cytochrome P450, family 27, subfamily B, polypeptide 1

Synonym

VDR, VDDRI, VDDR I, CYP1ALPHA, CP2B, P450C1 alpha, Calcidiol 1-monooxygenase, CYP27B, 25-OHD-1 alpha-hydroxylase, PDDR, P450c1, Cytochrome P450 subfamily XXVIIB polypeptide 1, VD3 1A hydroxylase, P450VD1-alpha, CYP1alpha, VDDR, CYP27B1, Cytochrome p450 27B1, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase, VDD1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:1.20

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:52.90

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:54.70

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:5.07

cerebellum:5.19

brain stem:5.03

corpus callosum/glia:5.03

pineal gland:-

peripheral nerve:5.13

spine:5.25

retina:-

eye:-

artery/aorta:5.18

vein:5.07

lymphnode:5.15

peripheral blood:-

spleen:4.97

thymus:5.04

bone marrow:5.24

adipose:5.19

bone:-

skin:5.12

CAGE

cerebrum:0

cerebellum:-

brain stem:0

corpus callosum/glia:0

pineal gland:0

peripheral nerve:-

spine:0

retina:-

eye:-

artery/aorta:0

vein:0

lymphnode:0.15

peripheral blood:-

spleen:0

thymus:0.37

bone marrow:-

adipose:0

bone:-

skin:-

RNA-seq

cerebrum:0.05

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.24

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.04

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:4.30

heart:-

muscle:-

esophagus:-

stomach:42.50

intestine:-

colon:-

liver/hepato:-

lung:4.90

bladder:125.60

kidney:353.50

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:26.70

breast:18.60

salivary:-

GeneChip

uterus:4.99

placenta:5

prostate:4.97

ovary:4.84

testis:4.98

heart:5.01

muscle:5.03

esophagus:4.95

stomach:5.15

intestine:5.26

colon:5.26

liver/hepato:5.08

lung:4.94

bladder:-

kidney:6.57

pituitary:5.25

thyroid/parathyroid:5.61

adrenal gland:5.28

pancreas:5.91

breast:5.12

salivary:5.15

CAGE

uterus:0.19

placenta:0.08

prostate:0.08

ovary:0

testis:0.07

heart:0

muscle:0

esophagus:0.18

stomach:-

intestine:0.14

colon:0.08

liver/hepato:0

lung:0.31

bladder:0

kidney:3.54

pituitary:0

thyroid/parathyroid:0.41

adrenal gland:-

pancreas:1.74

breast:0

salivary:0.36

RNA-seq

uterus:-

placenta:-

prostate:0.25

ovary:0.11

testis:0.96

heart:0.01

muscle:0

esophagus:-

stomach:-

intestine:-

colon:0

liver/hepato:0.13

lung:0.22

bladder:-

kidney:4.16

pituitary:-

thyroid/parathyroid:1.10

adrenal gland:0.22

pancreas:-

breast:0.19

salivary:-

IDs

Refseq ID	NM_000785
Gene ID	1594
Unigene ID	Hs.524528
Probe set ID	205676_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000111012
GTEx ID	ENSG00000111012

Orthologous Gene

Mouse[1]	NM_010009
Rat[1]	NM_010009

Chromosomal Region

12q14.1 [58,156,117 - 58,161,034]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001128	Cytochrome P450
IPR002397	Cytochrome P450, B-class
IPR002401	Cytochrome P450, E-class, group I
IPR002403	Cytochrome P450, E-class, group IV

Gene Ontology (GO ID)

Biological Process

GO:0030282	bone mineralization
GO:0055074	calcium ion homeostasis
GO:0006816	calcium ion transport
GO:0046697	decidualization
GO:0070314	G1 to G0 transition
GO:0010956	negative regulation of calcidiol 1-monooxygenase activity
GO:0030308	negative regulation of cell growth
GO:0008285	negative regulation of cell proliferation
GO:0045618	positive regulation of keratinocyte differentiation
GO:0010980	positive regulation of vitamin D 24-hydroxylase activity
GO:0070564	positive regulation of vitamin D receptor signaling pathway
GO:0030500	regulation of bone mineralization
GO:0043627	response to estrogen stimulus
GO:0034341	response to interferon-gamma
GO:0032496	response to lipopolysaccharide
GO:0033280	response to vitamin D
GO:0008202	steroid metabolic process
GO:0042369	vitamin D catabolic process
GO:0042359	vitamin D metabolic process
GO:0006766	vitamin metabolic process
GO:0006805	xenobiotic metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0005739	mitochondrion

Molecular Function

GO:0004498	calcidiol 1-monooxygenase activity
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0005506	iron ion binding

cytochrome P450, family 27, subfamily B, polypeptide 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function