FK506 binding protein 1A, 12kDa

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Synonym

FKBP1A, Immunophilin FKBP12, PKCI2, FK506 binding protein 1A, 12kDa, FKBP12C, FK506-binding protein 1A (12kD), PPIASE, PKC12, 12 kDa FKBP, FKBP-12, FKBP1, FK506-binding protein 1A, FKBP12

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:8.84 cerebellum:7.61 brain stem:7.86 corpus callosum/glia:8 pineal gland:- peripheral nerve:9.13 spine:8.10 retina:- eye:- artery/aorta:9.23 vein:9.01 lymphnode:9.21 peripheral blood:- spleen:9.26 thymus:9 bone marrow:9.30 adipose:9.68 bone:- skin:9.18
CAGE cerebrum:4.87 cerebellum:- brain stem:4.24 corpus callosum/glia:4.44 pineal gland:3.64 peripheral nerve:- spine:4.22 retina:- eye:- artery/aorta:5.07 vein:5.25 lymphnode:5.27 peripheral blood:- spleen:5.49 thymus:4.96 bone marrow:- adipose:5.96 bone:- skin:-
RNA-seq cerebrum:1.55 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.13 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.22 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:9.19 placenta:9.14 prostate:9.25 ovary:9.14 testis:7.76 heart:9.03 muscle:7.71 esophagus:9.08 stomach:8.92 intestine:9.04 colon:9.26 liver/hepato:7.98 lung:9.69 bladder:- kidney:8.72 pituitary:8.26 thyroid/parathyroid:9.52 adrenal gland:9.32 pancreas:8.35 breast:9.10 salivary:8.61
CAGE uterus:4.88 placenta:5.30 prostate:4.88 ovary:5.03 testis:4.52 heart:5.25 muscle:4.80 esophagus:5.01 stomach:- intestine:4.86 colon:4.89     liver/hepato:4.86    lung:5.37 bladder:4.94 kidney:4.98 pituitary:4.25 thyroid/parathyroid:5.36 adrenal gland:- pancreas:5.26 breast:5.48 salivary:4.58
RNA-seq uterus:- placenta:- prostate:1.42 ovary:2.00 testis:3.18 heart:0.65 muscle:0.76 esophagus:- stomach:- intestine:- colon:2.65     liver/hepato:1.27        lung:4.62    bladder:- kidney:1.24 pituitary:- thyroid/parathyroid:3.58 adrenal gland:2.97 pancreas:- breast:1.75 salivary:-

Gene Information

IDs

Refseq ID NM_054014
Gene ID 2280
Unigene ID -
Probe set ID 200709_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000088832
GTEx ID ENSG00000088832

Orthologous Gene

Mouse[8]  NM_008019
Rat[4]  NM_013102

Chromosomal Region

20p13  [1,349,622  -  1,373,806]

Gene Family (Interpro ID)

IPR001179  Peptidyl-prolyl cis-trans isomerase, FKBP-type

Link to Pubmed  (Pubmed ID)

1281998
1374404
1375171
1695378
1696686
1701173
1709301
1709302
1709363
1713687
1716149
1930186
2477715
7518616
7529739
7541038
7541044
7543369
7592869
7678431
7682113
7791754
7821789
7822316
8521476
8524402
8662507
8889548
8955134
9334222
9346894
9461216
9546659
9663660
9871618
9880681
10089303
10358090
10515881
10656803
10852943
11164950
11171121
11237759
11245643
11279144
11322937
11438723
11598113
11780052
11827452
11960000
12181673
12417722
12443530
12477932
12600203
12604780
12665801
12704193
12761501
12812497
12850152
14679009
14970260
15146197
15199065
15268862
15284440
15467718
15489334
15514157
15734648
15761148
15796538
15908921
15992823
16036432
16122887
16278292
16410343
16720724
16908189
17397867
17872463
17962721
18029417
18346205
18413763
19322201
19414059
19592636
19913121
20628086
21047202
21139048
21652707
21832049
21890473
22100703
22103444
22236651
22505724
22939629
22990118
23000965
23585572
23688288
23824909
24113748
24250222
24405377
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006458  'de novo' protein folding
GO:0034205  beta-amyloid formation
GO:0043206  fibril organization
GO:0003007  heart morphogenesis
GO:0060347  heart trabecula formation
GO:0032513  negative regulation of protein phosphatase type 2B activity
GO:0051280  negative regulation of release of sequestered calcium ion into cytosol
GO:0060315  negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0018208  peptidyl-proline modification
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032092  positive regulation of protein binding
GO:0031398  positive regulation of protein ubiquitination
GO:0006457  protein folding
GO:0022417  protein maturation by protein folding
GO:0000413  protein peptidyl-prolyl isomerization
GO:0042026  protein refolding
GO:0032925  regulation of activin receptor signaling pathway
GO:0050776  regulation of immune response
GO:0060314  regulation of ryanodine-sensitive calcium-release channel activity
GO:0007183  SMAD protein complex assembly
GO:0042110  T cell activation
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0055010  ventricular cardiac muscle tissue morphogenesis

Cellular Component

GO:0030424  axon
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0016020  membrane
GO:0033017  sarcoplasmic reticulum membrane
GO:0014802  terminal cisterna
GO:0030018  Z disc

Molecular Function

GO:0048185  activin binding
GO:0019855  calcium channel inhibitor activity
GO:0005528  FK506 binding
GO:0005527  macrolide binding
GO:0003755  peptidyl-prolyl cis-trans isomerase activity
GO:0005515  protein binding
GO:0005219  ryanodine-sensitive calcium-release channel activity
GO:0004871  signal transducer activity
GO:0046332  SMAD binding
GO:0005024  transforming growth factor beta receptor activity
GO:0005160  transforming growth factor beta receptor binding
GO:0034713  type I transforming growth factor beta receptor binding