toll-interleukin 1 receptor (TIR) domain containing adaptor protein

 jump to detail

Synonym

MyD88 adapter-like protein, Adaptor protein Wyatt, FLJ42305, TIRAP, TIR domain-containing adapter protein, wyatt, Mal

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:8.30 cerebellum:25.20 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:30.70 spine:- retina:118.60 eye:17.60 artery/aorta:- vein:- lymphnode:30.30 peripheral blood:18.20 spleen:- thymus:12.90 bone marrow:19.70 adipose:- bone:- skin:33.60
GeneChip nodata
CAGE cerebrum:1.87 cerebellum:- brain stem:1.66 corpus callosum/glia:1.87 pineal gland:2.45 peripheral nerve:- spine:1.98 retina:- eye:- artery/aorta:2.81 vein:2.60 lymphnode:2.77 peripheral blood:- spleen:2.79 thymus:1.52 bone marrow:- adipose:2.42 bone:- skin:-
RNA-seq cerebrum:0.16 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.03 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.11 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:14.60 prostate:33.80 ovary:74.50 testis:- heart:12.80 muscle:20.10 esophagus:- stomach:1741.90 intestine:- colon:-     liver/hepato:-        lung:34.20    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:163.70 adrenal gland:- pancreas:26.70 breast:9.30 salivary:-
GeneChip nodata
CAGE uterus:2.73 placenta:2.40 prostate:2.68 ovary:2.65 testis:1.69 heart:2.46 muscle:2.31 esophagus:2.51 stomach:- intestine:3.04 colon:3.11     liver/hepato:2.76    lung:2.82 bladder:2.69 kidney:2.45 pituitary:2.57 thyroid/parathyroid:2.25 adrenal gland:- pancreas:2.98 breast:3.09 salivary:3.05
RNA-seq uterus:- placenta:- prostate:0.09 ovary:0.44 testis:0.06 heart:0.11 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.20     liver/hepato:0.08        lung:0.00    bladder:- kidney:0.29 pituitary:- thyroid/parathyroid:0.29 adrenal gland:0.21 pancreas:- breast:0.02 salivary:-

Gene Information

IDs

Refseq ID NM_148910
Gene ID 114609
Unigene ID Hs.537126
Probe set ID -
Ensembl ID ENSG00000150455
GTEx ID ENSG00000150455

Orthologous Gene

Mouse[1]  NM_001177845, NM_001177846, NM_001177847, NM_054096
Rat[1]  NM_001177845, NM_001177846, NM_001177847, NM_054096

Chromosomal Region

11q24.2  [126,152,960  -  126,168,740]

Gene Family (Interpro ID)

IPR000157  Toll-Interleukin receptor

Link to Pubmed  (Pubmed ID)

11526399
11544529
11572860
12062447
12083783
12447442
12477932
12565889
12721283
12724322
14517278
14530355
14625308
14630816
15004556
15123841
15187145
15247281
15276183
15294994
15489334
16024789
16284379
16301656
16415872
16439361
16751103
16968706
16991088
17161867
17258210
17322885
17538633
17610834
18070880
18180278
18221795
18292575
18305471
18369480
18417424
18438411
18583567
18810425
18987746
19120490
19317913
19378034
19456234
19505919
19509286
19509334
19543401
19574958
19592497
19602285
19627277
19693265
19913121
19948740
20016852
20048342
20164415
20188863
20196868
20237496
20400509
20448286
20525286
20577092
20588308
20628086
20797905
20804371
20822478
21048031
21118491
21218381
21324962
21398611
21399862
21419702
21457584
21705416
21829704
21873236
21899704
21903422
21988832
22221660
22593572
22683004
22685567
22970235
23002119
23047423
23255565
23297396
23382074
23419703
23460645
23766530
23802631
24064014
24067789
24084649
24275656

Gene Ontology  (GO ID)

Biological Process

GO:0070935  3'-UTR-mediated mRNA stabilization
GO:0007166  cell surface receptor linked signal transduction
GO:0071221  cellular response to bacterial lipopeptide
GO:0071223  cellular response to lipoteichoic acid
GO:0050830  defense response to Gram-positive bacterium
GO:0007249  I-kappaB kinase/NF-kappaB cascade
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0030099  myeloid cell differentiation
GO:0044130  negative regulation of growth of symbiont in host
GO:0030890  positive regulation of B cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032735  positive regulation of interleukin-12 production
GO:0032738  positive regulation of interleukin-15 production
GO:0045410  positive regulation of interleukin-6 biosynthetic process
GO:0032757  positive regulation of interleukin-8 production
GO:0046330  positive regulation of JNK cascade
GO:0090023  positive regulation of neutrophil chemotaxis
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0090073  positive regulation of protein homodimerization activity
GO:0034137  positive regulation of toll-like receptor 2 signaling pathway
GO:0034141  positive regulation of toll-like receptor 3 signaling pathway
GO:0034145  positive regulation of toll-like receptor 4 signaling pathway
GO:0032760  positive regulation of tumor necrosis factor production
GO:0045088  regulation of innate immune response
GO:0032648  regulation of interferon-beta production
GO:0032496  response to lipopolysaccharide
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0030139  endocytic vesicle
GO:0005886  plasma membrane
GO:0032587  ruffle membrane

Molecular Function

GO:0005546  phosphatidylinositol-4,5-bisphosphate binding
GO:0005515  protein binding
GO:0030674  protein binding, bridging
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0005080  protein kinase C binding