v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

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Synonym

c-erb B2, Her-2/neu, HER2, c-erbB-2, ErbB2/neu, NGL, C-erbB-2, NEU, HER2-neu, NEU proto-oncogene, p185erbB2, HER-2/neu, c-erbB2/neu, c-erbB-2/neu, Her2/neu, Tyrosine kinase-type cell surface receptor HER2, HER 2, HER-2, Receptor tyrosine-protein kinase erbB-2 precursor, TKR1, ERBB2, MLN 19, ErbB-2/neu

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:16.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:214.70 spine:112.30 retina:- eye:129.30 artery/aorta:- vein:- lymphnode:20.20 peripheral blood:- spleen:37.80 thymus:- bone marrow:19.70 adipose:40.30 bone:- skin:100.80
GeneChip cerebrum:6.25 cerebellum:6.01 brain stem:6.46 corpus callosum/glia:6.51 pineal gland:- peripheral nerve:8.41 spine:7.09 retina:- eye:- artery/aorta:8.29 vein:7.34 lymphnode:7.16 peripheral blood:- spleen:6.31 thymus:6.33 bone marrow:5.95 adipose:7.30 bone:- skin:8.32
CAGE cerebrum:2.36 cerebellum:- brain stem:2.09 corpus callosum/glia:3.05 pineal gland:2.63 peripheral nerve:- spine:2.62 retina:- eye:- artery/aorta:3.96 vein:2.84 lymphnode:3.04 peripheral blood:- spleen:2.26 thymus:1.80 bone marrow:- adipose:2.63 bone:- skin:-
RNA-seq cerebrum:0.94 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.30 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.48 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:120.20 prostate:78.90 ovary:74.50 testis:- heart:38.30 muscle:- esophagus:- stomach:21.20 intestine:- colon:610.50     liver/hepato:10.60        lung:92.90    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:492.50 salivary:656.80
GeneChip uterus:7.48 placenta:9.45 prostate:8.59 ovary:7.92 testis:6.86 heart:7.59 muscle:6.87 esophagus:8.65 stomach:7.70 intestine:7.67 colon:8.13 liver/hepato:7.83 lung:8.16 bladder:- kidney:9.26 pituitary:7.20 thyroid/parathyroid:8.41 adrenal gland:6.61 pancreas:6.77 breast:8.75 salivary:8.33
CAGE uterus:3.68 placenta:4.80 prostate:4.00 ovary:3.76 testis:2.92 heart:3.63 muscle:2.92 esophagus:4.37 stomach:- intestine:4.61 colon:4.31     liver/hepato:3.68    lung:3.92 bladder:3.42 kidney:4.36 pituitary:2.62 thyroid/parathyroid:4.28 adrenal gland:- pancreas:3.42 breast:2.95 salivary:4.19
RNA-seq uterus:- placenta:- prostate:0.15 ovary:1.42 testis:1.60 heart:1.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.09     liver/hepato:0.92        lung:0.00    bladder:- kidney:0.42 pituitary:- thyroid/parathyroid:1.47 adrenal gland:1.37 pancreas:- breast:0.53 salivary:-

IDs

Refseq ID NM_001005862
Gene ID 2064
Unigene ID Hs.446352
Probe set ID 216836_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000141736
GTEx ID ENSG00000141736

Orthologous Gene

Mouse[2]  NM_001003817
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

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Gene Ontology  (GO ID)

Biological Process

GO:0007411  axon guidance
GO:0008283  cell proliferation
GO:0007166  cell surface receptor linked signal transduction
GO:0007167  enzyme linked receptor protein signaling pathway
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0007507  heart development
GO:0045087  innate immune response
GO:0030879  mammary gland development
GO:0008045  motor axon guidance
GO:0042552  myelination
GO:0033088  negative regulation of immature T cell proliferation in the thymus
GO:0048011  nerve growth factor receptor signaling pathway
GO:0007399  nervous system development
GO:0007528  neuromuscular junction development
GO:0007422  peripheral nervous system development
GO:0014065  phosphoinositide 3-kinase cascade
GO:0048015  phosphoinositide-mediated signaling
GO:0045785  positive regulation of cell adhesion
GO:0030307  positive regulation of cell growth
GO:0050679  positive regulation of epithelial cell proliferation
GO:0043406  positive regulation of MAP kinase activity
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0032321  positive regulation of Rho GTPase activity
GO:0045943  positive regulation of transcription from RNA polymerase I promoter
GO:0045945  positive regulation of transcription from RNA polymerase III promoter
GO:0045727  positive regulation of translation
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0045765  regulation of angiogenesis
GO:0070372  regulation of ERK1 and ERK2 cascade
GO:0032886  regulation of microtubule-based process
GO:0007165  signal transduction
GO:0006351  transcription, DNA-dependent
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060  wound healing

Cellular Component

GO:0016324  apical plasma membrane
GO:0016323  basolateral plasma membrane
GO:0010008  endosome membrane
GO:0016021  integral to membrane
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0043235  receptor complex

Molecular Function

GO:0005524  ATP binding
GO:0005006  epidermal growth factor receptor activity
GO:0043125  ErbB-3 class receptor binding
GO:0019838  growth factor binding
GO:0042802  identical protein binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0046983  protein dimerization activity
GO:0046982  protein heterodimerization activity
GO:0019903  protein phosphatase binding
GO:0004713  protein tyrosine kinase activity
GO:0004716  receptor signaling protein tyrosine kinase activity
GO:0004888  transmembrane receptor activity
GO:0004714  transmembrane receptor protein tyrosine kinase activity