cyclin-dependent kinase 6

Synonym

PLSTIRE, CDK6, cyclin-dependent kinase 6, MGC59692, Cell division protein kinase 6, Serine/threonine-protein kinase PLSTIRE

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:30.80

cerebellum:25.20

brain stem:-

corpus callosum/glia:87.50

pineal gland:890.10

peripheral nerve:-

spine:112.30

retina:-

eye:64.60

artery/aorta:-

vein:66.60

lymphnode:283.10

peripheral blood:127.50

spleen:-

thymus:283.40

bone marrow:216.50

adipose:-

bone:-

skin:100.80

GeneChip

cerebrum:5.09

cerebellum:4.75

brain stem:5.18

corpus callosum/glia:5.02

pineal gland:-

peripheral nerve:5.03

spine:5.02

retina:-

eye:-

artery/aorta:4.89

vein:5.10

lymphnode:5.02

peripheral blood:-

spleen:4.80

thymus:5.72

bone marrow:5.48

adipose:5.08

bone:-

skin:5.27

CAGE

cerebrum:2.85

cerebellum:-

brain stem:3.29

corpus callosum/glia:3.51

pineal gland:4.46

peripheral nerve:-

spine:2.91

retina:-

eye:-

artery/aorta:3.00

vein:3.43

lymphnode:3.07

peripheral blood:-

spleen:3.06

thymus:5.27

bone marrow:-

adipose:3.18

bone:-

skin:-

RNA-seq

cerebrum:0.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.43

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:45.60

placenta:94.70

prostate:22.50

ovary:-

testis:69.20

heart:140.50

muscle:-

esophagus:-

stomach:127.50

intestine:64.80

colon:76.30

liver/hepato:285

lung:136.90

bladder:-

kidney:114.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:101.60

pancreas:35.60

breast:111.50

salivary:-

GeneChip

uterus:4.82

placenta:5.43

prostate:4.88

ovary:4.75

testis:5.89

heart:5.07

muscle:5.20

esophagus:4.79

stomach:5.10

intestine:4.99

colon:5.11

liver/hepato:4.96

lung:4.89

bladder:-

kidney:4.87

pituitary:4.81

thyroid/parathyroid:4.63

adrenal gland:5.02

pancreas:5.15

breast:4.84

salivary:4.79

CAGE

uterus:3.28

placenta:3.97

prostate:3.14

ovary:2.69

testis:2.63

heart:3.21

muscle:1.91

esophagus:3.35

stomach:-

intestine:3.46

colon:3.42

liver/hepato:2.80

lung:3.10

bladder:3.20

kidney:2.99

pituitary:2.56

thyroid/parathyroid:2.13

adrenal gland:-

pancreas:3.29

breast:2.91

salivary:2.69

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.00

testis:0.76

heart:0.08

muscle:0.00

esophagus:-

stomach:-

intestine:-

colon:0.09

liver/hepato:0.25

lung:0.68

bladder:-

kidney:0.17

pituitary:-

thyroid/parathyroid:0.00

adrenal gland:0.16

pancreas:-

breast:0.00

salivary:-

IDs

Refseq ID	NM_001145306
Gene ID	1021
Unigene ID	Hs.119882
Probe set ID	207143_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000105810
GTEx ID	ENSG00000105810

Orthologous Gene

Mouse[3]	NM_009873
Rat [0]

Chromosomal Region

7q21.2 [92,234,235 - 92,465,908]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0014002	astrocyte development
GO:0007050	cell cycle arrest
GO:0043697	cell dedifferentiation
GO:0051301	cell division
GO:0021542	dentate gyrus development
GO:0000080	G1 phase of mitotic cell cycle
GO:0000082	G1/S transition of mitotic cell cycle
GO:0048699	generation of neurons
GO:0042063	gliogenesis
GO:0021670	lateral ventricle development
GO:0000278	mitotic cell cycle
GO:0045786	negative regulation of cell cycle
GO:0045596	negative regulation of cell differentiation
GO:0008285	negative regulation of cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0003323	pancreatic B cell development
GO:0001954	positive regulation of cell-matrix adhesion
GO:0048146	positive regulation of fibroblast proliferation
GO:0006468	protein amino acid phosphorylation
GO:0045646	regulation of erythrocyte differentiation
GO:0010468	regulation of gene expression
GO:0009615	response to virus

Cellular Component

GO:0000307	cyclin-dependent protein kinase holoenzyme complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005634	nucleus
GO:0001726	ruffle

Molecular Function

GO:0005524	ATP binding
GO:0030332	cyclin binding
GO:0004693	cyclin-dependent protein kinase activity
GO:0005515	protein binding

cyclin-dependent kinase 6

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function