forkhead box J1

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Synonym

HFH-4, Forkhead-related protein FKHL13, FOXJ1, forkhead box J1, Hepatocyte nuclear factor 3 forkhead homolog 4, MGC35202, FKHL13, HFH4, Forkhead box protein J1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:5.88 cerebellum:5.98 brain stem:5.92 corpus callosum/glia:6.54 pineal gland:- peripheral nerve:5.42 spine:5.77 retina:- eye:- artery/aorta:5.50 vein:5.86 lymphnode:5.42 peripheral blood:- spleen:5.25 thymus:4.96 bone marrow:5.53 adipose:5.49 bone:- skin:5.56
CAGE cerebrum:0.91 cerebellum:- brain stem:0.97 corpus callosum/glia:3.29 pineal gland:0.64 peripheral nerve:- spine:0.90 retina:- eye:- artery/aorta:2.34 vein:0.18 lymphnode:0.26 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.92 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.02 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.09 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.59 placenta:5.17 prostate:4.93 ovary:6.60 testis:6.10 heart:6.01 muscle:5.98 esophagus:5.51 stomach:5.56 intestine:5.76 colon:5.98 liver/hepato:5.59 lung:6.10 bladder:- kidney:5.73 pituitary:5.57 thyroid/parathyroid:5.68 adrenal gland:5.60 pancreas:6.04 breast:5.33 salivary:5.52
CAGE uterus:1.02 placenta:0.16 prostate:0.27 ovary:2.94 testis:3.12 heart:0 muscle:0.25 esophagus:0 stomach:- intestine:0.07 colon:0     liver/hepato:0    lung:3.24 bladder:0.69 kidney:0.95 pituitary:0.32 thyroid/parathyroid:0.23 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.80 ovary:3.39 testis:3.01 heart:0 muscle:0.09 esophagus:- stomach:- intestine:- colon:0.27     liver/hepato:0.02        lung:4.12    bladder:- kidney:0.95 pituitary:- thyroid/parathyroid:0.84 adrenal gland:0.03 pancreas:- breast:0.13 salivary:-

Gene Information

IDs

Refseq ID NM_001454
Gene ID 2302
Unigene ID Hs.651204
Probe set ID 205906_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000129654
GTEx ID ENSG00000129654

Orthologous Gene

Mouse[1]  NM_008240
Rat[1]  NM_008240

Chromosomal Region

17q25.1  [74,132,425  -  74,137,380]

Gene Family (Interpro ID)

IPR001766  Transcription factor, fork head
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

9073514
9096351
9530170
11060460
12477932
15489334
16518568
17008636
17474147
18160851
20539013
21988832
22488567
22945654
23479743
23822649

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0032862  activation of Rho GTPase activity
GO:0007420  brain development
GO:0002508  central tolerance induction
GO:0042384  cilium assembly
GO:0030855  epithelial cell differentiation
GO:0060429  epithelium development
GO:0035089  establishment of apical/basal cell polarity
GO:0001947  heart looping
GO:0006959  humoral immune response
GO:0060972  left/right pattern formation
GO:0050900  leukocyte migration
GO:0030324  lung development
GO:0060428  lung epithelium development
GO:0050869  negative regulation of B cell activation
GO:0002635  negative regulation of germinal center formation
GO:0002924  negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0045409  negative regulation of interleukin-6 biosynthetic process
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0033085  negative regulation of T cell differentiation in the thymus
GO:0042130  negative regulation of T cell proliferation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0007389  pattern specification process
GO:0002897  positive regulation of central B cell tolerance induction
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0007283  spermatogenesis

Cellular Component

GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0008301  DNA bending activity
GO:0003677  DNA binding
GO:0003690  double-stranded DNA binding
GO:0019904  protein domain specific binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding