elastase, neutrophil expressed

Synonym

PMN elastase, Medullasin, HLE, Human leukocyte elastase, ELA2, PMN-E, elastase 2, neutrophil, Bone marrow serine protease, Leukocyte elastase precursor, Elastase-2, HNE, NE, Neutrophil elastase

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:11.80

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:127.50

spleen:-

thymus:12.90

bone marrow:236.20

adipose:-

bone:12.80

skin:-

GeneChip

cerebrum:3.97

cerebellum:4.04

brain stem:3.91

corpus callosum/glia:4.01

pineal gland:-

peripheral nerve:3.92

spine:3.88

retina:-

eye:-

artery/aorta:4.25

vein:4.42

lymphnode:4.42

peripheral blood:-

spleen:4.57

thymus:5.90

bone marrow:12.22

adipose:4.43

bone:-

skin:4.56

CAGE

cerebrum:0.05

cerebellum:-

brain stem:0.03

corpus callosum/glia:0.55

pineal gland:0

peripheral nerve:-

spine:0

retina:-

eye:-

artery/aorta:0.47

vein:0.79

lymphnode:0.55

peripheral blood:-

spleen:2.22

thymus:2.93

bone marrow:-

adipose:0.14

bone:-

skin:-

RNA-seq

cerebrum:0.12

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.31

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:4.04

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:-

ovary:-

testis:-

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:-

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:3.86

placenta:3.98

prostate:3.88

ovary:3.81

testis:3.72

heart:4.04

muscle:4.36

esophagus:4.13

stomach:3.99

intestine:4.47

colon:6.46

liver/hepato:3.80

lung:4.85

bladder:-

kidney:3.92

pituitary:3.93

thyroid/parathyroid:3.99

adrenal gland:4.14

pancreas:4.68

breast:4.07

salivary:3.98

CAGE

uterus:0

placenta:1.57

prostate:0

ovary:0.14

testis:0.04

heart:1.59

muscle:0.30

esophagus:0.09

stomach:-

intestine:0

colon:0

liver/hepato:0.46

lung:1.56

bladder:0.09

kidney:0

pituitary:0.24

thyroid/parathyroid:1.02

adrenal gland:-

pancreas:0.94

breast:0

salivary:0

RNA-seq

uterus:-

placenta:-

prostate:0.32

ovary:0.37

testis:0.51

heart:0.31

muscle:0.02

esophagus:-

stomach:-

intestine:-

colon:0.70

liver/hepato:0.42

lung:4.31

bladder:-

kidney:0.16

pituitary:-

thyroid/parathyroid:0.42

adrenal gland:0.37

pancreas:-

breast:0.43

salivary:-

IDs

Refseq ID	NM_001972
Gene ID	1991
Unigene ID	Hs.99863
Probe set ID	206871_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000197561
GTEx ID	ENSG00000197561

Orthologous Gene

Mouse[1]	NM_015779
Rat[1]	NM_001106767

Chromosomal Region

19p13.3 [852,291 - 856,242]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

LRG_57 [5,001 - 8,956]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001254	Peptidase S1/S6, chymotrypsin/Hap
IPR001314	Peptidase S1A, chymotrypsin
IPR009003	Serine/cysteine peptidase, trypsin-like

Gene Ontology (GO ID)

Biological Process

GO:0002438	acute inflammatory response to antigenic stimulus
GO:0006874	cellular calcium ion homeostasis
GO:0030574	collagen catabolic process
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0050900	leukocyte migration
GO:0045079	negative regulation of chemokine biosynthetic process
GO:0050922	negative regulation of chemotaxis
GO:0044130	negative regulation of growth of symbiont in host
GO:0050728	negative regulation of inflammatory response
GO:0045415	negative regulation of interleukin-8 biosynthetic process
GO:0070947	neutrophil mediated killing of fungus
GO:0006909	phagocytosis
GO:0050778	positive regulation of immune response
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0043406	positive regulation of MAP kinase activity
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0030163	protein catabolic process
GO:0006508	proteolysis
GO:0032496	response to lipopolysaccharide
GO:0009411	response to UV
GO:0001878	response to yeast

Cellular Component

GO:0009986	cell surface
GO:0005576	extracellular region
GO:0030141	secretory granule

Molecular Function

GO:0019955	cytokine binding
GO:0004175	endopeptidase activity
GO:0008201	heparin binding
GO:0008233	peptidase activity
GO:0002020	protease binding
GO:0005515	protein binding
GO:0004252	serine-type endopeptidase activity

elastase, neutrophil expressed

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function