nuclear receptor coactivator 6

 jump to detail

Synonym

Thyroid hormone receptor-binding protein, AIB3, HOXA7, ANTP, ASC2, HOX1.1, ASC-2, Nuclear receptor-activating protein, 250 kDa, RAP250, KIAA0181, NCOA6, Cancer-amplified transcriptional coactivator ASC-2, Nuclear receptor coactivator 6, nuclear receptor coactivator 6, PRIP, Amplified in breast cancer protein 3, NRC, Nuclear receptor coactivator RAP250, PPAR-interacting protein, NRC RAP250, Activating signal cointegrator 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:78.20 cerebellum:37.80 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:- spine:112.30 retina:- eye:47 artery/aorta:179.90 vein:- lymphnode:91 peripheral blood:- spleen:37.80 thymus:38.70 bone marrow:98.40 adipose:40.30 bone:12.80 skin:168
GeneChip cerebrum:7.30 cerebellum:7.99 brain stem:7.09 corpus callosum/glia:7.85 pineal gland:- peripheral nerve:7.33 spine:7.42 retina:- eye:- artery/aorta:7.26 vein:7.42 lymphnode:7.24 peripheral blood:- spleen:7.49 thymus:8.17 bone marrow:7.35 adipose:7.39 bone:- skin:7.85
CAGE cerebrum:3.20 cerebellum:- brain stem:3.30 corpus callosum/glia:3.81 pineal gland:3.37 peripheral nerve:- spine:3.44 retina:- eye:- artery/aorta:3.15 vein:2.95 lymphnode:2.98 peripheral blood:- spleen:2.78 thymus:3.10 bone marrow:- adipose:3.01 bone:- skin:-
RNA-seq cerebrum:2.24 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.07 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.76 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:80.10 prostate:22.50 ovary:37.30 testis:30.30 heart:51.10 muscle:20.10 esophagus:- stomach:42.50 intestine:- colon:110.20     liver/hepato:10.60        lung:63.50    bladder:- kidney:31.20 pituitary:232 thyroid/parathyroid:- adrenal gland:- pancreas:62.20 breast:167.30 salivary:-
GeneChip uterus:7.83 placenta:8.08 prostate:7.93 ovary:7.83 testis:8.40 heart:7.15 muscle:7.25 esophagus:7.57 stomach:7.41 intestine:7.18 colon:7.32 liver/hepato:7.04 lung:7.33 bladder:- kidney:7.36 pituitary:7.54 thyroid/parathyroid:7.64 adrenal gland:7.18 pancreas:6.93 breast:7.69 salivary:7.60
CAGE uterus:3.01 placenta:3.28 prostate:2.96 ovary:2.87 testis:3.14 heart:2.94 muscle:2.84 esophagus:2.87 stomach:- intestine:3.48 colon:3.47     liver/hepato:2.46    lung:2.96 bladder:2.87 kidney:3.06 pituitary:3.01 thyroid/parathyroid:2.92 adrenal gland:- pancreas:3.16 breast:3.27 salivary:2.93
RNA-seq uterus:- placenta:- prostate:3.22 ovary:3.36 testis:3.32 heart:2.38 muscle:2.52 esophagus:- stomach:- intestine:- colon:2.64     liver/hepato:1.81        lung:2.74    bladder:- kidney:2.77 pituitary:- thyroid/parathyroid:2.74 adrenal gland:2.34 pancreas:- breast:2.41 salivary:-

Gene Information

IDs

Refseq ID NM_014071
Gene ID 23054
Unigene ID Hs.368971
Probe set ID 208979_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000198646
GTEx ID ENSG00000198646

Orthologous Gene

Mouse[1]  NM_001242558, NM_019825
Rat[1]  NM_001242558, NM_019825

Chromosomal Region

20q11.22  [33,302,578  -  33,413,452]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7536696
8263591
8724849
8758910
10497212
10567404
10681503
10788465
10823961
10847592
10866662
11158331
11302752
11443112
11517327
11704680
11773444
11780052
11912212
12039952
12168954
12189208
12215545
12477932
12482968
12519782
12724417
12754253
14578865
14638867
14645241
14734562
14960326
15231748
15302935
15604093
15764585
16794079
17021013
17178841
17500065
17761849
17925232
18029348
18031289
18263591
18462265
18552123
18660489
18854154
19047629
19329434
19556342
20379614
20721975
21292004
21330447
21552418
22939629
23314748

Gene Ontology  (GO ID)

Biological Process

GO:0007420  brain development
GO:0044255  cellular lipid metabolic process
GO:0006310  DNA recombination
GO:0006281  DNA repair
GO:0006260  DNA replication
GO:0030520  estrogen receptor signaling pathway
GO:0042921  glucocorticoid receptor signaling pathway
GO:0007507  heart development
GO:0060716  labyrinthine layer blood vessel development
GO:0030099  myeloid cell differentiation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006974  response to DNA damage stimulus
GO:0009725  response to hormone stimulus
GO:0006352  transcription initiation
GO:0006367  transcription initiation from RNA polymerase II promoter

Cellular Component

GO:0035097  histone methyltransferase complex
GO:0043231  intracellular membrane-bounded organelle
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0003682  chromatin binding
GO:0019899  enzyme binding
GO:0030331  estrogen receptor binding
GO:0030374  ligand-dependent nuclear receptor transcription coactivator activity
GO:0005515  protein binding
GO:0046965  retinoid X receptor binding
GO:0046966  thyroid hormone receptor binding
GO:0003713  transcription coactivator activity