cytochrome P450, family 51, subfamily A, polypeptide 1

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Synonym

P450-14DM, P45014DM, CP51, Cytochrome P450 51A1, CYPLI, CYP51, Sterol 14-alpha demethylase, CYP51A1, CYPL1, P450LI, P450L1, Lanosterol 14-alpha demethylase, LDM

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:100.70 cerebellum:25.20 brain stem:- corpus callosum/glia:145.80 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:17.60 artery/aorta:- vein:- lymphnode:40.40 peripheral blood:36.40 spleen:18.90 thymus:- bone marrow:- adipose:40.30 bone:12.80 skin:67.20
GeneChip cerebrum:6.88 cerebellum:6.42 brain stem:7.09 corpus callosum/glia:7.14 pineal gland:- peripheral nerve:7.56 spine:7.74 retina:- eye:- artery/aorta:5.77 vein:5.91 lymphnode:5.57 peripheral blood:- spleen:5.42 thymus:4.99 bone marrow:5.46 adipose:5.90 bone:- skin:5.98
CAGE cerebrum:3.95 cerebellum:- brain stem:4.47 corpus callosum/glia:4.71 pineal gland:3.84 peripheral nerve:- spine:4.37 retina:- eye:- artery/aorta:3.24 vein:2.71 lymphnode:3.14 peripheral blood:- spleen:3.25 thymus:2.18 bone marrow:- adipose:3.64 bone:- skin:-
RNA-seq cerebrum:3.11 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.76 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.80 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:29.10 prostate:67.60 ovary:74.50 testis:281.20 heart:51.10 muscle:20.10 esophagus:- stomach:63.70 intestine:32.40 colon:118.70     liver/hepato:52.80        lung:48.90    bladder:- kidney:72.80 pituitary:- thyroid/parathyroid:163.70 adrenal gland:253.90 pancreas:97.80 breast:65.10 salivary:-
GeneChip uterus:6.10 placenta:5.68 prostate:7.13 ovary:6.68 testis:9.65 heart:6.07 muscle:5.38 esophagus:6.48 stomach:6.32 intestine:6.68 colon:6.42 liver/hepato:7.23 lung:6.45 bladder:- kidney:6.11 pituitary:6.21 thyroid/parathyroid:5.68 adrenal gland:7.36 pancreas:7.09 breast:5.87 salivary:5.79
CAGE uterus:3.31 placenta:3.12 prostate:3.16 ovary:4.26 testis:4.74 heart:2.89 muscle:2.18 esophagus:4.13 stomach:- intestine:4.54 colon:3.87     liver/hepato:4.90    lung:4.31 bladder:3.46 kidney:4.11 pituitary:3.49 thyroid/parathyroid:3.41 adrenal gland:- pancreas:4.11 breast:3.78 salivary:3.54
RNA-seq uterus:- placenta:- prostate:2.42 ovary:4.09 testis:4.16 heart:1.34 muscle:1.99 esophagus:- stomach:- intestine:- colon:2.14     liver/hepato:3.11        lung:3.16    bladder:- kidney:2.98 pituitary:- thyroid/parathyroid:3.08 adrenal gland:2.25 pancreas:- breast:2.43 salivary:-

Gene Information

IDs

Refseq ID NM_000786
Gene ID 1595
Unigene ID Hs.417077
Probe set ID 216607_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000001630
GTEx ID ENSG00000001630

Orthologous Gene

Mouse[3]  NM_020010
Rat [0]  

Chromosomal Region

7q21.2  [91,741,465  -  91,772,266]

Gene Family (Interpro ID)

IPR001128  Cytochrome P450
IPR002397  Cytochrome P450, B-class
IPR002401  Cytochrome P450, E-class, group I
IPR002403  Cytochrome P450, E-class, group IV

Link to Pubmed  (Pubmed ID)

8024575
8619637
8797093
8809088
8845856
8975714
11678326
12145339
12477932
12690205
12824470
12853948
14702039
15128046
15489334
15611056
16344560
18660489
18676367
19322201
19946888
20149798
20547249
21139048
21890473
21906983
21963094
21987572
21988832
22053931
22180046
23000965
24362992
24502137
24654937

Gene Ontology  (GO ID)

Biological Process

GO:0006695  cholesterol biosynthetic process
GO:0033488  cholesterol biosynthetic process via 24,25-dihydrolanosterol
GO:0006694  steroid biosynthetic process
GO:0016125  sterol metabolic process
GO:0006805  xenobiotic metabolic process

Cellular Component

GO:0005789  endoplasmic reticulum membrane
GO:0016021  integral to membrane

Molecular Function

GO:0009055  electron carrier activity
GO:0020037  heme binding
GO:0005506  iron ion binding
GO:0008398  sterol 14-demethylase activity