lysine (K)-specific demethylase 2A

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Synonym

KIAA1004, FLJ00115, FBL7, DKFZP434M1735, CXXC8, LILINA, F-box protein FBL7, F-box/LRR-repeat protein 11, FLJ46431, F-box and leucine-rich repeat protein 11, JHDM1A, FBXL11, F-box protein Lilina, FBL11

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:56.90 cerebellum:12.60 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:92 spine:112.30 retina:- eye:182.20 artery/aorta:30 vein:133.30 lymphnode:121.30 peripheral blood:145.70 spleen:75.60 thymus:51.50 bone marrow:334.60 adipose:80.70 bone:64 skin:211.20
GeneChip cerebrum:7.68 cerebellum:7.94 brain stem:7.56 corpus callosum/glia:7.65 pineal gland:- peripheral nerve:7.92 spine:7.51 retina:- eye:- artery/aorta:8.01 vein:8.12 lymphnode:8.81 peripheral blood:- spleen:9.14 thymus:8.34 bone marrow:7.99 adipose:7.96 bone:- skin:8.10
CAGE cerebrum:3.72 cerebellum:- brain stem:3.64 corpus callosum/glia:3.64 pineal gland:3.88 peripheral nerve:- spine:3.50 retina:- eye:- artery/aorta:3.95 vein:4.05 lymphnode:4.21 peripheral blood:- spleen:4.02 thymus:4.01 bone marrow:- adipose:3.48 bone:- skin:-
RNA-seq cerebrum:1.82 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.24 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.84 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:127.60 placenta:91.10 prostate:22.50 ovary:74.50 testis:69.20 heart:89.40 muscle:40.20 esophagus:- stomach:127.50 intestine:- colon:144.20     liver/hepato:42.20        lung:68.40    bladder:- kidney:31.20 pituitary:232 thyroid/parathyroid:163.70 adrenal gland:- pancreas:71.10 breast:139.40 salivary:-
GeneChip uterus:8.09 placenta:7.93 prostate:7.96 ovary:8.17 testis:8.55 heart:7.98 muscle:7.59 esophagus:8.94 stomach:8.38 intestine:7.82 colon:8.11 liver/hepato:8.70 lung:8.33 bladder:- kidney:8.27 pituitary:7.74 thyroid/parathyroid:8.24 adrenal gland:8.34 pancreas:7.41 breast:8.52 salivary:8.08
CAGE uterus:3.86 placenta:3.89 prostate:3.62 ovary:3.56 testis:3.67 heart:3.54 muscle:3.27 esophagus:3.82 stomach:- intestine:3.57 colon:3.59     liver/hepato:3.29    lung:3.62 bladder:3.87 kidney:3.46 pituitary:3.76 thyroid/parathyroid:3.66 adrenal gland:- pancreas:3.37 breast:3.35 salivary:3.76
RNA-seq uterus:- placenta:- prostate:0.00 ovary:3.32 testis:1.65 heart:1.96 muscle:2.06 esophagus:- stomach:- intestine:- colon:1.22     liver/hepato:0.00        lung:0.03    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:3.24 adrenal gland:1.08 pancreas:- breast:2.30 salivary:-

Gene Information

IDs

Refseq ID NM_012308
Gene ID 22992
Unigene ID Hs.124147
Probe set ID 208987_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000173120
GTEx ID ENSG00000173120

Orthologous Gene

Mouse[1]  NM_001001984
Rat[1]  NM_001108515

Chromosomal Region

11q13.2  [66,886,740  -  67,025,141]

Gene Family (Interpro ID)

IPR003347  Transcription factor jumonji/aspartyl beta-hydroxylase
IPR019787  Zinc finger, PHD-finger
IPR001965  Zinc finger, PHD-type

Link to Pubmed  (Pubmed ID)

10231032
10531035
10531037
10945468
11214971
12168954
12477932
14702039
15070733
15231748
15489334
15635413
16147992
16362057
17081983
17463251
19001877
19322201
19805303
19850743
20080798
20379134
20417597
20682791
20936779
21029866
21139048
21187428
21251613
21609845
21890473
21988832
22083960
22100412
22635273
23074094
23537643
23559091
24200691
24457600
24482232

Gene Ontology  (GO ID)

Biological Process

GO:0070544  histone H3-K36 demethylation
GO:0006355  regulation of transcription, DNA-dependent
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0000790  nuclear chromatin
GO:0005654  nucleoplasm

Molecular Function

GO:0051864  histone demethylase activity (H3-K36 specific)
GO:0016702  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0045322  unmethylated CpG binding
GO:0008270  zinc ion binding