STIP1 homology and U-box containing protein 1

Synonym

PP1131, CHIP, STIP1 homology and U-box-containing protein 1, CLL-associated antigen KW-8, SDCCAG7, NY-CO-7, Carboxy terminus of Hsp70-interacting protein, STIP1 homology and U-box containing protein 1, STUB1, Antigen NY-CO-7, UBOX1, STIP1 homology and U box-containing protein 1, E3 ubiquitin protein ligase CHIP, HSPABP2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:91.30

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:61.30

spine:112.30

retina:-

eye:94

artery/aorta:-

vein:-

lymphnode:91

peripheral blood:-

spleen:-

thymus:-

bone marrow:118.10

adipose:-

bone:25.60

skin:76.80

GeneChip

cerebrum:8.65

cerebellum:8.51

brain stem:8.80

corpus callosum/glia:8.05

pineal gland:-

peripheral nerve:8.66

spine:8.22

retina:-

eye:-

artery/aorta:8.31

vein:7.89

lymphnode:7.97

peripheral blood:-

spleen:7.95

thymus:7.76

bone marrow:7.48

adipose:8.38

bone:-

skin:8.25

CAGE

cerebrum:4.65

cerebellum:-

brain stem:4.22

corpus callosum/glia:3.92

pineal gland:4.38

peripheral nerve:-

spine:4.56

retina:-

eye:-

artery/aorta:4.55

vein:3.95

lymphnode:4.01

peripheral blood:-

spleen:3.65

thymus:3.40

bone marrow:-

adipose:3.85

bone:-

skin:-

RNA-seq

cerebrum:4.75

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:4.59

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:4.72

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:82

placenta:40.10

prostate:101.40

ovary:37.30

testis:26

heart:51.10

muscle:140.60

esophagus:-

stomach:42.50

intestine:32.40

colon:76.30

liver/hepato:42.20

lung:78.20

bladder:-

kidney:52

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:35.60

breast:148.70

salivary:-

GeneChip

uterus:7.88

placenta:7.16

prostate:8.28

ovary:7.83

testis:7.78

heart:8.05

muscle:8.91

esophagus:8.32

stomach:7.91

intestine:7.98

colon:7.84

liver/hepato:8.05

lung:7.90

bladder:-

kidney:8.30

pituitary:8.57

thyroid/parathyroid:8.40

adrenal gland:8.39

pancreas:7.66

breast:8.25

salivary:8.28

CAGE

uterus:3.67

placenta:3.35

prostate:4.00

ovary:3.74

testis:3.81

heart:4.73

muscle:5.15

esophagus:3.97

stomach:-

intestine:3.63

colon:4.06

liver/hepato:4.04

lung:4.01

bladder:3.78

kidney:3.90

pituitary:3.89

thyroid/parathyroid:4.15

adrenal gland:-

pancreas:4.53

breast:4.73

salivary:4.36

RNA-seq

uterus:-

placenta:-

prostate:5.10

ovary:5.00

testis:4.81

heart:4.17

muscle:5.06

esophagus:-

stomach:-

intestine:-

colon:5.05

liver/hepato:3.60

lung:4.46

bladder:-

kidney:4.57

pituitary:-

thyroid/parathyroid:5.19

adrenal gland:4.84

pancreas:-

breast:5.25

salivary:-

IDs

Refseq ID	NM_005861
Gene ID	10273
Unigene ID	Hs.592081
Probe set ID	217934_x_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000103266
GTEx ID	ENSG00000103266

Orthologous Gene

Mouse[2]	NM_019719
Rat[1]	NM_001025625

Chromosomal Region

16p13.3 [730,276 - 732,753]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR019734	Tetratricopeptide repeat
IPR003613	U box domain
IPR013083	Zinc finger, RING/FYVE/PHD-type

Gene Ontology (GO ID)

Biological Process

GO:0071218	cellular response to misfolded protein
GO:0006281	DNA repair
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0090035	positive regulation of cellular chaperone-mediated protein complex assembly
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398	positive regulation of protein ubiquitination
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process
GO:0051865	protein autoubiquitination
GO:0070534	protein K63-linked ubiquitination
GO:0051604	protein maturation
GO:0000209	protein polyubiquitination
GO:0031943	regulation of glucocorticoid metabolic process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0030579	ubiquitin-dependent SMAD protein catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0042405	nuclear inclusion body
GO:0031371	ubiquitin conjugating enzyme complex
GO:0000151	ubiquitin ligase complex

Molecular Function

GO:0019899	enzyme binding
GO:0030544	Hsp70 protein binding
GO:0051879	Hsp90 protein binding
GO:0019900	kinase binding
GO:0051787	misfolded protein binding
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0042803	protein homodimerization activity
GO:0046332	SMAD binding
GO:0030911	TPR domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0004842	ubiquitin-protein ligase activity
GO:0034450	ubiquitin-ubiquitin ligase activity

STIP1 homology and U-box containing protein 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function