fer (fps/fes related) tyrosine kinase

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Synonym

Proto-oncogene tyrosine-protein kinase FER, c-FER, p94-FER, TYK3, FER

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:23.70 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:112.30 retina:118.60 eye:35.30 artery/aorta:30 vein:- lymphnode:- peripheral blood:18.20 spleen:18.90 thymus:25.80 bone marrow:19.70 adipose:- bone:12.80 skin:14.40
GeneChip cerebrum:5.95 cerebellum:5.83 brain stem:6.05 corpus callosum/glia:6.02 pineal gland:- peripheral nerve:6.25 spine:6.30 retina:- eye:- artery/aorta:6.28 vein:6.39 lymphnode:5.81 peripheral blood:- spleen:5.57 thymus:5.77 bone marrow:5.71 adipose:5.98 bone:- skin:6.25
CAGE cerebrum:3.04 cerebellum:- brain stem:3.05 corpus callosum/glia:2.70 pineal gland:3.25 peripheral nerve:- spine:3.67 retina:- eye:- artery/aorta:2.77 vein:2.29 lymphnode:1.98 peripheral blood:- spleen:2.78 thymus:2.50 bone marrow:- adipose:3.45 bone:- skin:-
RNA-seq cerebrum:1.47 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.95 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.12 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:43.70 prostate:22.50 ovary:- testis:30.30 heart:12.80 muscle:- esophagus:- stomach:21.20 intestine:- colon:17     liver/hepato:63.30        lung:29.30    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:46.50 salivary:-
GeneChip uterus:6.20 placenta:5.98 prostate:6.06 ovary:6 testis:7.38 heart:5.98 muscle:5.82 esophagus:6.32 stomach:5.82 intestine:5.71 colon:5.59 liver/hepato:5.63 lung:5.87 bladder:- kidney:5.67 pituitary:5.85 thyroid/parathyroid:6 adrenal gland:5.86 pancreas:5.88 breast:5.84 salivary:5.90
CAGE uterus:3.41 placenta:2.72 prostate:3.22 ovary:3.06 testis:2.95 heart:2.93 muscle:1.96 esophagus:2.93 stomach:- intestine:2.47 colon:2.33     liver/hepato:2.03    lung:3.20 bladder:3.21 kidney:2.68 pituitary:3.65 thyroid/parathyroid:3.02 adrenal gland:- pancreas:1.87 breast:2.95 salivary:1.89
RNA-seq uterus:- placenta:- prostate:1.27 ovary:1.80 testis:2.17 heart:1.17 muscle:0.33 esophagus:- stomach:- intestine:- colon:1.84     liver/hepato:0.42        lung:1.82    bladder:- kidney:1.15 pituitary:- thyroid/parathyroid:2.42 adrenal gland:1.31 pancreas:- breast:1.44 salivary:-

Gene Information

IDs

Refseq ID NM_005246
Gene ID 2241
Unigene ID Hs.221472
Probe set ID 206412_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000151422
GTEx ID ENSG00000151422

Orthologous Gene

Mouse[4]  NM_001037997, NM_008000
Rat[2]  NM_001106928, NM_008000

Chromosomal Region

5q21.3  [108,083,523  -  108,532,542]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR020685  Tyrosine-protein kinase
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020933  Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020764  Tyrosine-protein kinase, non-receptor Fes
IPR016250  Tyrosine-protein kinase, non-receptor Fes, subgroup
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

1651563
1663488
1990274
2156206
2209086
2685575
2725517
3350007
3472906
7623846
8247543
9722593
9742093
9742951
9748248
10411641
10878010
10921917
10998246
11006284
11994747
12118379
12477932
12640114
12738762
12871378
12972546
14517306
15226396
15324660
16273093
16732323
17192257
18029348
18271526
18985748
19147545
19339212
19738202
19835603
19913121
20628086
20881960
21122136
21518868
21700879
21890473
21906983
22223638
22238358
22939624
23445469
23699534
23873028
23906537
23931849

Gene Ontology  (GO ID)

Biological Process

GO:0031532  actin cytoskeleton reorganization
GO:0008283  cell proliferation
GO:0032869  cellular response to insulin stimulus
GO:0034614  cellular response to reactive oxygen species
GO:0006935  chemotaxis
GO:0019221  cytokine-mediated signaling pathway
GO:0050904  diapedesis
GO:0070102  interleukin-6-mediated signaling pathway
GO:0000226  microtubule cytoskeleton organization
GO:0000278  mitotic cell cycle
GO:0033007  negative regulation of mast cell activation during immune response
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0048008  platelet-derived growth factor receptor signaling pathway
GO:0030838  positive regulation of actin filament polymerization
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0042058  regulation of epidermal growth factor receptor signaling pathway
GO:0010762  regulation of fibroblast migration
GO:0010591  regulation of lamellipodium assembly
GO:0001932  regulation of protein amino acid phosphorylation
GO:0032496  response to lipopolysaccharide
GO:0034446  substrate adhesion-dependent cell spreading
GO:0042503  tyrosine phosphorylation of Stat3 protein

Cellular Component

GO:0015629  actin cytoskeleton
GO:0005938  cell cortex
GO:0030054  cell junction
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0031234  extrinsic to internal side of plasma membrane
GO:0030027  lamellipodium
GO:0015630  microtubule cytoskeleton
GO:0000790  nuclear chromatin
GO:0005634  nucleus

Molecular Function

GO:0003779  actin binding
GO:0005524  ATP binding
GO:0045296  cadherin binding
GO:0005154  epidermal growth factor receptor binding
GO:0045295  gamma-catenin binding
GO:0008289  lipid binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0019901  protein kinase binding
GO:0008157  protein phosphatase 1 binding
GO:0004713  protein tyrosine kinase activity
GO:0017137  Rab GTPase binding