lysine (K)-specific demethylase 1A

Synonym

LSD1, BRAF35-HDAC complex protein BHC110, BHC110, KIAA0601, amine oxidase (flavin containing) domain 2, Lysine-specific histone demethylase 1, AOF2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:7.29

cerebellum:7.52

brain stem:7.34

corpus callosum/glia:7.02

pineal gland:-

peripheral nerve:7.13

spine:7

retina:-

eye:-

artery/aorta:7.11

vein:7.03

lymphnode:7.07

peripheral blood:-

spleen:6.87

thymus:7.92

bone marrow:7.19

adipose:7.23

bone:-

skin:7.39

CAGE

cerebrum:3.78

cerebellum:-

brain stem:3.52

corpus callosum/glia:3.53

pineal gland:3.67

peripheral nerve:-

spine:3.18

retina:-

eye:-

artery/aorta:3.56

vein:3.79

lymphnode:3.40

peripheral blood:-

spleen:3.42

thymus:4.48

bone marrow:-

adipose:3.56

bone:-

skin:-

RNA-seq

cerebrum:1.78

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.52

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.28

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:7.65

placenta:7.22

prostate:7.63

ovary:7.95

testis:9.18

heart:7.19

muscle:7.72

esophagus:7.42

stomach:7.16

intestine:7.43

colon:7.46

liver/hepato:6.77

lung:7.18

bladder:-

kidney:7.19

pituitary:7.80

thyroid/parathyroid:7.32

adrenal gland:7.32

pancreas:7.27

breast:7.48

salivary:7.31

CAGE

uterus:4.06

placenta:3.46

prostate:3.81

ovary:3.91

testis:5.07

heart:3.64

muscle:3.92

esophagus:3.64

stomach:-

intestine:3.49

colon:3.79

liver/hepato:3.34

lung:3.36

bladder:3.72

kidney:3.46

pituitary:4.18

thyroid/parathyroid:3.77

adrenal gland:-

pancreas:3.61

breast:3.22

salivary:3.74

RNA-seq

uterus:-

placenta:-

prostate:2.92

ovary:3.07

testis:3.95

heart:1.71

muscle:2.54

esophagus:-

stomach:-

intestine:-

colon:1.38

liver/hepato:0.89

lung:1.35

bladder:-

kidney:2.42

pituitary:-

thyroid/parathyroid:3.19

adrenal gland:2.38

pancreas:-

breast:2.10

salivary:-

IDs

Refseq ID	NM_001009999
Gene ID	23028
Unigene ID	-
Probe set ID	212348_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000004487
GTEx ID	ENSG00000004487

Orthologous Gene

Mouse[2]	NM_133872
Rat[1]	NM_001130098

Chromosomal Region

1p36.12 [23,345,941 - 23,410,182]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0030851	granulocyte differentiation
GO:0034720	histone H3-K4 demethylation
GO:0033169	histone H3-K9 demethylation
GO:0001701	in utero embryonic development
GO:0055001	muscle cell development
GO:0043392	negative regulation of DNA binding
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0051572	negative regulation of histone H3-K4 methylation
GO:0051573	negative regulation of histone H3-K9 methylation
GO:0032091	negative regulation of protein binding
GO:0043433	negative regulation of transcription factor activity
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0021983	pituitary gland development
GO:0045648	positive regulation of erythrocyte differentiation
GO:0046886	positive regulation of hormone biosynthetic process
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0051091	positive regulation of transcription factor activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0006482	protein amino acid demethylation
GO:0010725	regulation of primitive erythrocyte differentiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-dependent

Cellular Component

GO:0000790	nuclear chromatin
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0005667	transcription factor complex

Molecular Function

GO:0050681	androgen receptor binding
GO:0003682	chromatin binding
GO:0032451	demethylase activity
GO:0044212	DNA regulatory region binding
GO:0019899	enzyme binding
GO:0050660	FAD binding
GO:0032452	histone demethylase activity
GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)
GO:0032453	histone demethylase activity (H3-K4 specific)
GO:0032454	histone demethylase activity (H3-K9 specific)
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0043426	MRF binding
GO:0016491	oxidoreductase activity
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0003700	transcription factor activity
GO:0008134	transcription factor binding

lysine (K)-specific demethylase 1A

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function