adaptor-related protein complex 2, sigma 1 subunit

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Synonym

AP17, Adapter-related protein complex 2 sigma-1 subunit, CLAPS2, Plasma membrane adaptor AP-2 17 kDa protein, Clathrin assembly protein 2 small chain, Clathrin coat-associated protein AP17, adaptor-related protein complex 2, sigma 1 subunit, HA2 17 kDa subunit, AP-2 complex subunit sigma-1, AP17-DELTA, AP2S1, Clathrin coat assembly protein AP17

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:35.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:112.30 retina:- eye:76.40 artery/aorta:- vein:- lymphnode:80.90 peripheral blood:- spleen:18.90 thymus:25.80 bone marrow:98.40 adipose:- bone:38.40 skin:38.40
GeneChip cerebrum:7.75 cerebellum:7.23 brain stem:7.92 corpus callosum/glia:6.80 pineal gland:- peripheral nerve:8.24 spine:7.26 retina:- eye:- artery/aorta:7.65 vein:7.65 lymphnode:7.68 peripheral blood:- spleen:7.55 thymus:8 bone marrow:8.22 adipose:7.81 bone:- skin:8.42
CAGE cerebrum:4.25 cerebellum:- brain stem:3.95 corpus callosum/glia:3.57 pineal gland:3.51 peripheral nerve:- spine:3.73 retina:- eye:- artery/aorta:3.91 vein:4.12 lymphnode:4.27 peripheral blood:- spleen:4.26 thymus:4.16 bone marrow:- adipose:4.26 bone:- skin:-
RNA-seq cerebrum:4.88 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.33 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.04 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:164 placenta:29.10 prostate:67.60 ovary:37.30 testis:30.30 heart:268.20 muscle:100.50 esophagus:- stomach:21.20 intestine:64.80 colon:110.20     liver/hepato:63.30        lung:73.30    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:27.90 salivary:-
GeneChip uterus:7.44 placenta:7.53 prostate:8.19 ovary:7.37 testis:7.99 heart:7.13 muscle:7.04 esophagus:8.43 stomach:6.98 intestine:7.58 colon:7.66 liver/hepato:7.49 lung:7.72 bladder:- kidney:7.43 pituitary:7.59 thyroid/parathyroid:7.39 adrenal gland:7.60 pancreas:7.40 breast:7.87 salivary:7.56
CAGE uterus:3.66 placenta:4.20 prostate:3.81 ovary:3.66 testis:4.07 heart:4.06 muscle:4.17 esophagus:4.54 stomach:- intestine:4.09 colon:4.43     liver/hepato:4.33    lung:4.22 bladder:3.99 kidney:4.18 pituitary:3.50 thyroid/parathyroid:3.86 adrenal gland:- pancreas:4.19 breast:4.35 salivary:4.07
RNA-seq uterus:- placenta:- prostate:5.03 ovary:4.52 testis:5.03 heart:4.05 muscle:4.72 esophagus:- stomach:- intestine:- colon:4.70     liver/hepato:5.35        lung:5.39    bladder:- kidney:4.92 pituitary:- thyroid/parathyroid:4.39 adrenal gland:5.39 pancreas:- breast:4.97 salivary:-

Gene Information

IDs

Refseq ID NM_004069
Gene ID 1175
Unigene ID Hs.119591
Probe set ID 208074_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000042753
GTEx ID ENSG00000042753

Orthologous Gene

Mouse[1]  NM_198613
Rat [0]  

Chromosomal Region

19q13.32  [47,341,423  -  47,354,203]

Gene Family (Interpro ID)

IPR016635  Adaptor protein complex, sigma subunit
IPR000804  Clathrin adaptor, sigma subunit/coatomer, zeta subunit

Link to Pubmed  (Pubmed ID)

2014052
2040623
2495531
7593184
9040778
9767099
9882340
10567358
10753805
11157096
12086608
12477932
12577067
15020715
15489334
16055064
16103193
16139856
17108326
17210199
17353931
19380743
19738201
20012524
21139048
21762802
21890473
21906983
21963094
21987572
21988832
22505724
22623428
23000965
23077317
23151229
23222959
23751493
23874206
24423332
24797263
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0019886  antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0007411  axon guidance
GO:0048268  clathrin coat assembly
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0006886  intracellular protein transport
GO:0042059  negative regulation of epidermal growth factor receptor signaling pathway
GO:0048011  nerve growth factor receptor signaling pathway
GO:0050690  regulation of defense response to virus by virus
GO:0030100  regulation of endocytosis
GO:0007268  synaptic transmission
GO:0016032  viral reproduction

Cellular Component

GO:0030122  AP-2 adaptor complex
GO:0030669  clathrin-coated endocytic vesicle membrane
GO:0005829  cytosol
GO:0030666  endocytic vesicle membrane
GO:0005886  plasma membrane

Molecular Function

GO:0008565  protein transporter activity
GO:0005215  transporter activity