EPH receptor A5

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Synonym

EphA5, TYRO4, HEK7, Ephrin type-A receptor 5 precursor, EPHA5, Receptor protein-tyrosine kinase HEK7, EPH homology kinase 1, CEK7, EHK1, Tyrosine-protein kinase receptor EHK-1, EPH receptor A5, Hek7

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:4.38 cerebellum:3.78 brain stem:4.66 corpus callosum/glia:3.79 pineal gland:- peripheral nerve:4.46 spine:4.16 retina:- eye:- artery/aorta:3.46 vein:3.48 lymphnode:3.40 peripheral blood:- spleen:3.37 thymus:3.28 bone marrow:3.32 adipose:3.52 bone:- skin:3.59
CAGE cerebrum:3.74 cerebellum:- brain stem:2.91 corpus callosum/glia:2.52 pineal gland:5.94 peripheral nerve:- spine:4.36 retina:- eye:- artery/aorta:1.48 vein:1.03 lymphnode:0.54 peripheral blood:- spleen:0.56 thymus:0.06 bone marrow:- adipose:0.14 bone:- skin:-
RNA-seq cerebrum:1.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.09 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:3.82 placenta:3.61 prostate:4.29 ovary:3.29 testis:3.79 heart:3.31 muscle:3.40 esophagus:3.29 stomach:3.10 intestine:3.48 colon:3.05 liver/hepato:3.44 lung:3.17 bladder:- kidney:3.24 pituitary:3.92 thyroid/parathyroid:3.75 adrenal gland:3.27 pancreas:3.57 breast:3.35 salivary:3.26
CAGE uterus:2.30 placenta:1.02 prostate:2.28 ovary:2.12 testis:0.77 heart:1.27 muscle:0.13 esophagus:0.57 stomach:- intestine:0.14 colon:0.61     liver/hepato:0    lung:0.28 bladder:1.15 kidney:0.08 pituitary:3.38 thyroid/parathyroid:2.48 adrenal gland:- pancreas:0 breast:0.90 salivary:1.89
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.00 testis:0.00 heart:0.00 muscle:0 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0        lung:0.00    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_004439
Gene ID 2044
Unigene ID -
Probe set ID 215664_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000145242
GTEx ID ENSG00000145242

Orthologous Gene

Mouse[2]  NM_007937
Rat [0]  

Chromosomal Region

4q13.1  [66,185,281  -  66,536,213]

Gene Family (Interpro ID)

IPR001090  Ephrin receptor, ligand binding
IPR003961  Fibronectin, type III
IPR008957  Fibronectin, type III-like fold
IPR008979  Galactose-binding domain-like
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001660  Sterile alpha motif
IPR010993  Sterile alpha motif homology
IPR013761  Sterile alpha motif-type
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR016257  Tyrosine-protein kinase, ephrin receptor
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7528718
7898931
7973638
8755474
9191074
9267020
9321686
9321687
9530499
9576626
10064801
10207129
10375373
10516308
10531456
10607706
10730216
11076863
11128993
11230166
11256076
12477932
15485908
15489336
16381901
16737551
19733895
19949912
19953087
20379614
20596523
22079638
22174851
23824631
24029132
24086308

Gene Ontology  (GO ID)

Biological Process

GO:0007411  axon guidance
GO:0019933  cAMP-mediated signaling
GO:0048013  ephrin receptor signaling pathway
GO:0021766  hippocampus development
GO:0051964  negative regulation of synaptogenesis
GO:0048666  neuron development
GO:0032793  positive regulation of CREB transcription factor activity
GO:0032956  regulation of actin cytoskeleton organization
GO:0032314  regulation of Rac GTPase activity

Cellular Component

GO:0030424  axon
GO:0043025  cell soma
GO:0030425  dendrite
GO:0009897  external side of plasma membrane
GO:0005887  integral to plasma membrane
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0005791  rough endoplasmic reticulum

Molecular Function

GO:0005524  ATP binding
GO:0005003  ephrin receptor activity
GO:0005004  GPI-linked ephrin receptor activity
GO:0005005  transmembrane-ephrin receptor activity