excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)

Synonym

ERCC3, DNA-repair protein complementing XP-B cells, XPBC, BTF2-p89, GTF2H, Basic transcription factor 2 89 kDa subunit, RAD25, XPB, DNA excision repair protein ERCC-3, TFIIH 89 kDa subunit

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:190.80

cerebellum:201.50

brain stem:-

corpus callosum/glia:233.30

pineal gland:-

peripheral nerve:-

spine:224.60

retina:-

eye:35.30

artery/aorta:149.90

vein:133.30

lymphnode:161.80

peripheral blood:36.40

spleen:151.30

thymus:270.60

bone marrow:98.40

adipose:201.70

bone:51.20

skin:72

GeneChip

cerebrum:6.63

cerebellum:6.98

brain stem:6.66

corpus callosum/glia:6.67

pineal gland:-

peripheral nerve:6.61

spine:6.33

retina:-

eye:-

artery/aorta:6.24

vein:5.80

lymphnode:6.79

peripheral blood:-

spleen:6.87

thymus:7.27

bone marrow:6.25

adipose:6.45

bone:-

skin:6.40

CAGE

cerebrum:3.44

cerebellum:-

brain stem:3.33

corpus callosum/glia:3.31

pineal gland:3.21

peripheral nerve:-

spine:3.14

retina:-

eye:-

artery/aorta:3.31

vein:3.35

lymphnode:2.95

peripheral blood:-

spleen:3.12

thymus:3.28

bone marrow:-

adipose:2.90

bone:-

skin:-

RNA-seq

cerebrum:3.19

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.81

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.46

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:118.50

placenta:18.20

prostate:202.80

ovary:-

testis:151.40

heart:76.60

muscle:40.20

esophagus:-

stomach:21.20

intestine:97.20

colon:8.50

liver/hepato:31.70

lung:78.20

bladder:376.80

kidney:135.20

pituitary:232

thyroid/parathyroid:-

adrenal gland:152.40

pancreas:26.70

breast:27.90

salivary:328.40

GeneChip

uterus:6.80

placenta:6.16

prostate:6.69

ovary:6.89

testis:7.45

heart:5.93

muscle:6.39

esophagus:6.40

stomach:6.28

intestine:6.15

colon:6.04

liver/hepato:5.94

lung:6.54

bladder:-

kidney:6.11

pituitary:6.86

thyroid/parathyroid:6.65

adrenal gland:6.46

pancreas:6.14

breast:6.70

salivary:6.11

CAGE

uterus:3.33

placenta:2.90

prostate:3.22

ovary:3.00

testis:3.87

heart:2.96

muscle:3.24

esophagus:2.90

stomach:-

intestine:2.69

colon:2.80

liver/hepato:2.93

lung:2.98

bladder:2.87

kidney:2.90

pituitary:3.32

thyroid/parathyroid:2.83

adrenal gland:-

pancreas:3.02

breast:2.91

salivary:3.17

RNA-seq

uterus:-

placenta:-

prostate:3.92

ovary:3.51

testis:4.53

heart:2.66

muscle:3.18

esophagus:-

stomach:-

intestine:-

colon:2.71

liver/hepato:2.77

lung:2.37

bladder:-

kidney:3.21

pituitary:-

thyroid/parathyroid:3.52

adrenal gland:3.70

pancreas:-

breast:3.05

salivary:-

IDs

Refseq ID	NM_000122
Gene ID	2071
Unigene ID	Hs.469872
Probe set ID	202176_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000163161
GTEx ID	ENSG00000163161

Orthologous Gene

Mouse[1]	NM_133658
Rat[1]	NM_001031644

Chromosomal Region

2q14.3 [128,014,866 - 128,051,752]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR014001	DEAD-like helicase, N-terminal
IPR014021	Helicase, superfamily 1/2, ATP-binding domain

Gene Ontology (GO ID)

Biological Process

GO:0000075	cell cycle checkpoint
GO:0006281	DNA repair
GO:0006265	DNA topological change
GO:0010467	gene expression
GO:0035315	hair cell differentiation
GO:0006917	induction of apoptosis
GO:0006370	mRNA capping
GO:0006289	nucleotide-excision repair
GO:0000718	nucleotide-excision repair, DNA damage removal
GO:0000717	nucleotide-excision repair, DNA duplex unwinding
GO:0033683	nucleotide-excision repair, DNA incision
GO:0043065	positive regulation of apoptosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050434	positive regulation of viral transcription
GO:0008104	protein localization
GO:0001666	response to hypoxia
GO:0006979	response to oxidative stress
GO:0009411	response to UV
GO:0006362	RNA elongation from RNA polymerase I promoter
GO:0006368	RNA elongation from RNA polymerase II promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0006360	transcription from RNA polymerase I promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0009650	UV protection
GO:0016032	viral reproduction
GO:0019048	virus-host interaction

Cellular Component

GO:0005675	holo TFIIH complex
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0000441	SSL2-core TFIIH complex

Molecular Function

GO:0043138	3'-5' DNA helicase activity
GO:0005524	ATP binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0016887	ATPase activity
GO:0003684	damaged DNA binding
GO:0032564	dATP binding
GO:0003677	DNA binding
GO:0008094	DNA-dependent ATPase activity
GO:0005525	GTP binding
GO:0042277	peptide binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0004672	protein kinase activity
GO:0047485	protein N-terminus binding
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
GO:0008134	transcription factor binding

excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function