183	B cell differentiation
GO:0032869	cellular response to insulin stimulus
GO:0016568	chromatin modification
GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006342	chromatin silencing
GO:0007507	heart development
GO:0016575	histone deacetylation
GO:0006954	inflammatory response
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
GO:0010832	negative regulation of myotube differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0007219	Notch signaling pathway
GO:0002076	osteoblast development
GO:0051091	positive regulation of transcription factor activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0010830	regulation of myotube differentiation
GO:0043393	regulation of protein binding
GO:0042220	response to cocaine
GO:0006351	transcription, DNA-dependent

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005794	Golgi apparatus
GO:0000118	histone deacetylase complex
GO:0016604	nuclear body
GO:0005730	nucleolus
GO:0005654	nucleoplasm
GO:0005634	nucleus

Molecular Function

GO:0044212	DNA regulatory region binding
GO:0004407	histone deacetylase activity
GO:0046872	metal ion binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0005515	protein binding
GO:0005080	protein kinase C binding
GO:0003714	transcription corepressor activity
GO:0008134	transcription factor binding
GO:0070491	transcription repressor binding

histone deacetylase 5

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function