nuclear receptor subfamily 1, group H, member 3

Synonym

Nuclear orphan receptor LXR-alpha, LXRA, LXR-a, Liver X receptor alpha, NR1H3, nuclear receptor subfamily 1, group H, member 3, RLD-1, Oxysterols receptor LXR-alpha

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:13

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:5.90

artery/aorta:60

vein:-

lymphnode:-

peripheral blood:637.70

spleen:208

thymus:64.40

bone marrow:-

adipose:363

bone:102.40

skin:4.80

GeneChip

cerebrum:4.75

cerebellum:4.19

brain stem:4.90

corpus callosum/glia:4.85

pineal gland:-

peripheral nerve:6.39

spine:5.06

retina:-

eye:-

artery/aorta:5.75

vein:4.78

lymphnode:5.88

peripheral blood:-

spleen:5.72

thymus:4.85

bone marrow:4.36

adipose:6.71

bone:-

skin:5.62

CAGE

cerebrum:1.90

cerebellum:-

brain stem:2.04

corpus callosum/glia:1.96

pineal gland:1.94

peripheral nerve:-

spine:1.93

retina:-

eye:-

artery/aorta:2.36

vein:3.34

lymphnode:3.23

peripheral blood:-

spleen:4.05

thymus:2.12

bone marrow:-

adipose:4.72

bone:-

skin:-

RNA-seq

cerebrum:0.39

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.21

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.41

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:27.30

placenta:29.10

prostate:67.60

ovary:37.30

testis:26

heart:102.20

muscle:60.30

esophagus:-

stomach:-

intestine:64.80

colon:33.90

liver/hepato:31.70

lung:58.70

bladder:-

kidney:83.20

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:8.90

breast:9.30

salivary:-

GeneChip

uterus:5.07

placenta:5.84

prostate:5.37

ovary:4.98

testis:6.47

heart:4.80

muscle:4.62

esophagus:4.39

stomach:5.08

intestine:5.38

colon:5.55

liver/hepato:6.92

lung:5.11

bladder:-

kidney:5.68

pituitary:4.58

thyroid/parathyroid:5.34

adrenal gland:5.44

pancreas:5.05

breast:5.89

salivary:4.70

CAGE

uterus:2.33

placenta:3.07

prostate:2.77

ovary:2.33

testis:2.97

heart:2.35

muscle:1.54

esophagus:2.30

stomach:-

intestine:2.99

colon:3.11

liver/hepato:3.50

lung:2.85

bladder:2.39

kidney:2.19

pituitary:1.17

thyroid/parathyroid:2.50

adrenal gland:-

pancreas:2.18

breast:3.56

salivary:2.12

RNA-seq

uterus:-

placenta:-

prostate:0.18

ovary:0.65

testis:0.32

heart:0.44

muscle:0.18

esophagus:-

stomach:-

intestine:-

colon:0.31

liver/hepato:0.10

lung:0.29

bladder:-

kidney:0.59

pituitary:-

thyroid/parathyroid:1.14

adrenal gland:1.76

pancreas:-

breast:0.87

salivary:-

IDs

Refseq ID	NM_001130101
Gene ID	10062
Unigene ID	Hs.438863
Probe set ID	203920_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000025434
GTEx ID	ENSG00000025434

Orthologous Gene

Mouse[1]	NM_001177730, NM_013839
Rat [0]

Chromosomal Region

11p11.2 [47,269,851 - 47,290,396]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR003069	Ecdysteroid receptor
IPR001723	Steroid hormone receptor
IPR001728	Thyroid hormone receptor
IPR013088	Zinc finger, NHR/GATA-type
IPR001628	Zinc finger, nuclear hormone receptor-type

Gene Ontology (GO ID)

Biological Process

GO:0043277	apoptotic cell clearance
GO:0044255	cellular lipid metabolic process
GO:0071222	cellular response to lipopolysaccharide
GO:0042632	cholesterol homeostasis
GO:0010467	gene expression
GO:0055088	lipid homeostasis
GO:0010887	negative regulation of cholesterol storage
GO:0050728	negative regulation of inflammatory response
GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway
GO:0032369	negative regulation of lipid transport
GO:0043031	negative regulation of macrophage activation
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0090188	negative regulation of pancreatic juice secretion
GO:0048550	negative regulation of pinocytosis
GO:0045861	negative regulation of proteolysis
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0032270	positive regulation of cellular protein metabolic process
GO:0010875	positive regulation of cholesterol efflux
GO:0032376	positive regulation of cholesterol transport
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0010870	positive regulation of receptor biosynthetic process
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0042752	regulation of circadian rhythm
GO:0032570	response to progesterone stimulus
GO:0055092	sterol homeostasis
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0000790	nuclear chromatin
GO:0005654	nucleoplasm
GO:0005634	nucleus

Molecular Function

GO:0015485	cholesterol binding
GO:0003677	DNA binding
GO:0044212	DNA regulatory region binding
GO:0004879	ligand-dependent nuclear receptor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0003707	steroid hormone receptor activity
GO:0032810	sterol response element binding
GO:0003713	transcription coactivator activity
GO:0008270	zinc ion binding

nuclear receptor subfamily 1, group H, member 3

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function