discs, large homolog 1 (Drosophila)

 jump to detail

Synonym

SAP-97, hdlg, dJ1061C18.1.1, DLGH1, DKFZp761P0818, Synapse-associated protein 97, SAP97, Disks large homolog 1, DLG1, hDlg, discs, large homolog 1 (Drosophila)

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:59.30 cerebellum:75.60 brain stem:- corpus callosum/glia:58.30 pineal gland:296.70 peripheral nerve:92 spine:- retina:118.60 eye:88.20 artery/aorta:- vein:- lymphnode:303.30 peripheral blood:- spleen:18.90 thymus:77.30 bone marrow:157.40 adipose:40.30 bone:12.80 skin:139.20
GeneChip cerebrum:8.81 cerebellum:9.04 brain stem:8.70 corpus callosum/glia:9.27 pineal gland:- peripheral nerve:7.63 spine:8.78 retina:- eye:- artery/aorta:7.58 vein:7.42 lymphnode:7.48 peripheral blood:- spleen:7.34 thymus:8.08 bone marrow:6.71 adipose:7.82 bone:- skin:7.87
CAGE cerebrum:4.44 cerebellum:- brain stem:4.62 corpus callosum/glia:4.66 pineal gland:3.25 peripheral nerve:- spine:4.05 retina:- eye:- artery/aorta:3.32 vein:3.08 lymphnode:3.27 peripheral blood:- spleen:3.08 thymus:3.72 bone marrow:- adipose:3.52 bone:- skin:-
RNA-seq cerebrum:1.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.09 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.93 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:76.50 prostate:225.30 ovary:74.50 testis:38.90 heart:51.10 muscle:40.20 esophagus:- stomach:42.50 intestine:32.40 colon:101.80     liver/hepato:84.40        lung:48.90    bladder:- kidney:145.60 pituitary:116 thyroid/parathyroid:- adrenal gland:152.40 pancreas:97.80 breast:185.90 salivary:-
GeneChip uterus:7.88 placenta:7.89 prostate:7.89 ovary:7.84 testis:7.17 heart:7.32 muscle:7.57 esophagus:8.10 stomach:7.84 intestine:7.69 colon:7.30 liver/hepato:7.62 lung:7.53 bladder:- kidney:7.57 pituitary:7.91 thyroid/parathyroid:8.51 adrenal gland:7.56 pancreas:6.69 breast:7.94 salivary:7.64
CAGE uterus:3.50 placenta:3.54 prostate:3.31 ovary:3.16 testis:3.10 heart:3.04 muscle:3.13 esophagus:3.84 stomach:- intestine:3.89 colon:3.73     liver/hepato:3.03    lung:3.29 bladder:3.42 kidney:3.58 pituitary:4.06 thyroid/parathyroid:3.87 adrenal gland:- pancreas:2.90 breast:3.02 salivary:3.29
RNA-seq uterus:- placenta:- prostate:2.77 ovary:2.86 testis:2.76 heart:2.63 muscle:3.89 esophagus:- stomach:- intestine:- colon:3.12     liver/hepato:2.20        lung:1.77    bladder:- kidney:3.04 pituitary:- thyroid/parathyroid:2.33 adrenal gland:1.38 pancreas:- breast:3.74 salivary:-

Gene Information

IDs

Refseq ID NM_004087
Gene ID 1739
Unigene ID Hs.292549
Probe set ID 202515_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000075711
GTEx ID ENSG00000075711

Orthologous Gene

Mouse[2]  NM_007862
Rat [0]  

Chromosomal Region

3q29  [196,769,431  -  197,026,171]

Gene Family (Interpro ID)

IPR008144  Guanylate kinase
IPR008145  Guanylate kinase/L-type calcium channel
IPR004172  L27

Link to Pubmed  (Pubmed ID)

5024025
7477295
7937897
8601796
8825652
8889548
8922391
8938729
9024696
9115257
9148889
9192623
9286858
9341123
9512503
9677374
9756850
9786987
9808460
10336672
10595517
10619846
10646847
10656683
10779557
10859302
10939335
10993877
11060025
11134026
11140673
11181181
11274188
11279111
11440998
11567040
11572861
11602598
11723125
11726633
11997254
12050163
12067714
12070168
12081647
12097473
12151521
12175853
12189141
12351654
12419826
12477932
12507520
12511555
12668732
12713445
12763866
12766944
12807908
12857860
12860415
12902344
12933808
12970345
14699157
14960569
15021905
15024025
15221964
15286176
15302935
15485825
15673434
15699074
15729360
16228013
16316992
16466689
16473877
16482544
16619250
16637659
16825666
17069616
17172448
17237226
17332497
17574238
17696365
17713926
17980554
18245566
18311135
18461433
18665322
18725271
18760273
18793635
18930083
18946087
19017653
19066288
19086053
19118189
19213956
19307009
19586902
19615732
19841189
20201926
20356847
20379614
20398908
20551903
20605917
20643107
20691406
20702775
20980075
21041448
21113079
21139048
21164104
21489588
21595829
21615688
21762802
21849460
21850710
21858148
21890473
21906983
21963094
22004035
22027822
22185284
22225629
22272285
22307621
22377151
22378744
22383878
22434720
22657348
22745667
22792261
23000965
23532850
23576434
23624197
23782696
23864692
24324269
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0007015  actin filament organization
GO:0032147  activation of protein kinase activity
GO:0042982  amyloid precursor protein metabolic process
GO:0007411  axon guidance
GO:0001658  branching involved in ureteric bud morphogenesis
GO:0016337  cell-cell adhesion
GO:0030866  cortical actin cytoskeleton organization
GO:0048704  embryonic skeletal system morphogenesis
GO:0001935  endothelial cell proliferation
GO:0007163  establishment or maintenance of cell polarity
GO:0001771  formation of immunological synapse
GO:0060022  hard palate development
GO:0002088  lens development in camera-type eye
GO:0031579  membrane raft organization
GO:0007093  mitotic cell cycle checkpoint
GO:0050680  negative regulation of epithelial cell proliferation
GO:0045930  negative regulation of mitotic cell cycle
GO:0042130  negative regulation of T cell proliferation
GO:0030432  peristalsis
GO:0030838  positive regulation of actin filament polymerization
GO:0008284  positive regulation of cell proliferation
GO:0090004  positive regulation of establishment of protein localization in plasma membrane
GO:0043268  positive regulation of potassium ion transport
GO:0042391  regulation of membrane potential
GO:0048608  reproductive structure development
GO:0048745  smooth muscle tissue development
GO:0007268  synaptic transmission
GO:0042110  T cell activation
GO:0002369  T cell cytokine production
GO:0070830  tight junction assembly
GO:0019048  virus-host interaction

Cellular Component

GO:0016323  basolateral plasma membrane
GO:0030054  cell junction
GO:0031253  cell projection membrane
GO:0005911  cell-cell junction
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0005794  Golgi apparatus
GO:0001772  immunological synapse
GO:0014704  intercalated disc
GO:0009898  internal side of plasma membrane
GO:0043219  lateral loop
GO:0016328  lateral plasma membrane
GO:0045121  membrane raft
GO:0005874  microtubule
GO:0031594  neuromuscular junction
GO:0033268  node of Ranvier
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane
GO:0042383  sarcolemma
GO:0005923  tight junction

Molecular Function

GO:0008092  cytoskeletal protein binding
GO:0004385  guanylate kinase activity
GO:0031434  mitogen-activated protein kinase kinase binding
GO:0019902  phosphatase binding
GO:0004721  phosphoprotein phosphatase activity
GO:0015459  potassium channel regulator activity
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0032947  protein complex scaffold
GO:0019901  protein kinase binding