adrenergic, beta, receptor kinase 1

Synonym

G-protein coupled receptor kinase 2, BETA-ARK1, BARK, Beta-adrenergic receptor kinase 1, adrenergic, beta, receptor kinase 1, Beta-ARK-1, BARK1, GRK2, ADRBK1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:26.10

cerebellum:12.60

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:122.70

spine:112.30

retina:-

eye:64.60

artery/aorta:30

vein:-

lymphnode:323.50

peripheral blood:109.30

spleen:56.70

thymus:103.10

bone marrow:413.30

adipose:80.70

bone:25.60

skin:172.80

GeneChip

cerebrum:8.42

cerebellum:8.64

brain stem:8.32

corpus callosum/glia:8.50

pineal gland:-

peripheral nerve:8.46

spine:8.53

retina:-

eye:-

artery/aorta:8.35

vein:8.22

lymphnode:8.47

peripheral blood:-

spleen:8.45

thymus:8.22

bone marrow:8.62

adipose:8.47

bone:-

skin:8.19

CAGE

cerebrum:3.46

cerebellum:-

brain stem:3.24

corpus callosum/glia:3.14

pineal gland:2.62

peripheral nerve:-

spine:3.23

retina:-

eye:-

artery/aorta:3.17

vein:3.93

lymphnode:4.20

peripheral blood:-

spleen:4.18

thymus:4.01

bone marrow:-

adipose:2.59

bone:-

skin:-

RNA-seq

cerebrum:3.79

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:5.35

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.64

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:36.50

placenta:32.80

prostate:101.40

ovary:149.10

testis:21.60

heart:-

muscle:40.20

esophagus:-

stomach:106.20

intestine:64.80

colon:110.20

liver/hepato:21.10

lung:58.70

bladder:-

kidney:20.80

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:8.90

breast:46.50

salivary:-

GeneChip

uterus:8.16

placenta:8.57

prostate:7.89

ovary:8.16

testis:8.16

heart:8.33

muscle:8.26

esophagus:8.35

stomach:8.55

intestine:8.42

colon:8.45

liver/hepato:8.25

lung:8.44

bladder:-

kidney:8.36

pituitary:8.82

thyroid/parathyroid:8.34

adrenal gland:8.40

pancreas:9.05

breast:8.19

salivary:8.73

CAGE

uterus:2.97

placenta:3.08

prostate:3.22

ovary:2.63

testis:2.66

heart:3.07

muscle:3.28

esophagus:3.14

stomach:-

intestine:3.55

colon:3.57

liver/hepato:2.81

lung:3.61

bladder:2.92

kidney:2.59

pituitary:2.62

thyroid/parathyroid:2.33

adrenal gland:-

pancreas:2.41

breast:3.38

salivary:3.17

RNA-seq

uterus:-

placenta:-

prostate:3.73

ovary:3.68

testis:3.34

heart:3.13

muscle:3.68

esophagus:-

stomach:-

intestine:-

colon:3.57

liver/hepato:2.84

lung:4.21

bladder:-

kidney:3.34

pituitary:-

thyroid/parathyroid:3.22

adrenal gland:5.10

pancreas:-

breast:3.22

salivary:-

IDs

Refseq ID	NM_001619
Gene ID	156
Unigene ID	Hs.83636
Probe set ID	38447_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000173020
GTEx ID	ENSG00000173020

Orthologous Gene

Mouse[2]	NM_130863
Rat [0]

Chromosomal Region

11q13.2 [67,033,881 - 67,054,027]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0007202	activation of phospholipase C activity
GO:0060048	cardiac muscle contraction
GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0007507	heart development
GO:0045087	innate immune response
GO:0007213	muscarinic acetylcholine receptor signaling pathway
GO:0045988	negative regulation of striated muscle contraction
GO:0003108	negative regulation of the force of heart contraction by chemical signal
GO:0048011	nerve growth factor receptor signaling pathway
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0033605	positive regulation of catecholamine secretion
GO:0031623	receptor internalization
GO:0007165	signal transduction
GO:0007217	tachykinin receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0005886	plasma membrane

Molecular Function

GO:0031694	alpha-2A adrenergic receptor binding
GO:0005524	ATP binding
GO:0047696	beta-adrenergic receptor kinase activity
GO:0031755	Edg-2 lysophosphatidic acid receptor binding
GO:0004703	G-protein coupled receptor kinase activity
GO:0005543	phospholipid binding
GO:0005515	protein binding
GO:0004672	protein kinase activity

IPR000961	AGC-kinase, C-terminal
IPR001849	Pleckstrin homology
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR000342	Regulator of G protein signalling
IPR016137	Regulator of G protein signalling superfamily
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

adrenergic, beta, receptor kinase 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function