zinc fingers and homeoboxes 3

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Synonym

zinc fingers and homeoboxes 3, triple homeobox 1, KIAA0395, Zinc finger and homeodomain protein 3, Triple homeobox protein 1, ZHX3, TIX1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:51 cerebellum:88.20 brain stem:- corpus callosum/glia:87.50 pineal gland:- peripheral nerve:61.30 spine:224.60 retina:118.60 eye:76.40 artery/aorta:- vein:- lymphnode:30.30 peripheral blood:- spleen:- thymus:38.70 bone marrow:39.40 adipose:80.70 bone:38.40 skin:62.40
GeneChip cerebrum:6.36 cerebellum:6.60 brain stem:6.20 corpus callosum/glia:6.74 pineal gland:- peripheral nerve:5.34 spine:6.68 retina:- eye:- artery/aorta:6.16 vein:5.89 lymphnode:4.94 peripheral blood:- spleen:4.60 thymus:5.05 bone marrow:5.02 adipose:5.51 bone:- skin:5.63
CAGE cerebrum:3.94 cerebellum:- brain stem:3.62 corpus callosum/glia:3.95 pineal gland:3.81 peripheral nerve:- spine:4.13 retina:- eye:- artery/aorta:4.07 vein:3.19 lymphnode:2.70 peripheral blood:- spleen:2.67 thymus:2.51 bone marrow:- adipose:3.50 bone:- skin:-
RNA-seq cerebrum:3.09 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.30 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.61 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:7.30 prostate:33.80 ovary:74.50 testis:545.10 heart:38.30 muscle:40.20 esophagus:- stomach:21.20 intestine:32.40 colon:67.80     liver/hepato:31.70        lung:53.80    bladder:- kidney:187.10 pituitary:116 thyroid/parathyroid:- adrenal gland:50.80 pancreas:53.30 breast:27.90 salivary:-
GeneChip uterus:5.33 placenta:5.28 prostate:5.26 ovary:5.71 testis:5.28 heart:5.39 muscle:5.86 esophagus:5.44 stomach:5.53 intestine:5.49 colon:5.28 liver/hepato:5.93 lung:5.57 bladder:- kidney:6.75 pituitary:5.46 thyroid/parathyroid:6.31 adrenal gland:6.28 pancreas:5.46 breast:5.91 salivary:4.91
CAGE uterus:3.51 placenta:2.36 prostate:3.18 ovary:3.08 testis:3.98 heart:3.60 muscle:3.17 esophagus:3.44 stomach:- intestine:3.26 colon:3.67     liver/hepato:3.47    lung:3.29 bladder:3.58 kidney:4.13 pituitary:3.30 thyroid/parathyroid:3.20 adrenal gland:- pancreas:3.10 breast:4.03 salivary:2.72
RNA-seq uterus:- placenta:- prostate:2.90 ovary:2.11 testis:3.00 heart:2.25 muscle:2.46 esophagus:- stomach:- intestine:- colon:2.49     liver/hepato:2.43        lung:1.54    bladder:- kidney:3.55 pituitary:- thyroid/parathyroid:3.70 adrenal gland:2.32 pancreas:- breast:2.37 salivary:-

Gene Information

IDs

Refseq ID NM_015035
Gene ID 23051
Unigene ID Hs.380133
Probe set ID 217367_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000174306
GTEx ID ENSG00000174306

Orthologous Gene

Mouse[2]  NM_177263
Rat[1]  NM_001047097

Chromosomal Region

20q12  [39,807,088  -  39,946,324]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related
IPR015880  Zinc finger, C2H2-like

Link to Pubmed  (Pubmed ID)

8889548
9455477
11780052
11827452
12168954
12477932
12659632
14659886
14702039
15302935
16713569
16751776
17056598
18029348
19505873
21174497

Gene Ontology  (GO ID)

Biological Process

GO:0030154  cell differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0045669  positive regulation of osteoblast differentiation
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005737  cytoplasm
GO:0005730  nucleolus
GO:0005634  nucleus

Molecular Function

GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0043565  sequence-specific DNA binding
GO:0003714  transcription corepressor activity
GO:0003700  transcription factor activity