forkhead box E1 (thyroid transcription factor 2)

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Synonym

FOXE2, TTF2, TTF-2, Thyroid transcription factor 2, forkhead box E1 (thyroid transcription factor 2), TITF2, FOXE1, FKHL15, HFKH4, HFKL5, Forkhead-related protein FKHL15, Forkhead box protein E1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:10.10 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:28.80
GeneChip cerebrum:3.05 cerebellum:3.26 brain stem:3.02 corpus callosum/glia:3.18 pineal gland:- peripheral nerve:3.10 spine:3.10 retina:- eye:- artery/aorta:3.09 vein:3.10 lymphnode:3.92 peripheral blood:- spleen:3 thymus:3.01 bone marrow:3.14 adipose:3.15 bone:- skin:3.18
CAGE cerebrum:0 cerebellum:- brain stem:0 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0.79 vein:1.29 lymphnode:1.94 peripheral blood:- spleen:0 thymus:0.91 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.03 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.01 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:4.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:4.90    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:2.97 placenta:3.04 prostate:2.93 ovary:2.89 testis:3.10 heart:3.06 muscle:3.11 esophagus:4.13 stomach:3.05 intestine:3.03 colon:2.99 liver/hepato:3.17 lung:3.05 bladder:- kidney:3.03 pituitary:3.11 thyroid/parathyroid:8.03 adrenal gland:3.01 pancreas:3.12 breast:3.09 salivary:3.05
CAGE uterus:0.54 placenta:0 prostate:0 ovary:0 testis:0.19 heart:0 muscle:0 esophagus:1.68 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0.27 bladder:0.09 kidney:0.08 pituitary:0 thyroid/parathyroid:5.56 adrenal gland:- pancreas:0 breast:0 salivary:0.62
RNA-seq uterus:- placenta:- prostate:0.03 ovary:0.05 testis:0.19 heart:0 muscle:0.06 esophagus:- stomach:- intestine:- colon:0.03     liver/hepato:0        lung:0.14    bladder:- kidney:0.02 pituitary:- thyroid/parathyroid:5.68 adrenal gland:0 pancreas:- breast:0.07 salivary:-

Gene Information

IDs

Refseq ID NM_004473
Gene ID 2304
Unigene ID Hs.159234
Probe set ID 206912_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000178919
GTEx ID ENSG00000178919

Orthologous Gene

Mouse[1]  NM_183298
Rat [0]  

Chromosomal Region

9q22.33  [100,615,536  -  100,618,986]

Gene Family (Interpro ID)

IPR001766  Transcription factor, fork head
IPR011991  Winged helix repressor DNA-binding

Link to Pubmed  (Pubmed ID)

9052737
9169137
9214635
9697705
10403172
10748198
11580993
11762722
12165566
14611701
14654228
15140221
15320969
15367491
15494458
16327884
16481406
16584930
16882747
17318017
17717707
18978678
19192046
19198613
19730683
19779022
19845668
19930442
20094846
20157192
20200978
20350937
20453517
20544801
20572854
20583170
20634891
20672350
21177256
21311165
21367965
21462296
21730105
21896990
21981779
22177572
22493691
22521644
22736773
22753311
22882326
23251661
23327367
23408906
23512105
23715628
23894154
24105688
24127282
24563486

Gene Ontology  (GO ID)

Biological Process

GO:0009653  anatomical structure morphogenesis
GO:0048846  axon extension involved in axon guidance
GO:0016477  cell migration
GO:0048562  embryonic organ morphogenesis
GO:0048484  enteric nervous system development
GO:0031069  hair follicle morphogenesis
GO:0060022  hard palate development
GO:0048937  lateral line nerve glial cell development
GO:0002089  lens morphogenesis in camera-type eye
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0007389  pattern specification process
GO:0007422  peripheral nervous system development
GO:0060465  pharynx development
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0051090  regulation of transcription factor activity
GO:0060023  soft palate development
GO:0048485  sympathetic nervous system development
GO:0048538  thymus development
GO:0030878  thyroid gland development
GO:0006590  thyroid hormone generation

Cellular Component

GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0008301  DNA bending activity
GO:0003677  DNA binding
GO:0003690  double-stranded DNA binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding